期刊
CHEMISTRY & BIODIVERSITY
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202300229
关键词
Magellan Seamount-derived fungus; Penicillium rubens; sesquiterpenoid; polyketide; antimicrobial activity
Rubenpolyketone A (1), a new polyketide with a unique carbon skeleton, and a new linear sesquiterpenoid, chermesiterpenoid D (2), were isolated from the fungus Penicillium rubens AS-130. Seven known secondary metabolites (3-9) were also identified. The structures of the compounds were determined through NMR and mass spectroscopic analysis, and the absolute configurations of the new compounds were elucidated using quantum mechanical (QM)-NMR and time-dependent density functional (TDDFT) ECD calculation approaches. Chermesiterpenoids B (3) and C (4) exhibited potent inhibitory activities against Vibrio anguillarum, with MIC values of 0.5 and 1 μg/mL, respectively. Chermesin F (6) showed activity against Escherichia coli, with a MIC value of 1 μg/mL.
Rubenpolyketone A (1), a polyketide featuring a new carbon skeleton having cyclohexenone condensed with a methyl octenone chain and a new linear sesquiterpenoid, chermesiterpenoid D (2), together with seven known secondary metabolites (3-9) were isolated and identified from the Magellan Seamount-derived fungus Penicillium rubens AS-130. Their structures were determined based on detailed analysis of NMR and mass spectroscopic data and the absolute configurations of these two new compounds were elucidated by the combination of quantum mechanical (QM)-NMR and time-dependent density functional (TDDFT) ECD calculation approaches. Chermesiterpenoids B (3) and C (4) showed potent inhibitory activities against the aquatic pathogen Vibrio anguillarum with MIC values of 0.5 and 1 mu g/mL, respectively, while chermesin F (6) exhibited activity against Escherichia coli with MIC value of 1 mu g/mL.
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