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ACCOUNTS OF CHEMICAL RESEARCH (2016)
A Simple and Versatile Amide Directing Group for C-H Functionalizations
Ru-Yi Zhu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
Tim Cernak et al.
CHEMICAL SOCIETY REVIEWS (2016)
Constrained Cyclopeptides: Biaryl Formation through Pd-Catalyzed C-H Activation in Peptides-Structural Control of the Cyclization vs. Cyclodimerization Outcome
Lorena Mendive-Tapia et al.
CHEMISTRY-A EUROPEAN JOURNAL (2016)
An Additive Definition of Molecular Complexity
Thomas Boettcher
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2016)
Recent Advances in C-H Functionalization
Huw M. L. Davies et al.
JOURNAL OF ORGANIC CHEMISTRY (2016)
Palladium-catalysed transannular C-H functionalization of alicyclic amines
Joseph J. Topczewski et al.
NATURE (2016)
C8-Selective Acylation of Quinoline N-Oxides with α-Oxocarboxylic Acids via Palladium-Catalyzed Regioselective C-H Bond Activation
Xiaopei Chen et al.
ORGANIC LETTERS (2016)
One-Pot Approach to 8-Acylated 2-Quinolinones via Palladium-Catalyzed Regioselective Acylation of Quinoline N-Oxides
Xiaopei Chen et al.
ORGANIC LETTERS (2016)
A general catalytic β-C-H carbonylation of aliphatic amines to β-lactams
Darren Willcox et al.
SCIENCE (2016)
β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp3)-H bonds using a palladium catalyst
Jing Peng et al.
CHEMICAL SCIENCE (2016)
Functionalized Polymer-Supported Pyridine Ligands for Palladium-Catalyzed C(sp3)-H Arylation
Li-Chen Lee et al.
ACS CATALYSIS (2016)
Regioselectivity in palladium-catalysed direct arylation of 5-membered ring heteroaromatics
Charles Beromeo Bheeter et al.
CATALYSIS SCIENCE & TECHNOLOGY (2016)
Pd(II)-catalyzed beta-C-H arylation of O-methyl ketoximes with iodoarenes
Yucheng Mu et al.
ORGANIC CHEMISTRY FRONTIERS (2016)
Undirected, Homogeneous C-H Bond Functionalization: Challenges and Opportunities
John F. Hartwig et al.
ACS CENTRAL SCIENCE (2016)
Enabling Technologies for the Future of Chemical Synthesis
Daniel E. Fitzpatrick et al.
ACS CENTRAL SCIENCE (2016)
The Chemical Space Project
Jean-Louis Reymond
ACCOUNTS OF CHEMICAL RESEARCH (2015)
Tandem Z-Selective Cross-Metathesis/Dihydroxylation: Synthesis of anti-1,2-Diols
Peter K. Dornan et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Catalytic Silylation of Unactivated C-H Bonds
Chen Cheng et al.
CHEMICAL REVIEWS (2015)
Nickel Catalysts/N,N′-Bidentate Directing Groups: An Excellent Partnership in Directed C-H Activation Reactions
Luis C. Misal Castro et al.
CHEMISTRY LETTERS (2015)
Late-Stage Peptide Diversification by Bioorthogonal Catalytic CH Arylation at 23°C in H2O
Yingjun Zhu et al.
CHEMISTRY-A EUROPEAN JOURNAL (2015)
Iridium(III)-Catalyzed Direct Arylation of C-H Bonds with Diaryliodonium Salts
Pan Gao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
An analysis of the attrition of drug candidates from four major pharmaceutical companies
Michael J. Waring et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Current complexity: a tool for assessing the complexity of organic molecules
Jun Li et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2015)
Introduction of Hindered Electrophiles via C-H Functionalization in a Palladium-Catalyzed Multicomponent Domino Reaction
Zafar Qureshi et al.
SYNTHESIS-STUTTGART (2015)
Late-stage C-H functionalization of complex alkaloids and drug molecules via intermolecular rhodium-carbenoid insertion
Jing He et al.
NATURE COMMUNICATIONS (2015)
New peptide architectures through C-H activation stapling between tryptophan-phenylalanine/tyrosine residues
Lorena Mendive-Tapia et al.
NATURE COMMUNICATIONS (2015)
Weakly Coordinating Directing Groups for Ruthenium(II)-Catalyzed C-H Activation
Suman De Sarkar et al.
ADVANCED SYNTHESIS & CATALYSIS (2014)
C-H Functionalization in the Synthesis of Amino Acids and Peptides
Anais F. M. Noisier et al.
CHEMICAL REVIEWS (2014)
Late-Stage Diversification of Peptides by Metal-Free C-H Arylation
Yingjun Zhu et al.
CHEMISTRY-A EUROPEAN JOURNAL (2014)
Modeling a Crowdsourced Definition of Molecular Complexity
Robert P. Sheridan et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2014)
Targeting the Androgen Receptor with Steroid Conjugates
Paul M. Levine et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Rings in Drugs
Richard D. Taylor et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Beyond Classical Reactivity Patterns: Hydroformylation of Vinyl and Allyl Arenes to Valuable β- and γ-Aldehyde Intermediates Using Supramolecular Catalysis
Pawel Dydio et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Role of Sterically Demanding Chiral Dirhodium Catalysts in Site-Selective C-H Functionalization of Activated Primary C-H Bonds
Changming Qin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Site-Selective C(sp3)-H Functionalization of Di-, Tr-, and Tetrapeptides at the N-Terminus
Wei Gong et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Regioselective Introduction of Heteroatoms at the C-8 Position of Quinoline N-Oxides: Remote C-H Activation Using N-Oxide as a Stepping Stone
Heejun Hwang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Cobalt-Catalyzed Hydroarylative Cyclization of 1,6-Enynes with Aromatic Ketones and Esters via C-H Activation
Rajagopal Santhoshkumar et al.
ORGANIC LETTERS (2014)
Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory
K. C. Nicolaou
PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2014)
Threefold Cross-Linked Polystyrene-Triphenylphosphane Hybrids: Mono-P-Ligating Behavior and Catalytic Applications for Aryl Chloride Cross-Coupling and C(sp3)-H Borylation
Tomohiro Iwai et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
C-H Functionalization Logic Enables Synthesis of (+)-Hongoquercin A and Related Compounds
Brandon R. Rosen et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Profound Methyl Effects in Drug Discovery and a Call for New C-H Methylation Reactions
Heike Schoenherr et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
A Cationic High-Valent Cp*CoIII Complex for the Catalytic Generation of Nucleophilic Organometallic Species: Directed C-H Bond Activation
Tatsuhiko Yoshino et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
On Water, Phosphine-Free Palladium-Catalyzed Room Temperature C-H Arylation of Indoles
Saidul Islam et al.
CHEMISTRY-A EUROPEAN JOURNAL (2013)
Meta-Selective C-H Functionalization Using a Nitrile-Based Directing Group and Cleavable Si-Tether
Sunggi Lee et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
meta-Selective C-H Bond Alkylation with Secondary Alkyl Halides
Nora Hofmann et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Simultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate
Jing Li et al.
NATURE CHEMISTRY (2013)
A robustness screen for the rapid assessment of chemical reactions
Karl D. Collins et al.
NATURE CHEMISTRY (2013)
Silica-Immobilized Chiral Dirhodium(II) Catalyst for Enantioselective Carbenoid Reactions
Kathryn M. Chepiga et al.
ORGANIC LETTERS (2013)
Weak Coordination as a Powerful Means for Developing Broadly Useful C-H Functionalization Reactions
Keary M. Engle et al.
ACCOUNTS OF CHEMICAL RESEARCH (2012)
C-H Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals
Junichiro Yamaguchi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Targeting the Estrogen Receptor using Steroid-Therapeutic Drug Conjugates (Hybrids)
Kinh-Luan Dao et al.
BIOCONJUGATE CHEMISTRY (2012)
Peptidic macrocyclization via palladium-catalyzed chemoselective indole C-2 arylation
Huijun Dong et al.
CHEMICAL COMMUNICATIONS (2012)
Dehydrative C-H Alkylation and Alkenylation of Phenols with Alcohols: Expedient Synthesis for Substituted Phenols and Benzofurans
Dong-Hwan Lee et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Catalytic Functionalization of Unactivated sp3 C-H Bonds via exo-Directing Groups: Synthesis of Chemically Differentiated 1,2-Diols
Zhi Ren et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Activation of remote meta-C-H bonds assisted by an end-on template
Dasheng Leow et al.
NATURE (2012)
Metal-Free N-H Insertions of Donor/Acceptor Carbenes
Stephanie R. Hansen et al.
ORGANIC LETTERS (2012)
Ruthenium-Catalyzed C-H Bond Arylations of Arenes Bearing Removable Directing Groups via Six-Membered Ruthenacycles
Lutz Ackermann et al.
ORGANIC LETTERS (2012)
Oxidizing Directing Groups Enable Efficient and Innovative C-H Activation Reactions
Frederic W. Patureau et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Palladium-Catalyzed Borylation of Sterically Demanding Aryl Halides with a Silica-Supported Compact Phosphane Ligand
Soichiro Kawamorita et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
One-Step Catalytic Asymmetric Synthesis of Configurationally Stable Troger Bases
Ankit Sharma et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
1,2,3-Triazoles in Peptidomimetic Chemistry
Daniel Sejer Pedersen et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2011)
Ruthenium-Catalyzed Meta Sulfonation of 2-Phenylpyridines
Ourida Saidi et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Divergent C-H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery
Hui-Xiong Dai et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Carboxylate-Assisted Ruthenium-Catalyzed Direct Alkylations of Ketimines
Lutz Ackermann et al.
ORGANIC LETTERS (2011)
Selective Catalytic C-H Alkylation of Alkenes with Alcohols
Dong-Hwan Lee et al.
SCIENCE (2011)
Regioselective Functionalization of the Imidazole Ring via Transition Metal-Catalyzed C-N and C-C Bond Forming Reactions
Fabio Bellina et al.
ADVANCED SYNTHESIS & CATALYSIS (2010)
1,7-Disubstituted oxyindoles are potent and selective EP3 receptor antagonists
Nian Zhou et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Postsynthetic Modification of Peptides: Chemoselective C-Arylation of Tryptophan Residues
Javier Ruiz-Rodriguez et al.
CHEMISTRY-A EUROPEAN JOURNAL (2010)
Enantioselective Ring Opening of Epoxides by Fluoride Anion Promoted by a Cooperative Dual-Catalyst System
Julia A. Kalow et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
[Ir(COD)Cl]2 as a Catalyst Precursor for the Intramolecular Hydroamination of Unactivated Alkenes with Primary Amines and Secondary Alkyl- or Arylamines: A Combined Catalytic, Mechanistic, and Computational Investigation
Kevin D. Hesp et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Pd(II)-Catalyzed Carbonylation of C(sp3)-H Bonds: A New Entry to 1,4-Dicarbonyl Compounds
Eun Jeong Yoo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Intermolecular Dehydrative Coupling Reaction of Aryl Ketones with Cyclic Alkenes Catalyzed by a Well-Defined Cationic Ruthenium-Hydride Complex: A Novel Ketone Olefination Method via Vinyl C-H Bond Activation
Chae S. Yi et al.
ORGANOMETALLICS (2010)
Ruthenium-Catalyzed Regioselective Direct Alkylation of Arenes with Unactivated Alkyl Halides through C-H Bond Cleavage
Lutz Ackermann et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Fluorinated isatin derivatives. Part 1: Synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl) sulfonyl]isatins as potent caspase-3 and-7 inhibitors
Anil Kumar Podichetty et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
Frank Lovering et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Regioselective Ruthenium-Catalyzed Direct Benzylations of Arenes through C-H Bond Cleavages
Lutz Ackermann et al.
ORGANIC LETTERS (2009)
Regioselective Intermolecular Coupling Reaction of Arylketones and Alkenes Involving C-H Bond Activation Catalyzed by an in Situ Formed Cationic Ruthenium Hydride Complex
Chae S. Yi et al.
ORGANOMETALLICS (2009)
Total Synthesis of (+)-11,11′-Dideoxyverticillin A
Justin Kim et al.
SCIENCE (2009)
Estimation of synthetic accessibility score of drug-like molecules based on molecular complexity and fragment contributions
Peter Ertl et al.
JOURNAL OF CHEMINFORMATICS (2009)
Pd(II)-catalyzed cross-coupling of sp3 C-H bonds with sp2 and sp3 boronic acids using air as the oxidant
Dong-Hui Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Asymmetric intramolecular arylcyanation of unactivated Olefins via C-CN bond activation
Mary P. Watson et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Total Syntheses of (±)-Massadine and Massadine Chloride
Shun Su et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Room temperature and phosphine free palladium catalyzed direct C-2 arylation of indoles
Nathalie Lebrasseur et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Synthesis of 1,2-and 1,3-Dicarboxylic Acids via Pd(II)-Catalyzed Carboxylation of Aryl and Vinyl C-H Bonds
Ramesh Giri et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Palladium-catalyzed methylation and arylation of sp2 and sp3 C-H bonds in simple carboxylic acids
Ramesh Giri et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Multisubstituted olefins: Platform synthesis and applications to materials science and pharmaceutical chemistry
Kenichiro Itami et al.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN (2006)
Computational methods in developing quantitative structure-activity relationships (QSAR):: A review
AZ Dudek et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2006)
Recent advances in the Stevens rearrangement of ammonium ylides. Application to the synthesis of alkaloid natural products
JA Vanecko et al.
TETRAHEDRON (2006)
Green solvents for sustainable organic synthesis: state of the art
RA Sheldon
GREEN CHEMISTRY (2005)
Atroposelective synthesis of axially chiral biaryl compounds
G Bringmann et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)