☆ 4.8 Review

Late-Stage C-H Functionalization of Azines

CHEMICAL REVIEWS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Chemistry, Multidisciplinary

Photocatalytic Late-Stage C-H Functionalization

Peter Bellotti et al.

Summary: The emergence of modern photocatalysis has revolutionized late-stage C-H functionalization, offering unprecedented regio- and chemoselectivities. This Review focuses on the strategies of small-molecule drugs, agrochemicals, and natural products, highlighting the main mechanistic scenarios and comparing established ionic chemistry and photocatalyzed radical-based manifolds. The authors aim to provide a comprehensive overview of the current state-of-the-art and address the challenges and future directions in this field.

CHEMICAL REVIEWS (2023)

添加到收藏夹

Correction Chemistry, Organic

Metal-, Photocatalyst-, and Light-Free Minisci C-H Alkylation of N-Heteroarenes with Oxalates (vol 84, pg 7532, 2019)

Jianyang Dong et al.

JOURNAL OF ORGANIC CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Visible-Light-Induced C4-Selective Functionalization of Pyridinium Salts with Cyclopropanols

Mari Vellakkaran et al.

Summary: This study presents a general strategy for site-selective C-H functionalization of heteroarenes, specifically achieving high site selectivity at the C4 position of pyridines through visible-light-induced beta-carbonyl alkylation. The method enables the synthesis of valuable beta-pyridylated (aryl)ketones, aldehydes, and esters with broad functional-group tolerance, serving as an effective tool for late-stage functionalization of complex and medicinally relevant molecules.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Metallaphotoredox: The Merger of Photoredox and Transition Metal Catalysis

Amy Y. Chan et al.

Summary: The merger of photoredox catalysis with transition metal catalysis, known as metallaphotoredox catalysis, has become an important part of synthetic methodology. It combines the bond formation capability of transition metal catalysis with the utility of photoinduced electron and energy transfer processes. Photocatalytic substrate activation allows the involvement of simple starting materials in metal-mediated bond-forming processes, while electron or energy transfer with organometallic intermediates provides a complementary activation mode to traditional catalytic platforms.

CHEMICAL REVIEWS (2022)

添加到收藏夹

Article Chemistry, Organic

Catalytic Hydrogen Isotope Exchange Reactions in Late-Stage Functionalization

Qi-Kai Kang et al.

Summary: Introducing deuterium and tritium into molecules is crucial for drug discovery. Recent advancements in catalytic HIE reactions have provided efficient methods for late-stage labeling of bioactive complex molecules and pharmaceuticals, avoiding multistep syntheses.

SYNLETT (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

A Perspective on Late-Stage Aromatic C-H Bond Functionalization

Li Zhang et al.

Summary: Aromatic C-H late-stage functionalization poses challenges in terms of reactivity, selectivity, and substrate scope, but also shows potential for development. It is necessary to address current challenges and explore new strategies and directions for growth.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

C2-Selective, Functional-Group-Divergent Amination of Pyrimidines by Enthalpy-Controlled Nucleophilic Functionalization

Won Seok Ham et al.

Summary: This study describes a synthetic platform for site-selective C-H functionalization, which can be transformed into various amine products in situ. The method is compatible with a broad range of pyrimidines with sensitive functional groups and can access complex aminopyrimidines with high selectivity.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Alkyl/Glycosyl Sulfoxides as Radical Precursors and Their Use in the Synthesis of Pyridine Derivatives

Demeng Xie et al.

Summary: This research presents the use of alkyl sulfoxides as precursors to radicals in the synthesis of pyridine derivatives. It demonstrates that alkyl sulfoxides, N-methoxy pyridinium salts, and fluoride anions form electron donor-acceptor complexes in solution, which can undergo a radical chain process upon visible light irradiation to produce various pyridine derivatives efficiently. The broad scope of this reaction extends to different sulfoxides and N-methoxy pyridiniums. The synthetic versatility of sulfoxides as radical precursors adds to their significance as a useful tool in chemistry.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Borane-Catalyzed C3-Alkylation of Pyridines with Imines,Aldehydes, or Ketones as Electrophiles

Zhong Liu et al.

Summary: This study reports a borane-catalyzed tandem reaction method that achieves exclusively C3-selective alkylation of pyridines, providing a practical tool for late-stage functionalization of structurally complex pharmaceuticals bearing a pyridine moiety.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

添加到收藏夹

Correction Chemistry, Organic

Metal-, Photocatalyst-, and Light-Free Minisci C-H Alkylation of N-Heteroarenes with Oxalates (vol 84, pg 7532, 2019)

Jianyang Dong et al.

JOURNAL OF ORGANIC CHEMISTRY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Radical and ionic meta-C-H functionalization of pyridines, quinolines, and isoquinolines

Hui Cao et al.

Summary: This article introduces a highly selective method for functionalization of pyridines at the meta position, achieving trifluoromethylation, perfluoroalkylation, chlorination, bromination, iodination, nitration, sulfanylation, and selenylation through a dearomatization-rearomatization process. The method can be applied for late-stage functionalization of drugs.

SCIENCE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Halogenation of the 3-position of pyridines through Zincke imine intermediates

Benjamin T. Boyle et al.

Summary: This study reports a new method for pyridine halogenation reactions, which involves a reaction sequence of pyridyl ring opening, halogenation, and ring closing to achieve highly regioselective halogenation reactions on pyridine precursors. Experimental and computational mechanistic studies show that the nature of the halogen electrophile can modify the selectivity-determining step.

SCIENCE (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

C3-Selective Trifluoromethylthiolation and Difluoromethylthiolation of Pyridines and Pyridine Drugs via Dihydropyridine Intermediates

Xin-Yue Zhou et al.

Summary: In this study, a method for functionalization of pyridines was reported, which exhibits high selectivity towards trifluoromethylthio and difluoromethylthio groups. The method can be used for late-stage functionalization of pyridine drugs, resulting in the generation of new drug candidates.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Molecular editing of aza-arene C-H bonds by distance, geometry and chirality

Zhoulong Fan et al.

Summary: This study presents two distinct directing templates that allow for the differentiation and functionalization of remote and similar positions on bicyclic aza-arenes. This strategy enables site-selective C-H olefination, alkynylation, and allylation reactions on quinoline-containing compounds, and can be performed in a modular fashion in different orders.

NATURE (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

N-Functionalized Pyridinium Salts: A New Chapter for Site-Selective Pyridine C-H Functionalization via Radical-Based Processes under Visible Light Irradiation

Myojeong Kim et al.

Summary: This article provides a comprehensive overview of the development of N-functionalized pyridinium salts and summarizes the cornerstones of organic reactions that successfully employ these pyridinium salts under visible light conditions. Major advances in the field are systematically categorized based on the pyridines' N-substituent, N-X (X = O, N, C, and SO2CF3), and its reactivity patterns.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Enantioselective C2-H Alkylation of Pyridines with 1,3-Dienes via Ni-Al Bimetallic Catalysis

Jiang-Fei Li et al.

Summary: A chiral phosphine oxide-ligated Ni-Al bimetallic catalyst was successfully utilized for an enantioselective C2-H alkylation of pyridines, showing compatibility with a wide range of pyridine substrates and providing high yields and enantioselectivities.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

添加到收藏夹

Article Chemistry, Organic

Desulfinative Alkylation of Heteroarenes via an Electrostatic Electron

Ramkrishna Laha et al.

Summary: A method for desulfinative alkylation of pyridine and quinoline N-methoxide salts is reported, which operates under both photocatalytic and electrostatic electron donor-acceptor-mediated pathways.

ORGANIC LETTERS (2022)

添加到收藏夹

Article Chemistry, Organic

3-Position-Selective C-H Trifluoromethylation of Pyridine Rings Based on Nucleophilic Activation br

Ryuhei Muta et al.

Summary: The first example of 3-position-selective C(sp2)-H trifluoromethylation of pyridine rings was successfully achieved. This reaction can be used for perfluoroalkylation at the 3 position of pyridine rings and late-stage trifluoromethylation of bioactive molecules.

ORGANIC LETTERS (2022)

添加到收藏夹

Review Chemistry, Applied

Recent Advances in the Synthesis of C2-Functionalized Pyridines and Quinolines Using N-Oxide Chemistry

Dong Wang et al.

Summary: Recent progress has been made in the direct C-H functionalization of azines, but limitations still exist. In contrast, C2-functionalized pyridines and quinolines can be easily synthesized under appropriate activation conditions.

ADVANCED SYNTHESIS & CATALYSIS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Mechanochemical Solvent-Free Catalytic C-H Methylation

Shengjun Ni et al.

Summary: This new mechanochemical method enables highly regioselective C-H methylation of (hetero)arenes, showing excellent functional-group compatibility and shorter reaction times, and can be used for the synthesis of biologically active compounds.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Visible-Light-Induced 1,3-Aminopyridylation of [1.1.1]Propellane with N-Aminopyridinium Salts

Sanghoon Shin et al.

Summary: The formation of an electron donor-acceptor complex allowed for the direct installation of amino and pyridyl groups onto bicyclo[1.1.1]pentane (BCP) frameworks in the absence of an external photocatalyst. This method is robust and metal-free, enabling late-stage modification of structurally complex biorelevant molecules. The strategy also facilitates the incorporation of functional groups with pyridine across the BCP core, significantly expanding the range of potential applications for drug discovery.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Late-Stage Alkylation of Heterocycles Using N-(Acyloxy)phthalimides

Sushanta Kumar Parida et al.

Summary: Synthetic methods enabling late-stage modification of heterocycles are crucial in the pharmaceutical and agrochemical industry. The development of catalysts has made C-H alkylation of heterocycles more accessible and efficient, leading to significant breakthroughs in medicinal chemistry.

CHEMISTRY-AN ASIAN JOURNAL (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

A directive Ni catalyst overrides conventional site selectivity in pyridine C-H alkenylation

Tao Zhang et al.

Summary: This study reports a bifunctional N-heterocyclic carbene-ligated Ni-Al catalyst that can smoothly carry out the C3-H alkenylation of pyridines. This method provides a series of C3-alkenylated pyridines in yields ranging from 43-99% and with up to 98:2 C3 selectivity. It is effective for late-stage C3 alkenylation of diverse complex pyridine motifs in bioactive molecules, allowing various pyridine and heteroarene substrates to be used as the limiting reagent.

NATURE CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Medicinal

US FDA Approved Drugs from 2015-June 2020: A Perspective

Priyadeep Bhutani et al.

Summary: This study compiled and analyzed 245 drugs approved by the U.S. FDA from 2015 to June 2020, focusing on cancer, infectious diseases, neurological conditions, and genetic, metabolic, cardiovascular disorders. The analysis also looked at the structural, elemental, and functional group diversity among the approved drugs, as well as drug-likeness for the approved drugs.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Review Chemistry, Medicinal

The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design

Yong Ling et al.

Summary: Pyridine-based ring systems are extensively used in drug design, with many therapeutic agents derived from pyridine or dihydropyridine approved for various diseases. The prospects of more drugs containing these two heterocycles in the future look promising, as they continue to play an expanding role in medicinal chemistry and drug development.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Hydrogen Atom Transfer-Driven Enantioselective Minisci Reaction of Amides

Rupert S. J. Proctor et al.

Summary: Minisci-type reactions are powerful methods for building complexity around basic heteroarenes. The disclosed method enables coupling of linear amides and heteroarenes with control of enantioselectivity at the newly formed stereocenter and site selectivity on both the heteroarene and the amide. This is achieved using a chiral phosphoric acid catalyst in conjunction with diacetyl as a combined hydrogen atom transfer reagent and oxidant, without the need for an extraneous photocatalyst.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Azine Activation via Silylium Catalysis

Carla Obradors et al.

Summary: The study presents a direct functionalization of azines via silylium activation, with a catalyst design that allows mild conditions and remarkable functional group tolerance in a one-pot setup.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Phosphorus-mediated sp2-sp3 couplings for C-H fluoroalkylation of azines

Xuan Zhang et al.

Summary: Fluoroalkyl groups have significant effects on the physical properties of pharmaceuticals and impact various metrics related to their pharmacokinetics and pharmacodynamics. The development of new fluoroalkylation reactions has led to the direct conversion of C-H bonds into complex C-CF2X groups in drug-like molecules. A novel approach using bench-stable fluoroalkylphosphines allows for the selective conversion of C-H bonds in pyridine building blocks and pharmaceuticals without the need for preinstalled functional groups or directing groups.

NATURE (2021)

添加到收藏夹

Review Chemistry, Organic

Organophotoredox-Catalyzed Late-Stage Functionalization of Heterocycles

Sudhir Kumar Hota et al.

Summary: This review summarizes the developments in the late-stage functionalization of heterocycles over the past five years, highlighting the use of organophotocatalysts and providing insights into the research field.

ASIAN JOURNAL OF ORGANIC CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Four-Selective Pyridine Alkylation via Wittig Olefination of Dearomatized Pyridylphosphonium Ylides

Patrick J. Fricke et al.

Summary: The method presents a distinct approach to constructing 4-alkylpyridines using dearomatized pyridylphosphonium ylide intermediates. Pyridine N-activation is crucial, enabling coupling between a wide variety of substituted pyridines and aldehydes. This approach provides an alternative to metal-catalyzed sp(2)-sp(3) cross-coupling reactions and Minisci-type processes.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer

Thomas R. Puleo et al.

Summary: A new method is reported for the direct C-H etherification of N-heteroarenes under basic conditions, using potassium tert-butoxide as a catalyst and 2-halothiophenes as a reagent for halogen transfer. This protocol allows for regioselective oxidative coupling of alcohols with a variety of N-heteroarenes, such as 1,3-azoles, pyridines, diazines, and polyazines.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A radical approach for the selective C-H borylation of azines

Ji Hye Kim et al.

Summary: A new strategy for the borylation of azines has been developed, utilizing stable and inexpensive amine-borane reagents in conjunction with photocatalysis. This approach allows for selective borylation of nitrogen-containing aromatic heterocycles through the formation of highly reactive boryl radicals, providing an alternative tactic for sp(2) carbon-boron bond assembly. The strong nucleophilic character of the amine-boryl radicals enables predictable and site-selective carbon-boron bond formation in azine structures, leading to the preparation of borylated materials that are otherwise difficult to access.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A tautomeric ligand enables directed C-H hydroxylation with molecular oxygen

Zhen Li et al.

Summary: This study reports a palladium complex that efficiently catalyzes hydroxylation of aryl carbon-hydrogen bonds at positions adjacent to carboxylic acids. The catalyst overturns the conventional site selectivity dictated by heterocycles, allowing late-stage modification of pharmaceutical compounds at previously inaccessible sites. Infrared, x-ray, and computational analysis support a potential role of ligand tautomerization in the catalytic cycle of this reaction.

SCIENCE (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Late-stage C-H functionalization offers new opportunities in drug discovery

Lucas Guillemard et al.

Summary: In the past decade, the introduction of late-stage functionalization methodologies has significantly advanced the landscape of molecular synthesis. Particularly, C-H functionalization approaches have led to improvements in resource economy and new strategies for drug discovery. However, challenges and limitations in current LSF methods indicate the need for future improvements and development of new approaches.

NATURE REVIEWS CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

The emergence of the C-H functionalization strategy in medicinal chemistry and drug discovery

Ranjan Jana et al.

Summary: Due to market competition and societal demand, the speed of drug discovery is crucial for successful implementation. C-H activation technology allows for rapid construction and modification of functional molecules, expanding chemical space and offering immense potential for rapid synthesis and structural modification of drug molecules.

CHEMICAL COMMUNICATIONS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Pyridylphosphonium salts as alternatives to cyanopyridines in radical-radical coupling reactions

Jacob W. Greenwood et al.

Summary: Radical couplings of cyanopyridine radical anions offer a valuable technology for functionalizing pyridines in pharmaceuticals, agrochemicals, and materials. This study demonstrates that pyridylphosphonium salts can be useful alternatives to cyanopyridines in radical-radical coupling reactions, expanding the scope of complex pyridines. Additionally, late-stage functionalization of pharmaceuticals is highlighted as an advantage of pyridylphosphonium salts over cyanopyridines.

CHEMICAL SCIENCE (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Late-stage difluoromethylation: concepts, developments and perspective

Jeroen B. I. Sap et al.

Summary: This review discusses recent advances in difluoromethylation processes, focusing on X-CF2H bond formation and the development of various difluoromethylation reagents. Metal-based methods have shown promise in transferring CF2H to C(sp(2)) sites, while Minisci-type radical chemistry has been successfully applied to difluoromethylate C(sp(2))-H bonds.

CHEMICAL SOCIETY REVIEWS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds

Rolando Cannalire et al.

Summary: Late stage functionalization is a powerful tool for accelerating the identification of structure-activity relationships and optimizing ADME profiles of drugs. Visible-light photocatalysis offers a smooth and clean functionalization approach for drugs, with a critical assessment of current literature and highlighting expected future progress and potential applications in the field.

CHEMICAL SOCIETY REVIEWS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Medicinal attributes of pyridine scaffold as anticancer targeting agents

Esraa Ali Mohamed et al.

Summary: Pyridine is a key heterocyclic compound with significant clinical and biological applications, particularly in the field of anticancer research. Its scaffold has shown great potential for various medicinal activities, leading to increased interest among researchers in synthesizing pyridine derivatives.

FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

添加到收藏夹

Article Chemistry, Organic

Photoredox Catalysis for Silyl-Mediated C-H Alkylation of Heterocycles with Non-Activated Alkyl Bromides

James J. Perkins et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Visible-Light-Induced ortho-Selective Migration on Pyridyl Ring: Trifluoromethylative Pyridylation of Unactivated Alkenes

Jinwon Jeon et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Differentiation and functionalization of remote C-H bonds in adjacent positions

Hang Shi et al.

NATURE CHEMISTRY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Selective C-H trifluoromethoxylation of (hetero)arenes as limiting reagent

Zhijie Deng et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Multifunctional Reagent Designed for the Site-Selective Amination of Pyridines

Patrick S. Fier et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Selective Halogenation of Pyridines Using Designed Phosphine Reagents

Jeffrey N. Levy et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Palladium-Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts

Yuan-Yuan Che et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Late-Stage Functionalization

Jonas Boergel et al.

CHEM (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

ZnMe2-Mediated, Direct Alkylation of Electron-Deficient N-Heteroarenes with 1,1-Diborylalkanes: Scope and Mechanism

Woohyun Jo et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Visible-Light-Enabled Ortho-Selective Aminopyridylation of Alkenes with N-Aminopyridinium Ylides

Yonghoon Moon et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Visible-Light-Driven C4-Selective Alkylation of Pyridinium Derivatives with Alkyl Bromides

Sungwoo Jung et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Article Chemistry, Organic

Functionalization of Pyridinium Derivatives with 1,4-Dihydropyridines Enabled by Photoinduced Charge Transfer

Inwon Kim et al.

ORGANIC LETTERS (2020)

添加到收藏夹

Review Chemistry, Organic

Good pyridine hunting: a biomimic compound, a modifier and a unique pharmacophore in agrochemicals

Vladimir V. Zakharychev et al.

Summary: The pyridine scaffold has been described as the most commercially successful heterocycle in the synthesis of plant protection chemicals in the 21st century, with the ability to modify compound properties and serve as a unique pharmacophore. Examples of pyridine intermediates used in the manufacture of agrochemicals are provided, along with explanations of the compounds' mechanisms of action when known.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS (2020)

添加到收藏夹

Review Chemistry, Organic

Recent Progress in the Functionalization of Quinoline N-Oxide

Daoqinga Dong et al.

CHINESE JOURNAL OF ORGANIC CHEMISTRY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Late stage C-H functionalization via chalcogen and pnictogen salts

Christopher B. Kelly et al.

CHEMICAL SCIENCE (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Recent Advances in Minisci-Type Reactions

Rupert S. J. Proctor et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Site-Selective Functionalization of Pyridinium Derivatives via Visible-Light-Driven Photocatalysis with Quinolinone

Inwon Kim et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Article Chemistry, Organic

Visible Light-Promoted Aliphatic C-H Arylation Using Selectfluor as a Hydrogen Atom Transfer Reagent

Hong Zhao et al.

ORGANIC LETTERS (2019)

添加到收藏夹

Article Chemistry, Physical

Cobalt-Catalyzed Alkylation of Drug-Like Molecules and Pharmaceuticals Using Heterocyclic Phosphonium Salts

Xuan Zhang et al.

ACS CATALYSIS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Late-Stage 18F-Difluoromethyl Labeling of N-Heteroaromatics with High Molar Activity for PET Imaging

Laura Trump et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photochemical C-H Hydroxyalkylation of Quinolines and Isoquinolines

Bartosz Bieszczad et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Pyridine-Pyridine Cross-Coupling Reaction via Dearomatized Radical Intermediates

J. Luke Koniarczyk et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Physical

Site-Selective C-H Acylation of Pyridinium Derivatives by Photoredox Catalysis

Sungwoo Jung et al.

ACS CATALYSIS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photoelectrochemical C-H Alkylation of Heteroarenes with Organotrifluoroborates

Hong Yan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Direct C-H Carbamoylation of Nitrogen-Containing Heterocycles

Matthieu Jouffroy et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

添加到收藏夹

Article Chemistry, Medicinal

Alkyl Sulfinates: Radical Precursors Enabling Drug Discovery

Joel M. Smith et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Mild and Direct Site-Selective sp2 C-H Silylation of (Poly)Azines

Yiting Gu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Visible-light-mediated photoredox decarbonylative Minisci-type alkylation with aldehydes under ambient air conditions

Zhongzhen Wang et al.

GREEN CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Visible-light-mediated Minisci C-H alkylation of heteroarenes with unactivated alkyl halides using O2 as an oxidant

Jianyang Dong et al.

CHEMICAL SCIENCE (2019)

添加到收藏夹

Article Chemistry, Organic

Metal-, Photocatalyst-, and Light-Free Minisci C-H Alkylation of N-Heteroarenes with Oxalates

Jianyang Dong et al.

JOURNAL OF ORGANIC CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Organic

4-Selective Pyridine Functionalization Reactions via Heterocyclic Phosphonium Salts

Ryan D. Dolewski et al.

SYNLETT (2018)

添加到收藏夹

Article Chemistry, Organic

Organocatalyzed, Visible-Light Photoredox-Mediated, One-Pot Minisci Reaction Using Carboxylic Acids via N-(Acyloxy)phthalimides

Trevor C. Sherwood et al.

JOURNAL OF ORGANIC CHEMISTRY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Site-Selective Switching Strategies to Functionalize Polyazines

Ryan D. Dolewski et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Article Chemistry, Organic

Metal-Free-Visible Light C-H Alkylation of Heteroaromatics via Hypervalent Iodine-Promoted Decarboxylation

Julien Genovino et al.

ORGANIC LETTERS (2018)

添加到收藏夹

Article Chemistry, Organic

Xanthate-Mediated Incorporation of Quaternary Centers into Heteroarenes

Vincent L. Revil-Baudard et al.

ORGANIC LETTERS (2018)

添加到收藏夹

Article Chemistry, Organic

A Strategy to Aminate Pyridines, Diazines, and Pharmaceuticals via Heterocyclic Phosphonium Salts

Chirag Patel et al.

ORGANIC LETTERS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Catalytic enantioselective Minisci-type addition to heteroarenes

Rupert S. J. Proctor et al.

SCIENCE (2018)

添加到收藏夹

Article Chemistry, Organic

Selective formation of heteroaryl thioethers via a phosphonium ion coupling reaction

Ryan G. Anderson et al.

TETRAHEDRON (2018)

添加到收藏夹

Article Chemistry, Organic

Photoredox-Mediated Minisci Alkylation of N-Heteroarenes using Carboxylic Acids and Hypervalent Iodine

Junhua Wang et al.

ASIAN JOURNAL OF ORGANIC CHEMISTRY (2018)

添加到收藏夹

Review Chemistry, Organic

Pyridinium salts: from synthesis to reactivity and applications

Subbiah Sowmiah et al.

ORGANIC CHEMISTRY FRONTIERS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Unified Approach to Couple Aromatic Heteronucleophiles to Azines and Pharmaceuticals

Ryan G. Anderson et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

添加到收藏夹

Article Chemistry, Organic

Photoredox-Mediated Direct Cross-Dehydrogenative Coupling of Heteroarenes and Amines

Jianyang Dong et al.

ORGANIC LETTERS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)-H bonds

Xinxin Wu et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Visible-Light-Induced Pyridylation of Remote C(sp3)-H Bonds by Radical Translocation of N-Alkoxypyridinium Salts

Inwon Kim et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Trimethylphosphate as a Methylating Agent for Cross Coupling: A Slow-Release Mechanism for the Methylation of Arylboronic Esters

Zhi-Tao He et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Article Chemistry, Organic

Metal-, Photocatalyst-, and Light-Free, Late-Stage C-H Alkylation of Heteroarenes and 1,4-Quinones Using Carboxylic Acids

Daniel R. Sutherland et al.

ORGANIC LETTERS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Heterobiaryl synthesis by contractive C-C coupling via P(V) intermediates

Michael C. Hilton et al.

SCIENCE (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Catalyst-free and visible light promoted trifluoromethylation and perfluoroalkylation of uracils and cytosines

Yang Huang et al.

CHEMICAL COMMUNICATIONS (2018)

添加到收藏夹

Article Chemistry, Physical

Photoredox/Bronsted Acid Co-Catalysis Enabling Decarboxylative Coupling of Amino Acid and Peptide Redox-Active Esters with N-Heteroarenes

Wan-Min Cheng et al.

ACS CATALYSIS (2017)

添加到收藏夹

Article Chemistry, Medicinal

The Necessary Nitrogen Atom: A Versatile High-Impact Design Element for Multiparameter Optimization

Lewis D. Pennington et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Bifunctional Reagent Designed for the Mild, Nucleophilic Functionalization of Pyridines

Patrick S. Fier

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Late-Stage C-H Alkylation of Heterocycles and 1,4-Quinones via Oxidative Homolysis of 1,4-Dihydropyridines

Alvaro Gutierrez-Bonet et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Ligand-accelerated non-directed C-H functionalization of arenes

Peng Wang et al.

NATURE (2017)

添加到收藏夹

Article Chemistry, Physical

Visible Light-Mediated Direct Decarboxylative C-H Functionalization of Heteroarenes

R. Aleyda Garza-Sanchez et al.

ACS CATALYSIS (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Visible-Light-Initiated Manganese Catalysis for C-H Alkylation of Heteroarenes: Applications and Mechanistic Studies

Philippe Nuhant et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

C-H Cyanation of 6-Ring N-Containing Heteroaromatics

Bryony L. Elbert et al.

CHEMISTRY-A EUROPEAN JOURNAL (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Phosphonium Salts as Pseudohalides: Regioselective Nickel-Catalyzed Cross-Coupling of Complex Pyridines and Diazines

Xuan Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

C-H Functionalization of Azines

Kei Murakami et al.

CHEMICAL REVIEWS (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

Tim Cernak et al.

CHEMICAL SOCIETY REVIEWS (2016)

添加到收藏夹

Review Chemistry, Medicinal

Pyridines and Imidazopyridines with Medicinal Significance

Tara L. S. Kishbaugh

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)

添加到收藏夹

Article Chemistry, Organic

Photoredox-Catalyzed Hydroxymethylation of Heteroaromatic Bases

Chelsea A. Huff et al.

JOURNAL OF ORGANIC CHEMISTRY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

4-Position-Selective C-H Perfluoroalkylation and Perfluoroarylation of Six-Membered Heteroaromatic Compounds

Masahiro Nagase et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Intermolecular Hydropyridylation of Unactivated Alkenes

Xiaoshen Ma et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Silyl Radical Activation of Alkyl Halides in Metallaphotoredox Catalysis: A Unique Pathway for Cross-Electrophile Coupling

Patricia Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Selective Functionalization of Pyridines via Heterocyclic Phosphonium Salts

Michael C. Hilton et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods

Peter S. Kutchukian et al.

CHEMICAL SCIENCE (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photoredox-mediated Minisci C-H alkylation of N-heteroarenes using boronic acids and hypervalent iodine

Guo-Xing Li et al.

CHEMICAL SCIENCE (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Iridium-Catalyzed Silylation of Aryl C-H Bonds

Chen Cheng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Alcohols as alkylating agents in heteroarene C-H functionalization

Jian Jin et al.

NATURE (2015)

添加到收藏夹

Review Chemistry, Applied

Recent Advances in Catalytic Functionalization of N-Oxide Compounds via C-H Bond Activation

Guobing Yan et al.

ADVANCED SYNTHESIS & CATALYSIS (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Late-Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis

Daniel A. DiRocco et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

添加到收藏夹

Article Chemistry, Medicinal

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among US FDA Approved Pharmaceuticals

Edon Vitaku et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis and Late-Stage Functionalization of Complex Molecules through C-H Fluorination and Nucleophilic Aromatic Substitution

Patrick S. Fier et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Iridium-Catalyzed C-H Borylation of Heteroarenes: Scope, Regioselectivity, Application to Late-Stage Functionalization, and Mechanism

Matthew A. Larsen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Total Syntheses of Complanadines A and B

Le Zhao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

添加到收藏夹

Review Chemistry, Multidisciplinary

Profound Methyl Effects in Drug Discovery and a Call for New C-H Methylation Reactions

Heike Schoenherr et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthetic Studies on Pseudo-Dimeric Lycopodium Alkaloids: Total Synthesis of Complanadine B

James N. Newton et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Direct Synthesis of Fluorinated Heteroarylether Bioisosteres

Qianghui Zhou et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

添加到收藏夹

Review Chemistry, Organic

An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles

Marcus Baumann et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2013)

添加到收藏夹

Review Chemistry, Multidisciplinary

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

Christopher K. Prier et al.

CHEMICAL REVIEWS (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bioconjugation by Native Chemical Tagging of C-H Bonds

Qianghui Zhou et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Radical-Based Regioselective C-H Functionalization of Electron-Deficient Heteroarenes: Scope, Tunability, and Predictability

Fionn O'Hara et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

C-H bond activation enables the rapid construction and late-stage diversification of functional molecules

Joanna Wencel-Delord et al.

NATURE CHEMISTRY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Selective C-H Fluorination of Pyridines and Diazines Inspired by a Classic Amination Reaction

Patrick S. Fier et al.

SCIENCE (2013)

添加到收藏夹

Review Radiology, Nuclear Medicine & Medical Imaging

Performance of 18F-Fluoro-Ethyl-Tyrosine (18F-FET) PET for the Differential Diagnosis of Primary Brain Tumor: A Systematic Review and Metaanalysis

Vincent Dunet et al.

JOURNAL OF NUCLEAR MEDICINE (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

Mechanistic Studies on Direct Arylation of Pyridine N-Oxide: Evidence for Cooperative Catalysis between Two Distinct Palladium Centers

Yichen Tan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

A New Reagent for Direct Difluoromethylation

Yuta Fujiwara et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Practical and innate carbon-hydrogen functionalization of heterocycles

Yuta Fujiwara et al.

NATURE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Innate C-H trifluoromethylation of heterocycles

Yining Ji et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

Minisci reactions: Versatile CH-functionalizations for medicinal chemists

Matthew A. J. Duncton

MEDCHEMCOMM (2011)

添加到收藏夹

Article Chemistry, Multidisciplinary

Highly Selective Metalations of Pyridines and Related Heterocycles Using New Frustrated Lewis Pairs or tmp-Zinc and tmp-Magnesium Bases with BF3 center dot OEt2

Milica Jaric et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

Total Synthesis of (+)-Complanadine A Using an Iridium-Catalyzed Pyridine C-H Functionalization

Daniel F. Fischer et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

Direct C-H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids

Ian B. Seiple et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

添加到收藏夹

Article Chemistry, Medicinal

7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation

Mingzong Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

添加到收藏夹

Article Chemistry, Organic

Preparation of Heteroaryloxetanes and Heteroarylazetidines by Use of a Minisci Reaction

Matthew A. J. Duncton et al.

JOURNAL OF ORGANIC CHEMISTRY (2009)

添加到收藏夹

Article Chemistry, Multidisciplinary

Meta halogenation of 1,3-disubstituted arenes via iridium-catalyzed arene borylation

Jaclyn M. Murphy et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

添加到收藏夹

Article Chemistry, Organic

Anionic, in situ generation of formaldehyde: A very useful and versatile tool in synthesis

Geoffrey Deguest et al.

ORGANIC LETTERS (2007)

添加到收藏夹

Review Chemistry, Multidisciplinary

Pyridine elaboration through organometallic intermediates: regiochemical control and completeness

Manfred Schlosser et al.

CHEMICAL SOCIETY REVIEWS (2007)

添加到收藏夹

Article Chemistry, Multidisciplinary

A solution to the 2-pyridyl organometallic cross-coupling problem:: Regioselective catalytic direct arylation of pyridine N-oxides

LC Campeau et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.