Is Baikiain in Tara Flour a Causative Agent for the Adverse Events Associated with the Recalled Frozen French Lentil & Leek Crumbles Food Product?-A Working Hypothesis

The French Lentil & Leek Crumbles frozen food productwas recentlyrecalled due to reports of gastrointestinal issues. So far, 393 adverseillness complaints and 133 hospitalizations have been reported fromconsumption of this food, and the tara (Tara spinosa) protein flour ingredient is hypothesized to be responsible. A multiprongedapproach resulted in identification of (S)-(-)-baikiainin tara as a compound of interest due to its abundance, possible metabolicfate, and close resemblance to irreversible inhibitors of L-pipecolate oxidase. Oral administration of baikiain inND4 mice showed a statistically significant increase in blood ALTlevels and a reduction in liver GSH.

Automated summary

The French Lentil & Leek Crumbles frozen food product has been recalled due to gastrointestinal issues, with 393 adverse illness complaints and 133 hospitalizations reported. The Tara protein flour ingredient is believed to be the cause. A compound called (S)-(-)-baikiainin tara was identified as a compound of interest, with potential implications on liver health.