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In situ self-assembled nanomedicines for cancer treatment

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Oncology

Artificial intelligence aids in development of nanomedicines for cancer management

Ping Tan et al.

Summary: In the past decade, nanomedicine has seen unprecedented development in disease diagnosis and treatment. Several nanomedicines have been approved for clinical use, demonstrating the potential value of transitioning nanotechnology-modified medicines from the lab to the bedside. The application of artificial intelligence (AI) in the development of nanotechnology-based products has the potential to transform healthcare by enabling the acquisition and analysis of large datasets and tailoring precision nanomedicines for cancer management.

SEMINARS IN CANCER BIOLOGY (2023)

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Article Multidisciplinary Sciences

Molecularly self-fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke

Hongyuan Zhang et al.

Summary: In this study, the authors developed a self-propelling nano-penetrator assembled with a photothermal photosensitizer and a photothermal-activable NO donor. The nano-penetrator showed advantages in terms of NO productivity and autonomous motion under laser irradiation. In animal models, it successfully navigated to thrombus, penetrated deep into the clot, and achieved effective thrombolysis and prevention of thrombosis recurrence and ischemic stroke.

NATURE COMMUNICATIONS (2023)

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Article Chemistry, Multidisciplinary

Camouflaged Virus-Like-Nanocarrier with a Transformable Rough Surface for Boosting Drug Delivery

Hongyue Yu et al.

Summary: A camouflaged virus-like nanocarrier with a transformable rough surface composed of a mesoporous SiO2 nanoparticle and an acid-responsive polymer is reported. Under normal pH conditions, the spikes on the nanocarrier are hidden by the polymer shell, inhibiting non-specific strong nano-bio interactions. In an acidic tumor microenvironment, the nanocarrier sheds the polymer camouflage to expose its rough surface, improving retention ability and endocytosis efficiency. The rationally designed nanocarrier exhibits extended blood circulation time and enhanced tumor accumulation due to its dynamically variable rough surface.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

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Article Engineering, Biomedical

A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody

Zhilin Li et al.

Summary: To improve the response rate of immune checkpoint inhibitors in immunosuppressive cancers, a self-amplified biomimetic nanosystem was constructed to induce immunogenic cell death at tumor sites. The nanosystem effectively reverses the immunosuppressive tumor microenvironment, leading to distinctive inhibition of tumor growth and metastasis when combined with immune checkpoint inhibitors.

BIOACTIVE MATERIALS (2023)

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Article Engineering, Environmental

Self-engineered lipid peroxidation nano-amplifier for ferroptosis-driven antitumor therapy

Xinxin Sun et al.

Summary: This study presents a novel lipid peroxidation nano-amplifier based on a drug-deliver-drug (DDD) engineering strategy for efficient ferroptosis induction in cancer therapy. The nano-amplifier is formed by co-assembling a GPX4 inhibitor (FIN56) and arachidonic acid (AA) into stable nanoparticles without any excipients. Additionally, a disulfide bond-containing amphipathic PEG polymer is decorated on the nano-amplifier for long blood circulation and tumor-specific drug release. The AA not only generates abundant lipid reactive oxygen species (ROS), but also induces membranous lipid peroxidation in tumor cells, synergistically inducing tumor ferroptosis with FIN56-mediated GPX4 depletion. The nano-amplifier demonstrates potent ferroptosis-driven antitumor activity in mice with breast tumors. This study provides a conceptual advance in ferroptosis-driven nanotherapeutics and offers a novel DDD co-delivery paradigm for combination cancer therapy.

CHEMICAL ENGINEERING JOURNAL (2023)

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Review Materials Science, Multidisciplinary

Platelet-Inspired Nanotherapeutics for Biomedical Applications

Fujun Yang et al.

Summary: Platelets, as abundant corpuscles in the blood, play important roles in normal physiological processes and disease occurrence. In recent years, significant progress has been made in platelet-inspired nanotherapeutics, especially in the fields of biotechnology and nanomedicine. This article provides an overview of platelet-inspired nanotherapeutics for biomedical applications. It discusses the recent trends of biomimetic platelet-inspired nanosystems, the functional modulation of platelet aggregation, activation, and inhibition, platelet derivative-based nanotherapeutics, and the clinical application prospects of these emerging nanotherapeutics with their rationale, advantages, and challenges highlighted.

ACS MATERIALS LETTERS (2023)

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Article Chemistry, Multidisciplinary

Tailoring a Near-Infrared Macrocyclization Scaffold Allows the Control of In Situ Self-Assembly for Photoacoustic/PET Bimodal Imaging

Yuqi Wang et al.

Summary: The article introduces a method of designing activatable molecular imaging probes through enzyme-triggered macrocyclization and in situ self-assembly. By controlling macrocyclization and self-assembly, a caspase-3-activatable PA/PET bimodal probe was successfully designed for in vivo imaging of tumor apoptosis. This probe combines the advantages of PET and PA, providing a promising tool for the early evaluation of antitumor efficacy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Multidisciplinary

In Situ Self-Assembly of Bispecific Peptide for Cancer Immunotherapy

Man-Di Wang et al.

Summary: This study reports a programmable peptide molecule that enables specific and efficient assembly by binding to targeting receptor proteins. By designing different peptide sequences and receptor bindings, it is possible to promote oligomerization and functional regulation of protein complexes.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Review Chemistry, Multidisciplinary

Supramolecular Self-Assembly in Living Cells

Mohamed Dergham et al.

Summary: In cellulo supramolecular self-assembly, based on non-covalent forces, provides an accurate and controllable method to regulate cell properties and biological functions. It utilizes host-guest interactions, pH changes, enzymes, and polymerization-induced self-assembly to induce various unnatural reactions without disrupting natural biological processes.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Multidisciplinary

Cathespin B-Initiated Cypate Nanoparticle Formation for Tumor Photoacoustic Imaging

Chenchen Wang et al.

Summary: CTSB is overexpressed in many types of cancer in the early stage, and the smart photoacoustic probe Cypate-CBT can achieve sensitive and specific detection of CTSB activity, showing intracellular accumulation after self-assembly initiated by CTSB. It is expected to be an effective PA imaging agent for early cancer diagnosis.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Multidisciplinary

Precisely engineering a dual-drug cooperative nanoassembly for proteasome inhibition-potentiated photodynamic therapy

Fujun Yang et al.

Summary: This study presents a facile dual-drug nanoassembly that enhances the efficacy of photodynamic therapy by inhibiting the proteasome. The engineered nanoassembly demonstrates multiple advantages, including simple fabrication, high drug co-loading efficiency, flexible dose adjustment, and favorable stability and enrichment.

CHINESE CHEMICAL LETTERS (2022)

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Article Chemistry, Physical

Flowerlike BiOCl nanospheres fabricated by an in situ self-assembly strategy for efficiently enhancing photocatalysis

Cheng Liu et al.

Summary: Defect engineering has been proven as an efficient approach to enhance the photocatalytic performance in semiconductor-based photocatalytic reactions. In this work, a synergistically PVP/EG-assisted in situ self-assembly strategy was successfully developed for preparing flowerlike BiOCl nanospheres with abundant oxygen vacancies. The nanospheres showed a twice higher photocatalytic conversion of benzylamine than BiOCl nanosheets under visible light, attributed to more active sites and improved selectivity for photooxidation.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Chemistry, Multidisciplinary

In Situ Hypoxia-Induced Supramolecular Perylene Diimide Radical Anions in Tumors for Photothermal Therapy with Improved Specificity

Hua Wang et al.

Summary: The study presents a hypoxia-induced specific photothermal therapy using supramolecular perylene diimide radical anions, which shows excellent photothermal therapeutic efficiency, specificity, and biological safety. After the treatment, the hypoxia inducible factor expression of tumors decreases to the normal level, indicating the potential of the strategy in improving specificity and safety of photothermal therapy for hypoxic tumors.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Chemistry, Multidisciplinary

Quantitative Detection of In Vivo Aggregation Degree for Enhanced M2 Macrophage MR Imaging

Lu-Jun Luo et al.

Summary: In this study, a sensitive and quantitative MRI method was developed to calculate the aggregation degree (α(agg)), which showed a high fitting degree with the gold standard fluorescence method and contributed to enhanced T-1-weighted MR imaging of M2 macrophages in tumors.

NANO LETTERS (2022)

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Article Chemistry, Physical

NIR-II photothermal therapy for effective tumor eradication enhanced by heterogeneous nanorods with dual catalytic activities

Linghua Zhang et al.

Summary: This study proposes a facile approach to produce heterogeneous nanorods that can solve the bottleneck problems of photothermal therapy (PTT) and completely eliminate tumors in animal models without toxic side effects.

NANO RESEARCH (2022)

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Review Chemistry, Multidisciplinary

Self-assembly of artificial architectures in living cells - design and applications

Xiaolei Sun et al.

Summary: Self-assembly is widely present in natural living systems and artificial synthetic material systems. The recent progress in artificial self-assembly in living cells focuses on constructing dynamic assemblies that respond to intracellular stimuli in order to regulate morphology, behavior, and fate of living cells. This advancement in artificial self-assembly is believed to elaborate the molecular mechanisms in cells and further promote biological and medical-related applications in the future.

SCIENCE CHINA-CHEMISTRY (2022)

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Article Medicine, Research & Experimental

Simultaneous enhancement of T1 and T2 magnetic resonance imaging of liver tumor at respective low and high magnetic fields

Huan Li et al.

Summary: This study found that a gadolinium nanoparticle, instructed by gamma-glutamyl transpeptidase (GGT) and formed intracellularly, exhibits different magnetic resonance properties at low and high magnetic fields, making it suitable for enhancing T-1 and T-2 MRI imaging of liver tumors respectively.

THERANOSTICS (2022)

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Article Medicine, Research & Experimental

Smart NIR-II croconaine dye-peptide for enhanced photo-sonotheranostics of hepatocellular carcinoma

Shuang Li et al.

Summary: A pH-sensitive self-assembling Glypican-3-binding peptide (GBP) dye was developed as an intelligent nanoprobe for precise imaging and therapy of hepatocellular carcinoma (HCC). The nanoprobe showed advantages such as pH-responsive aggregation, enhanced imaging and therapeutic effects, and safe excretion. This self-assembling small molecule strategy provides a simple and efficient solution for HCC theranostics.

THERANOSTICS (2022)

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Article Chemistry, Multidisciplinary

Elaborately Engineering a Self-Indicating Dual-Drug Nanoassembly for Site-Specific Photothermal-Potentiated Thrombus Penetration and Thrombolysis

Zhiqiang Zhao et al.

Summary: This study proposes a method of using photothermal therapy to overcome the challenges of conventional thrombolytic treatments, achieving thrombus-targeted delivery through nanoscale assembly, and demonstrating high therapeutic efficacy.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

Lina Feng et al.

Summary: A strategy of acceptor planarization and donor rotation was proposed to design type I photosensitizers (PSs) and photothermal reagents for tumor therapy. Experimental results showed that nanoparticles with the most rotors exhibited the highest photothermal conversion efficiency, making them suitable for NIR fluorescence imaging-guided synergistic therapy.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

An Electroluminodynamic Flexible Device for Highly Efficient Eradication of Drug-Resistant Bacteria

Jianhong Zhang et al.

Summary: Photodynamic therapy (PDT) has been widely recognized for its advantages in antibacterial applications. This study introduces a conceptually antibacterial strategy called electroluminodynamic therapy (ELDT), which uses an electroluminescent (EL) material and a photosensitizer to generate reactive oxygen species (ROS) under an electric field. The ELDT-based flexible therapeutic device proves to be effective in killing drug-resistant bacteria and promoting wound healing.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

A Dendritic Polymer-Based Nanosystem Mediates Drug Penetration and Irreversible Endoplasmic Reticulum Stresses in Tumor via Neighboring Effect

Xiuli Zheng et al.

Summary: This study developed pH/redox-responsive dendritic polymer-based nanoparticles (NPs) to enhance drug penetration and induce cell apoptosis through combination therapy. By amplifying the neighboring effect, the NPs were able to diffuse through the dense tumor extracellular matrix and penetrate solid tumors, effectively eradicating them.

ADVANCED MATERIALS (2022)

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Article Engineering, Biomedical

Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy

Shenwu Zhang et al.

Summary: Immunotherapy is a promising cancer treatment, but its efficacy for immune-cold tumors is not satisfactory. Photodynamic therapy can effectively induce immunogenic cell death, and the use of nanotechnology enhances the effectiveness of cancer immunotherapy. This article reviews recent advances in photodynamic therapy, nanotechnology, and immunogenic cell death, and discusses the prospects and challenges in this field.

BIOMATERIALS (2022)

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Article Chemistry, Multidisciplinary

In Situ Self-Sorting Peptide Assemblies in Living Cells for Simultaneous Organelle Targeting

Xin Liu et al.

Summary: Self-sorting peptide assemblies responsive to GSH were developed within cancer cells, enabling simultaneous organelle targeting, organelle dysfunction, and cell death. This provides a unique strategy for drug targeting delivery and modulating biological processes in the future.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Multidisciplinary Sciences

Bioorthogonal in situ assembly of nanomedicines as drug depots for extracellular drug delivery

Ziyang Cao et al.

Summary: The authors have developed drug loaded nanoparticle that enlarges upon contact with internal tumor cell environment, leading to improved drug retention in cancer cells. They used a bioorthogonal in situ assembly strategy to form micro-sized drug depots within the tumor area, enhancing drug retention and sustained release. This strategy improves the efficacy of anticancer drugs and enables cocktail chemoimmunotherapy.

NATURE COMMUNICATIONS (2022)

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Article Medicine, Research & Experimental

Acidic microenvironment triggered in situ assembly of activatable three-arm aptamer nanoclaw for contrast-enhanced imaging and tumor growth inhibition in vivo

Jin Huang et al.

Summary: This study proposes an acidic tumor microenvironment triggered assembly of a multivalent nanodevice that can improve tumor imaging and therapy.

THERANOSTICS (2022)

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Article Nanoscience & Nanotechnology

One-Step In Situ Self-Assembly of Biodegradable Films for Long-Term Intravesical Bladder Cancer Therapy

Guangyu Wu et al.

Summary: Intravesical instillation therapy is a common treatment strategy for bladder cancer, but the rapid clearance of chemotherapy drugs through urination limits their efficacy. A drug-loaded thin film made of tannic acid (TA) and ferric ions (Fe3+) was developed to overcome this issue. The film effectively prolonged the drug's residence time in the bladder and enabled sustained release, improving therapeutic efficacy. The film exhibited good biocompatibility and antibacterial properties, making it a potential platform for treating various bladder diseases.

ACS APPLIED BIO MATERIALS (2022)

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Article Nanoscience & Nanotechnology

In Situ Nanoparticle Self-Assembly for Combination Delivery of Therapeutics to Non-Small Cell Lung Cancer

Elham Hatami et al.

Summary: This study developed an injectable formulation that can deliver gambogic acid and gemcitabine simultaneously, achieving synergistic effects and reducing toxicity in lung cancer treatment. The formulation demonstrated superior therapeutic activity and precise tumor targeting in vitro and in vivo.

ACS APPLIED BIO MATERIALS (2022)

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Review Nanoscience & Nanotechnology

Recent advances in development of dendriticpolymer-basednanomedicines for cancer diagnosis

Haonan Li et al.

Summary: Dendritic polymers with highly branched three-dimensional architectures and low viscosity have great potential in various biomedical applications. Despite most review articles focusing on drug or gene delivery, there is still a lack of discussion on their function as cancer diagnosis agents.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Tumor Microenvironment Responsive Head-to-Foot Self-Assembly Nanoplatform for Positron Emission Tomography Imaging in Living Subjects

Ling Qiu et al.

Summary: The study presents a novel PET tracer [F-18]1 targeting cancer-associated receptors, which forms nanoparticles through self-assembly and enhances retention and uptake in target tissues, showing promise for accurately detecting BR-positive cancers. The tumor microenvironment responsive self-assembly nanoplatform holds potential for developing other smart molecular probes.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Tumor Receptor-Mediated In Vivo Modulation of the Morphology, Phototherapeutic Properties, and Pharmacokinetics of Smart Nanomaterials

Lu Zhang et al.

Summary: This study reports the development of a smart peptidic nanophototherapeutic agent that can transform its morphology at tumor sites, leading to enhanced photothermal and photodynamic properties and effective elimination of breast cancer in mice. The technology of nanomaterial modulation based on living cell surface receptors shows great potential for improving therapeutic efficacy against various cancers.

ACS NANO (2021)

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Article Oncology

Sonodynamic therapy-derived multimodal synergistic cancer therapy

Mimi Xu et al.

Summary: Sonodynamic therapy (SDT) offers a promising approach for non-invasively eliminating solid tumors, and combining it with other therapeutic methods can enhance tumor treatment effects. The potential of SDT-based synergistic therapeutics is highlighted for precision tumor treatment medicine.

CANCER LETTERS (2021)

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Article Engineering, Biomedical

Targeted in situ self-assembly augments peptide drug conjugate cell-entry efficiency

Man-Di Wang et al.

Summary: PDC drugs offer advantages of improved drug targetability and reduced adverse effects compared to traditional chemotherapy, but their poor permeability to tumor cells needs to be addressed. The designed PDC drug molecule forms nanoclusters upon binding cellular receptor, enhancing treatment efficacy. This strategy leverages assembly principles to promote peptide penetration into cells and increase intracellular drug bioavailability.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

In Situ Self-Assembly Nanomicelle Microneedles for Enhanced Photoimmunotherapy via Autophagy Regulation Strategy

Minglong Chen et al.

Summary: An in situ self-assembled nanomicelle dissolving micro-needle patch was designed for intralesional delivery of immunogenic cell death-inducer and autophagy inhibitor for efficient antitumor therapy. The patch, with photothermal properties, effectively penetrates deep tumor tissue, precisely ablating tumors, and reshaping the tumor immunosuppressive microenvironment.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Alkaline Phosphatase Enabled Fluorogenic Reaction and in situ Coassembly of Near-Infrared and Radioactive Nanoparticles for in vivo Imaging

Yuxuan Hu et al.

Summary: This study presents an enzyme-activatable probe for high sensitivity bimodal imaging of tumors, utilizing an enzyme-induced reaction and coassembly strategy. The method significantly enhances NIR FL and radioactivity imaging sensitivity, facilitating the differentiation of tumor foci from normal tissues in vivo.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

In vivo self-assembled nanomedicine

Muhetaerjiang Mamuti et al.

Summary: The emergence of nanomedicine has significantly improved the pharmacokinetics of conventional therapeutic agents. However, biological barriers and changes in stability and surface properties during transportation hinder its clinical translation. Therefore, a strategy of in vivo self-assembly has been proposed to overcome these challenges and enhance targeted accumulation towards disease sites.

NANO TODAY (2021)

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Article Chemistry, Multidisciplinary

Light-Controlled Nanosystem with Size-Flexibility Improves Targeted Retention for Tumor Suppression

Huanhuan Luo et al.

Summary: This study successfully constructed a nanosystem that can modulate particle size using near-infrared light, providing better tumor targeting with its small size advantage and enhanced cellular uptake through NIR irradiation-induced PEG shedding. The nanosystem forms larger particles inside the tumor, prolonging retention time and producing enhanced targeted therapeutic effects.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

In Situ Supramolecular Self-Assembly of Pt(IV) Prodrug to Conquer Cisplatin Resistance

Qian Wang et al.

Summary: This study introduces a synergistic Pt(IV) prodrug that combines dual responsive behavior and dual drug resistance-related pathways deactivation, effectively overcoming drug resistance and improving the efficacy of anticancer drugs through multiple mechanisms.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Enzyme-Mediated In Situ Self-Assembly Promotes In Vivo Bioorthogonal Reaction for Pretargeted Multimodality Imaging

Yuxuan Hu et al.

Summary: By combining enzyme-mediated fluorogenic reaction and in situ self-assembly with the inverse electron demand Diels-Alder (IEDDA) reaction, an activatable pretargeted strategy for multimodality imaging has been developed. This strategy allows for amplification of NIR FL and MRI signals, enrichment of TCOs, and simultaneous achievement of strong NIR FL, MRI, and PET signals for pretargeted multimodality imaging of ALP activity.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Nanoscience & Nanotechnology

Cancer nanotechnology: current status and perspectives

Jessica A. Kemp et al.

Summary: Modern medicine has been fighting against cancer for nearly a century with no clear end in sight. The need to increase specificity and decrease systemic toxicities in cancer treatments remains. Nanotechnology shows potential in revolutionizing diagnostic tools and improving patient care in cancer treatment.

NANO CONVERGENCE (2021)

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Article Pharmacology & Pharmacy

Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy

Shenwu Zhang et al.

Summary: This study demonstrates the development of a core-matched nanoassembly that shows the self-assembly capability of pure PPa molecules into NPs and the improvement of stability and antitumor activity by PPa-PEG(2K).

ACTA PHARMACEUTICA SINICA B (2021)

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Article Chemistry, Multidisciplinary

In Vivo Self-Assembly Induced Cell Membrane Phase Separation for Improved Peptide Drug Internalization

Ruo-Chen Guo et al.

Summary: A novel in vivo self-assembly strategy is developed to induce phase separation of cell membrane, improving the internalization of therapeutic peptides and enhancing drug delivery efficacy, particularly in cancer therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Polymer Science

Light-Click In Situ Self-Assembly of Superhelical Nanofibers and Their Helicity Hierarchy Control

Liang Chen et al.

Summary: The new in situ self-assembly method, light-click in situ self-assembly, enables simultaneous polymer coupling and self-assembly through photoclick chemistry, resulting in the direct synthesis of helical nanostructures with chiral bias, including complex superhelical fibers. Quantifying the relationship between reaction conversion and resulting morphology can establish a full phase diagram of helical self-assembly, allowing temporal control of helicity hierarchy through light stimulus.

MACROMOLECULES (2021)

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Review Gastroenterology & Hepatology

Pancreatic cancer: A review of epidemiology, trend, and risk factors

Jian-Xiong Hu et al.

Summary: Pancreatic cancer remains highly lethal with low survival rates and difficulty in early detection. The incidence and mortality of pancreatic cancer are increasing worldwide, and understanding the risk factors is crucial for prevention.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

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Article Medicine, Research & Experimental

Photosensitizer-driven nanoassemblies of homodimeric prodrug for self-enhancing activation and synergistic chemo-photodynamic therapy

Shenwu Zhang et al.

Summary: Carrier-free prodrug-nanoassemblies composed of homodimeric prodrugs driven by a photosensitizer have been developed for self-enhancing activation and chemo-photodynamic synergistic therapy. The nanoassemblies demonstrated potent antitumor activity in a 4T1 breast cancer BALB/c mice xenograft model through alleviating the aggregation-caused quenching effect and synergistically promoting prodrug activation using endogenous and externally induced reactive oxygen species.

THERANOSTICS (2021)

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Review Nanoscience & Nanotechnology

Self-Assembled Peptide Drug Delivery Systems

Jia Yang et al.

Summary: Peptides can be used as modules to construct self-assembled peptide nanomaterials, which have the potential to reduce drug toxicity, improve drug targeting, and enhance drug delivery efficiency. Different strategies for designing peptide nanomaterials, including ex situ construction, in situ morphological transformation, and in situ construction of peptide drug delivery systems, can be used for drug delivery.

ACS APPLIED BIO MATERIALS (2021)

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Review Materials Science, Biomaterials

Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity

Yuqi Wang et al.

Summary: This review summarizes recent advances in the development of different modality imaging probes based on in situ self-assembly strategy for in vivo imaging of enzymatic activity. It discusses the applications of stimuli-mediated proteolysis and stimuli-triggered biocompatible reaction in designing fluorescence, MRI, PET, PA, and bimodality imaging probes for in vivo imaging of different enzymes. Challenges and prospects in the stimuli-responsive in situ self-assembly strategy for in vivo imaging are also discussed.

BIOMATERIALS SCIENCE (2021)

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Article Chemistry, Multidisciplinary

In situ formation of tetraphenylethylene nano-structures on microgels inside living cells via reduction-responsive self-assembly

Wenbo Zhang et al.

Summary: The study introduces a novel strategy for the in situ formation of self-assembled micro-nano composite structures in a cell milieu using reduction-responsive microgels as a platform. Nano-spikes were formed on the microgels in the presence of reductive agents, and the composite structures were observed by enhanced fluorescence intensity and direct transmission electron microscopy.

NANOSCALE (2021)

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Article Chemistry, Multidisciplinary

A Near-Infrared Peptide Probe with Tumor-Specific Excretion-Retarded Effect for Image-Guided Surgery of Renal Cell Carcinoma

Hong-Wei An et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Pre-targeted Imaging of Protease Activity through In Situ Assembly of Nanoparticles

Zixin Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

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Review Chemistry, Multidisciplinary

Ferroptosis-driven nanotherapeutics for cancer treatment

Xinzhu Shan et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Nanoscience & Nanotechnology

Structure-Switchable DNA Programmed Disassembly of Nanoparticles for Smart Size Tunability and Cancer-Specific Drug Release

Wanying Ye et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Chemistry, Multidisciplinary

Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors

Yanan Li et al.

CHINESE CHEMICAL LETTERS (2020)

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Article Chemistry, Multidisciplinary

Delivery of triptolide with reduction-sensitive polymer nanoparticles for liver cancer therapy on patient-derived xenografts models

Mengxue He et al.

CHINESE CHEMICAL LETTERS (2020)

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Review Chemistry, Medicinal

Emerging carrier-free nanosystems based on molecular self-assembly of pure drugs for cancer therapy

Xuanbo Zhang et al.

MEDICINAL RESEARCH REVIEWS (2020)

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Article Multidisciplinary Sciences

A biomimetic platelet based on assembling peptides initiates artificial coagulation

Pei-Pei Yang et al.

SCIENCE ADVANCES (2020)

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Article Chemistry, Multidisciplinary

Tumor-Microenvironment-Activated In Situ Self-Assembly of Sequentially Responsive Biopolymer for Targeted Photodynamic Therapy

Xuan Wang et al.

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Article Chemistry, Multidisciplinary

An All-Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging-Guided Synergistic Therapy

Zhijun Zhang et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Construction of triblock copolymer-gold nanorod composites for fluorescence resonance energy transfer via pH-sensitive allosteric

Li Zeng et al.

CHINESE CHEMICAL LETTERS (2020)

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Article Engineering, Biomedical

Targeting self-assembly peptide for inhibiting breast tumor progression and metastasis

Shi Luo et al.

BIOMATERIALS (2020)

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Article Pharmacology & Pharmacy

Selectively enhancing radiosensitivity of cancer cells via in situ enzyme-instructed peptide self-assembly

Yang Gao et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Multidisciplinary Sciences

Ultrasound-Activated Cascade Effect for Synergistic Orthotopic Pancreatic Cancer Therapy

Dong-Bing Cheng et al.

ISCIENCE (2020)

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Article Chemistry, Multidisciplinary

Furin-Instructed Intracellular Gold Nanoparticle Aggregation for Tumor Photothermal Therapy

Jihua Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Medicine, General & Internal

Pancreatic cancer

Jonathan D Mizrahi et al.

LANCET (2020)

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Review Engineering, Biomedical

Emerging nanotherapeutics for antithrombotic treatment

Zhiqiang Zhao et al.

BIOMATERIALS (2020)

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Review Oncology

Clinical development and potential of photothermal and photodynamic therapies for cancer

Xingshu Li et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Multidisciplinary Sciences

Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy

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