期刊
CHEMICAL ENGINEERING JOURNAL
卷 460, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2023.141852
关键词
Melanin nanoparticles; Injectable polysaccharide hydrogels; Reactive oxygen species; Photothermal antibacterial therapy; Diabetic wounds
A hydrogel (GCM) wound dressing loaded with melanin nanoparticles in a polysaccharide matrix has been developed for efficient healing of bacterially infected diabetic wounds. The GCM hydrogel can rapidly stop bleeding, neutralize inflammatory cytokines, and promote the transition from inflammation to wound healing. It also enhances cell proliferation, migration, and angiogenesis, making it a potential treatment option for various bacteria-infected diabetic wounds.
Owing to hyperglycemia-related metabolic abnormalities that cause oxidative stress, recurrent infections, and vascular lesions, the therapeutic management of diabetic wounds is still unsatisfactory. Herein, we present a hydrogel (GCM) wound dressing loaded with melanin nanoparticles in a polysaccharide matrix (biguanide chitosan and oxidized beta-glucan) for efficient healing of bacterially infected diabetic wounds. By a simple local injection, a protective GCM hydrogel barrier is established over the wound to rapidly stop bleeding and neutralize inflammatory cytokines. Subsequently, the GCM hydrogel achieves an accelerated transfer from the inflammatory process to the healing phase of the wound because of its excellent photothermal antimicrobial and reactive oxygen species scavenging properties. Additionally, GCM hydrogel has a three-dimensional network structure that dramatically enhances cell proliferation, migration, and angiogenesis by creating favorable ecological conditions for cell survival. Notably, our GCM hydrogel can help treat a variety of bacteria-infected diabetic wounds like skin and oral ulcer wounds. Collectively, this work provides a new option for diabetic wound treatment.
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