Therapeutic efficacy of caffeic acid phenethyl ester in cancer therapy: An updated review

Nowadays, there is a lot of public and scientific interest in using phytochemicals to treat human ailments. Existing cancer medicines still run across obstacles, despite significant advancements in the field. For instance, chemotherapy may result in severe adverse effects, increased drug resistance, and treatment failure. Natural substances that are phytochemically derived provide innovative approaches as potent therapeutic molecules for the treatment of cancer. Bioactive natural compounds may enhance chemotherapy for cancer by increasing the sensitivity of cancer cells to medicines. Propolis has been found to interfere with the viability of cancer cells, among other phytochemicals. Of all the components that make up propolis, caffeic acid phenethyl ester (CAPE) (a flavonoid) has been the subject of the most research. It demonstrates a broad spectrum of therapeutic uses, including antitumor, antimicrobial, antiviral, anti-inflammatory, immunomodulatory, hepatoprotective, neuroprotective, and cardioprotective effects. Studies conducted in vitro and in vivo have demonstrated that CAPE specifically targets genes involved in cell death, cell cycle regulation, angiogenesis, and metastasis. By altering specific signaling cascades, such as the NF-kappa B signaling pathway, CAPE can limit the proliferation of human cancer cells. This review highlights the research findings demonstrating the anticancer potential of CAPE with a focus on multitargeted molecular and biological implications in various cancer models.

Automated summary

Currently, there is great interest in using phytochemicals for treating human ailments. Despite advancements in cancer medicine, there are still obstacles such as severe side effects and drug resistance linked to chemotherapy. Phytochemically derived compounds, like caffeic acid phenethyl ester (CAPE) found in propolis, show promise as a potent therapeutic molecule for cancer treatment. Research has shown that CAPE has various therapeutic effects and can specifically target genes involved in cell death, cell cycle regulation, angiogenesis, and metastasis, limiting the proliferation of human cancer cells.