Temporal hierarchy of cortical responses reflects core-belt-parabelt organization of auditory cortex in musicians

Human auditory cortex (AC) organization resembles the core-belt-parabelt organization in nonhuman primates. Previous studies assessed mostly spatial characteristics; however, temporal aspects were little considered so far. We employed co-registration of functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) in musicians with and without absolute pitch (AP) to achieve spatial and temporal segregation of human auditory responses. First, individual fMRI activations induced by complex harmonic tones were consistently identified in four distinct regions-of-interest within AC, namely in medial Heschl's gyrus (HG), lateral HG, anterior superior temporal gyrus (STG), and planum temporale (PT). Second, we analyzed the temporal dynamics of individual MEG responses at the location of corresponding fMRI activations. In the AP group, the auditory evoked P2 onset occurred similar to 25 ms earlier in the right as compared with the left PT and similar to 15 ms earlier in the right as compared with the left anterior STG. This effect was consistent at the individual level and correlated with AP proficiency. Based on the combined application of MEG and fMRI measurements, we were able for the first time to demonstrate a characteristic temporal hierarchy (chronotopy) of human auditory regions in relation to specific auditory abilities, reflecting the prediction for serial processing from nonhuman studies.

Automated summary

We used co-registration of fMRI and MEG to investigate the temporal segregation of human auditory responses in musicians with and without absolute pitch. Our findings reveal a characteristic temporal hierarchy of auditory regions in relation to specific auditory abilities, supporting the hypothesis of serial processing from nonhuman studies.