4.7 Article

Fabrication and in vitro characterization of antibacterial magneto-luminescent core-shell bioactive glass nanoparticles

期刊

CERAMICS INTERNATIONAL
卷 49, 期 12, 页码 20118-20126

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ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2023.03.135

关键词

Bioactive glass; Core; shell nanoparticles; Antibacterial; Luminescence; Magnetic; Europium

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By synthesizing antibacterial magneto-luminescent 58S bioactive glasses, which possess magnetic and luminescent properties, this study showed that they can effectively target and localize at the infection foci without dispersing into the body. The Eu doped SPION/Bioactive glass nanoparticles exhibited increased osteoblast viability and inhibited bacterial growth, while possessing superparamagnetic properties and exhibiting red luminescence.
When nanomaterials with antibacterial properties were sent to the infected area, it was predicted that infection and related complications could be prevented. The nanoparticles can be designed to possess magnetic and luminescence (magneto-luminescent) properties to be effectively targeted and localized at the infection foci without dispersing into the body. Simultaneously, the magneto-luminescent characteristic of particles allows visualization and confirmation of localized particles at the desired area. In this regard, there are no studies on the use of antibacterial magneto-luminescent bioactive glass for orthopedic applications and the treatment of or-thopedic device-related infections. In this study, antibacterial magneto-luminescent 58S bioactive glasses were synthesized by the modified Sto center dot ber using coupled with a layer-by-layer assembly approach to possess core/shell particle morphology. SPION/Bioactive glass nanoparticles had an average size of 50 nm and displayed super -paramagnetic behavior. While the saturation magnetization value (sigma s) of the undoped 58S sample was 25.32 emu/g, that of the co-doped sample (2% Eu, 2% Zn) was 21.74 emu/g; this showed that the doping slightly reduced the magnetization value. Europium (Eu) doping of SPION/Bioactive glass nanoparticles induced char-acteristic red emission originating from Eu emissions belonging to 5D0-7FJ (J = 1-4) transitions and the strongest peak was at 612 nm (electric-dipole transition, 5D0-7F2). Color chromaticity coordinates confirmed emission in the red region. XPS spectrum revealed the existence of Eu and Zn dopant elements in 58S bioactive glass. After soaking characteristic peaks at 31.74 degrees and 45.43 degrees belonging to the hexagonal hydroxyapatite phase were detected in the XRD data, confirming the SEM images. 2% Eu doped SPION/Bioactive glass nanoparticles had the highest osteoblast viability up to 7 days in vitro, while doping the samples with 2% zinc did not yield bone cell viability as high as the Eu doped ones. Importantly, Eu doped SPION/Bioactive glass nanoparticles inhibited gram-positive Staphylococcus aureus (S. aureus) and gram-negative Escherichia coli (E. coli) growth up to 48 h in vitro. The results showed that Eu doping of SPION/Bioactive glass nanoparticles increased osteoblast viability and inhibited bacterial growth, while possessing superparamagnetic properties and exhibiting red luminescence.

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