期刊
CERAMICS INTERNATIONAL
卷 49, 期 12, 页码 19851-19860出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2023.03.102
关键词
Magnetic hyperthermia; Iron oxides; Drug delivery; Gadolinium; Strontium
Despite commendable efforts in fighting cancer, it remains a significant global public health concern. In this study, we synthesized Sr2+ and Gd3+ doped magnetite nanoparticles for magnetic hyperthermia and drug delivery applications. Characterization revealed the formation of magnetite nanoparticles with a size of 10 nm and spherical shapes of approximately 12 nm. The Fe3O4@Gd nanoparticles showed a higher BET-specific surface area than Fe3O4@Sr nanoparticles. The heat generation in an alternating magnetic field was slower in Fe3O4@Sr@CA@5-flu compared to Fe3O4@Gd@CA@5-flu.
Commendable efforts have been gingered towards the fight against cancer. Nevertheless, it remains a major public health concern due to its predominant cause of death globally. Given this, we synthesized two different nanoparticles, Sr2+ and Gd3+ doped magnetite for magnetic hyperthermia and drug delivery application. Based on the characterization, the diffractogram shows that only one phase related to magnetite with a crystallite size of 10 nm was formed. TEM images revealed nanoparticles of spherical shapes of approximately 12 nm. There is no difference in magnetic saturation of the as-received synthesized samples (Fe3O4@Sr and Fe3O4@Gd), while the BET-specific surface area of Fe3O4@Gd is 8 m2 g-1 higher than Fe3O4@Sr. The heat generation in alternating magnetic field (the magnetic hyperthermia) of Fe3O4@Sr functionalized with citric acid and loaded with 5-fluorouracil (Fe3O4@Sr@CA@5-flu) is slower than Fe3O4@Gd@CA@5-flu. The specific absorption rate (SAR) of Fe3O4@Gd@CA@5-flu, 112.0 +/- 10.4 W g-1 was found to be higher than that of Fe3O4@Sr@CA@5-flu. The thermogram shows that 11% of the drug was successfully loaded on Fe3O4@Gd@CA@5-flu. The release of the antitumor drug by the synthesized nanoparticle drug carriers for ovarian cancer (SKOV-3 cells) therapy showed that more than 50% of the cancer cell's viability was reduced after 72 h of incubation. The synthesized nano-particles demonstrated a promising drug carrier for the treatment of SKOV-3 cells.
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