期刊
CELLULAR SIGNALLING
卷 104, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2023.110588
关键词
ROR1; WNT5A; cancer; Tyrosine kinase; AKT; MAPK; NF-?B; STAT3
类别
ROR1 is a receptor for WNT5A and related Wnt proteins, which regulates cell migration, cell polarity, neural patterning, and organogenesis during embryonic development. It transduces signals from Wnt glycoproteins to intracellular Wnt/PCP and Wnt/Ca++ pathways. In addition, it activates multiple signaling pathways in cancer cells, such as PI3K/AKT, MAPK, NF-Kappa B, STAT3, and Hippo pathways. Aberrant expression of ROR1 in cancer is associated with tumor progression and poor survival, making it a potential therapeutic target.
The receptor tyrosine kinase orphan receptor 1 (ROR1) is a receptor for WNT5A and related Wnt proteins, that play an important role during embryonic development by regulating cell migration, cell polarity, neural patterning, and organogenesis. ROR1 exerts these functions by transducing signals from the Wnt secreted gly-coproteins to the intracellular Wnt/PCP and Wnt/Ca++ pathways. Investigations in adult human cells, particu-larly cancer cells, have demonstrated that besides these two pathways, the WNT5A/ROR1 axis can activate a number of signaling pathways, including the PI3K/AKT, MAPK, NF-Kappa B, STAT3, and Hippo pathways. Moreover, ROR1 is aberrantly expressed in cancer and was associated with tumor progression and poor survival by pro-moting cell proliferation, survival, invasion, epithelial to mesenchymal transition, and metastasis. Consequently, numerous therapeutic tools to target ROR1 are currently being evaluated in cancer patients. In this review, we will provide a detailed description of the signaling pathways regulated by ROR1 in cancer and their impact in tumor progression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据