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Advanced Overview of Biomarkers and Techniques for Early Diagnosis of Alzheimer's Disease

CELLULAR AND MOLECULAR NEUROBIOLOGY (2023)

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Review Pharmacology & Pharmacy

Highlighting the Potential Role of Exosomes as the Targeted Nanotherapeutic Carrier in Metastatic Breast Cancer

Alisha Khera et al.

Summary: Breast cancer, the second most common type of cancer, is a major cause of death among women. Exosomes, a type of extracellular vesicle, play a crucial role in the transportation of biomolecules throughout the body and can be easily detected due to specific biomarkers. They not only contribute to the progression of various diseases, but also play a role in tumor progression and metastasis in breast cancer. Exosomes and related engineering strategies are being explored as nano-carriers for drug delivery in breast cancer. This review discusses the role of exosomes in breast cancer and the development of engineering strategies to enhance their efficiency as drug delivery systems.

CURRENT DRUG DELIVERY (2023)

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Review Neurosciences

Role of Tau in Various Tauopathies, Treatment Approaches, and Emerging Role of Nanotechnology in Neurodegenerative Disorders

Preetpal Kaur et al.

Summary: Several protein kinases and phosphatases regulate tau protein phosphorylation, and an imbalance in their activity leads to tau hyper-phosphorylation. Aberrant tau phosphorylation causes it to dissociate from microtubules and form neurofibrillary tangles, contributing to neurodegenerative disorders. Restorative approaches targeting hyperphosphorylated tau protein are being explored, and drug delivery systems based on nanocarriers provide a potential solution for the limited transport of drugs to the central nervous system. This review discusses tau protein, regulation of its phosphorylation, drugs in use or under clinical trials, and treatment strategies for tauopathies based on the role of tau hyperphosphorylation in disease pathogenesis.

MOLECULAR NEUROBIOLOGY (2023)

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Article Clinical Neurology

Associating Alzheimer's disease pathology with its cerebrospinal fluid biomarkers

Claire Bridel et al.

Summary: This study examines the relationship between neuropathology and CSF biomarkers in Alzheimer's disease patients, finding that the associations are stronger and more significant with longer intervals between lumbar puncture and death. This suggests that CSF biomarkers may not be well suited for monitoring neuropathological changes at later disease stages.

BRAIN (2022)

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Review Oncology

Emerging role of exosomes as biomarkers in cancer treatment and diagnosis

Niloofar Asadi Hanjani et al.

Summary: Cancer is a leading cause of death worldwide, with rapidly growing incidence and mortality rates. The current methods used for cancer diagnosis and treatment are invasive and cost-effective. Recent research has revealed the effective roles of exosomes as promising biomarkers for diagnosis, prognosis, and prediction. Exosomes, which are membrane-bound extracellular vesicles containing genetic material and proteins, can detect various types of cancers at early stages with high sensitivity and specificity, and can also efficiently deliver therapeutic drugs.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2022)

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Editorial Material Pharmacology & Pharmacy

Blood-Based Alzheimer's Biomarkers

[Anonymous]

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

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Review Clinical Neurology

Advances in Proteomic and Metabolomic Profiling of Neurodegenerative Diseases

Artur Schumacher-Schuh et al.

Summary: Proteomics and metabolomics are promising fields for studying the molecular mechanisms of neurodegenerative diseases. This review provides an overview of the current status of proteomic and metabolomic profiling in neurodegenerative diseases, with a focus on Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The potential of these approaches for biomarker discovery and therapeutic development is discussed, along with the challenges and limitations in the field.

FRONTIERS IN NEUROLOGY (2022)

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Article Genetics & Heredity

New insights into the genetic etiology of Alzheimer's disease and related dementias

Celine Bellenguez et al.

Summary: By characterizing the genetic landscape of Alzheimer's disease and related dementias, new loci have been identified and a new genetic risk score associated with the risk of future Alzheimer's disease and dementia has been generated.

NATURE GENETICS (2022)

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Review Neurosciences

Translational approaches to understanding resilience to Alzheimer's disease

Sarah M. Neuner et al.

Summary: This review explores the insights gained from both human and animal studies regarding resilience in Alzheimer's disease, and highlights future approaches to translating these insights into therapeutics.

TRENDS IN NEUROSCIENCES (2022)

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Article Geriatrics & Gerontology

Multi-Modal Neuroimaging Neural Network-Based Feature Detection for Diagnosis of Alzheimer's Disease

Xianglian Meng et al.

Summary: This study proposes a novel multi-modal LassoNet framework that effectively distinguishes Alzheimer's disease from healthy control. It shows superior classification performance, generalization, and reproducibility. The study also identifies discriminative brain regions, providing important insights into the mechanisms underlying Alzheimer's disease development.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Review Neurosciences

Blood-brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders

Hema Kumari Alajangi et al.

Summary: The integrity of the blood-brain barrier (BBB) is crucial for the normal functioning of the central nervous system (CNS). Nanotechnology-based approaches are being explored as alternatives to conventional methods for treating neurological diseases caused by BBB disruption. It is important to understand the characteristics of BBB for the discovery of new drugs that can effectively cross the barrier. This article discusses the building blocks of BBB, immune response activation upon breach of the barrier, autoimmune neurological disorders caused by BBB dysfunction, mechanisms of transport pathways across BBB, and novel strategies and alternative routes for drug delivery into CNS.

MOLECULAR BRAIN (2022)

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Article

Alzheimer’s disease detection from optimal EEG channels and Tunable Q-Wavelet Transform

Digambar Vithhalbuwa Puri et al.

Indonesian Journal of Electrical Engineering and Computer Science (2022)

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Review Clinical Neurology

Blood-based biomarkers for Alzheimer's disease: towards clinical implementation

Charlotte E. Teunissen et al.

Summary: Recent research suggests that blood-based biomarkers for Alzheimer's disease may become a reality, with consistent results across different cohorts. Additionally, other blood-based biomarkers can provide information about disease progression and treatment effects.

LANCET NEUROLOGY (2022)

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Review Neurosciences

The β-Secretase BACE1 in Alzheimer's Disease

Harald Hampel et al.

Summary: BACE1 is a well-validated therapeutic target for slowing down Aβ production in early AD, despite previous clinical trials being discontinued. Further research should focus on the roles of BACE1 and Aβ in physiological and pathophysiological processes, as well as the substrates and downstream effects of BACE1 and BACE2.

BIOLOGICAL PSYCHIATRY (2021)

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Article Clinical Neurology

Blood neuro-exosomal synaptic proteins predict Alzheimer's disease at the asymptomatic stage

Longfei Jia et al.

Summary: This study showed that exosomal GAP43, neurogranin, SNAP25, and synaptotagmin 1 serve as effective biomarkers for predicting AD 5 to 7 years before cognitive impairment.

ALZHEIMERS & DEMENTIA (2021)

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Article Biochemistry & Molecular Biology

Interrelations of Alzheimer′s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation

Frederic Brosseron et al.

Summary: Studies have shown a close correlation between a set of inflammatory markers and levels of tau or neurofilament, suggesting an inflammatory response to neuronal damage. These markers could be important in diagnosing AD.

JOURNAL OF NEUROCHEMISTRY (2021)

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Review Cell Biology

The prognostic utility of CSF neurogranin in predicting future cognitive decline in the Alzheimer's disease continuum: A systematic review and meta-analysis with narrative synthesis

Si Qi Yoong et al.

Summary: CSF Ng shows promising potential in predicting cognitive decline, especially in predicting MMSE decline in A beta+ mild cognitive impairment with high-quality evidence. It also has the ability to predict the decline of memory and executive function in mild cognitive impairment. The combination of CSF Ng and A beta 42 may also be a predictor of cognitive decline. More studies are needed to validate its use as an AD prognostic marker.

AGEING RESEARCH REVIEWS (2021)

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Article Clinical Neurology

Head-to-head comparison of clinical performance of CSF phospho-tau T181 and T217 biomarkers for Alzheimer's disease diagnosis

Thomas K. Karikari et al.

Summary: Phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) is a biomarker for Alzheimer's disease (AD), and novel immunoassays targeting different fragments of p-tau provide better diagnostic accuracy for MCI-AD and AD dementia, especially in relation to A beta pathophysiology.

ALZHEIMERS & DEMENTIA (2021)

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Review Biochemistry & Molecular Biology

The Evolving Landscape of Exosomes in Neurodegenerative Diseases: Exosomes Characteristics and a Promising Role in Early Diagnosis

Simran Rastogi et al.

Summary: Exosomes, small extracellular vesicles of 30-150 nm in diameter, have recently been found to play a role in the initiation and progression of neurodegenerative diseases. They carry specific proteins, lipids, functional mRNAs, and various non-coding RNAs, making them potential diagnostic biomarkers for early disease detection. Their composition and function vary depending on their originating and recipient cells, and they have been highlighted as a novel field for early diagnosis in neurodegenerative diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

The Aβ(1-38) peptide is a negative regulator of the Aβ(1-42) peptide implicated in Alzheimer disease progression

Maa O. Quartey et al.

Summary: The study suggests that Aβ(1-38) interacts differently with Aβ(1-40) and Aβ(1-42), with the potential to counteract the negative effects of Aβ(1-42) on neurons and alleviate related phenotypes.

SCIENTIFIC REPORTS (2021)

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Article Psychiatry

Serum d-serine levels are altered in early phases of Alzheimer's disease: towards a precocious biomarker

Luciano Piubelli et al.

Summary: This study investigated the levels of d-amino acids in the serum of Alzheimer's disease (AD) patients and healthy subjects, and found that the serum d-serine level and d-/total serine ratio can serve as novel biomarkers for the progression of AD.

TRANSLATIONAL PSYCHIATRY (2021)

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Article Psychiatry

Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer's disease

Pratishtha Chatterjee et al.

Summary: The study found that plasma GFAP levels are elevated in cognitively normal older adults at risk of AD, indicating that astrocytic damage or activation may start from the pre-symptomatic stage of the disease and is associated with brain Aβ load. The potential of plasma GFAP to contribute to a diagnostic blood biomarker panel, along with plasma Aβ 1-42/Aβ 1-40 ratios, for cognitively normal older adults at risk of AD was highlighted by the observations from the present study.

TRANSLATIONAL PSYCHIATRY (2021)

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Review Clinical Neurology

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

Carolina Alquezar et al.

Summary: Post-translational modifications play a crucial role in regulating tau protein function, including phosphorylation and acetylation. While these modifications may regulate protein function under normal conditions, they can be hijacked in disease states. Limited understanding exists on how these modifications impact tau protein, but studies indicate their critical role in localization, interactions, and other aspects.

FRONTIERS IN NEUROLOGY (2021)

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Article Clinical Neurology

Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease

Salvatore Spina et al.

Summary: Co-pathologies are important in the expression of the clinical phenotype of Alzheimer's disease, with differences in neuropathological diagnoses between early-onset and late-onset patients. Late-onset Alzheimer's disease is more likely to have LATE, hippocampal sclerosis, argyrophilic grain disease, and vascular brain injury.Sex does not significantly impact the number of co-pathologies present.

BRAIN (2021)

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Review Neurosciences

A Review of Automated Techniques for Assisting the Early Detection of Alzheimer's Disease with a Focus on EEG

Eduardo Perez-Valero et al.

Summary: This paper reviews state-of-the-art approaches using signal processing and machine learning to automate the detection of Alzheimer's disease and its prodromal stages, focusing on EEG as a suitable alternative for early detection and summarizing the current research on automatic detection.

JOURNAL OF ALZHEIMERS DISEASE (2021)

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Review Clinical Neurology

Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research

Christina M. Moloney et al.

Summary: Neurofibrillary tangles, a hallmark of Alzheimer's disease, undergo a dynamic process of maturity that impacts neuron biology and cognitive function. The levels of maturity include pretangles, mature tangles, and ghost tangles, with distinct characteristics observed through tau protein immunostaining and morphologic changes. Post-translational modifications of tau play a significant role in therapeutic targeting strategies for cognitive dysfunction.

ALZHEIMERS & DEMENTIA (2021)

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Review Clinical Neurology

Brain SPECT as a Biomarker of Neurodegeneration in Dementia in the Era of Molecular Imaging: Still a Valid Option?

Rodolfo Ferrando et al.

Summary: Biomarkers play a crucial role in the diagnosis and research of dementia, with neurodegeneration biomarkers being key in identifying patterns of brain involvement. PET and SPECT technologies are effective in revealing functional alterations underlying neurodegenerative diseases.

FRONTIERS IN NEUROLOGY (2021)

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Article Medicine, General & Internal

Alzheimer disease

David S. Knopman et al.

Summary: Alzheimer's disease is a neurodegenerative disorder characterized by cognitive impairments. The pathophysiology involves a complex interplay of loss of synaptic homeostasis and dysfunction in endosomal/lysosomal clearance pathways. Therapeutic options are still being sought to substantially alter the clinical course of individuals with Alzheimer's disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Neurosciences

The role of vascular dementia associated genes in patients with Alzheimer's disease: A large case-control study in the Chinese population

Xuewen Xiao et al.

Summary: Common variants in COL4A1 and rare variants in HTRA1, NOTCH3, COL4A1, and CST3 may be implicated in AD pathogenesis in the Chinese population. Additionally, GSN, ITM2B, and COL4A1 are probably involved in the development of AD endophenotypes.

CNS NEUROSCIENCE & THERAPEUTICS (2021)

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Article Biochemistry & Molecular Biology

Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity

Maria Berrocal et al.

Summary: The study focuses on sorcin as a potential regulator of PMCA and an antagonist of A beta and tau toxicity. Results demonstrate that sorcin acts as an activator of PMCA, counteracting the inhibitory effects of A beta and tau on the pump, and interacting with them to neutralize their neurotoxicity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Clinical Neurology

Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group

Bruno Dubois et al.

Summary: The use of biomarkers in the diagnosis of Alzheimer's disease has limitations and should be used cautiously in a clinical setting, restricted to individuals with specific phenotypes and positive biomarkers. Biomarker-positive cognitively unimpaired individuals should be considered at-risk for progression to Alzheimer's disease.

LANCET NEUROLOGY (2021)

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Review Neurosciences

Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery

Bing Bai et al.

Summary: Mass spectrometry-based proteomics plays a crucial role in Alzheimer's disease research, allowing for in-depth analysis of proteome and protein post-translational modifications. Studies have revealed not only known amyloid and tau pathways, but also novel protein networks in AD. Meta-analysis of deep datasets has identified a large number of differentially expressed proteins in the AD brain proteome, indicating the involvement of diverse cell types in Alzheimer's pathology.

MOLECULAR NEURODEGENERATION (2021)

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Review Biochemistry & Molecular Biology

Biomarkers for neurodegenerative diseases

Oskar Hansson

Summary: Biomarkers for neurodegenerative diseases play a crucial role in improving diagnostic workup and therapy monitoring, with emerging blood-based markers and discussions on their implementation in clinical practice and trials.

NATURE MEDICINE (2021)

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Review Clinical Neurology

Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus

Brianne M. Bettcher et al.

Summary: The dysregulation of central and peripheral immune responses in Alzheimer's disease has raised questions about the communication between these systems and its potential as a therapeutic target. While evidence suggests the importance of peripheral-central immune crosstalk in AD, further research is needed to understand the mechanisms and implications for therapeutic interventions. This roadmap provides a comprehensive overview of the current status of research in this area and outlines a research prospectus for future interdisciplinary studies.

NATURE REVIEWS NEUROLOGY (2021)

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Article Clinical Neurology

Developing the ATX(N) classification for use across the Alzheimer disease continuum

Harald Hampel et al.

Summary: Breakthroughs in highly accurate fluid and neuroimaging biomarkers have transformed the conceptual approach to Alzheimer's disease from symptom-based to a clinical-biological construct. The AT(N) and evolving ATX(N) systems play crucial roles in categorizing individuals and potential applications in clinical trials and future practice. Current challenges include validation, standardization, and real-world application of these systems.

NATURE REVIEWS NEUROLOGY (2021)

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Article Multidisciplinary Sciences

Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease

William T. Hu et al.

Summary: Neuroinflammation is observed in Alzheimer's disease. Here the authors show that 15 proteins related to inflammation found in CSF can potentially be used as a prognostic biomarker, providing predictive information independent of established Alzheimer's markers.

NATURE COMMUNICATIONS (2021)

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Article Clinical Neurology

Head-to-Head Comparison of 8 Plasma Amyloid-beta 42/40 Assays in Alzheimer Disease

Shorena Janelidze et al.

Summary: The study conducted in three different hospitals in Sweden from 2010 to 2014 found that certain mass spectrometry-based methods performed better for detecting brain A beta pathology compared to most immunoassays for plasma A beta 42/40 in patients with early Alzheimer's disease.

JAMA NEUROLOGY (2021)

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Article Biotechnology & Applied Microbiology

Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2

Harrison Specht et al.

Summary: The SCoPE2 technology was developed to improve the accuracy and throughput of single-cell proteomics through automated sample preparation, revealing the gradual differences in the proteome of macrophages during the enhancement of heterogeneity and allowing differentiation of cell states.

GENOME BIOLOGY (2021)

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Review Medical Laboratory Technology

Cerebrospinal fluid proteomics and biological heterogeneity in Alzheimer's disease: A literature review

Kirsten E. J. Wesenhagen et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2020)

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Correction Genetics & Heredity

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk (vol 51, 404, 2019)

Iris E. Jansen et al.

NATURE GENETICS (2020)

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Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders

M. M. J. van den Berg et al.

PROGRESS IN NEUROBIOLOGY (2020)

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Review Clinical Neurology

The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease

Marti Colom-Cadena et al.

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An update on fluid biomarkers for neurodegenerative diseases: recent success and challenges ahead

Joel Simren et al.

CURRENT OPINION IN NEUROBIOLOGY (2020)

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Proteomics and Neurodegenerative Disorders: Advancements in the Diagnostic Analysis

Nidhi Puranik et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2020)

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Review Biochemistry & Molecular Biology

New fluid biomarkers tracking non-amyloid-β and non-tau pathology in Alzheimer's disease

Sun Ah Park et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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SPR enhanced DNA biosensor for sensitive detection of donkey meat adulteration

Maryam Mansouri et al.

FOOD CHEMISTRY (2020)

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Applications of biosensors in Alzheimer's disease diagnosis

Lais Canniatti Brazaca et al.

TALANTA (2020)

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Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease

Shorena Janelidze et al.

NATURE COMMUNICATIONS (2020)

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Improving the resistance and resilience framework for aging and dementia studies

Eider M. Arenaza-Urquijo et al.

ALZHEIMERS RESEARCH & THERAPY (2020)

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Neurogranin as a cognitive biomarker in cerebrospinal fluid and blood exosomes for Alzheimer's disease and mild cognitive impairment

Weilin Liu et al.

TRANSLATIONAL PSYCHIATRY (2020)

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CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges

Simon Hornung et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

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Review Health Care Sciences & Services

Advantages and Pitfalls in Fluid Biomarkers for Diagnosis of Alzheimer's Disease

Syed Haris Omar et al.

JOURNAL OF PERSONALIZED MEDICINE (2020)

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Surface plasmon resonance biosensor for the detection of tau-amyloid β complex

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Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases

Ilaria Genovese et al.

CELL DEATH & DISEASE (2020)

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Article Medicine, General & Internal

Association between plasma exosome neurogranin and brain structure in patients with Alzheimer's disease: a protocol study

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BMJ OPEN (2020)

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Review Health Care Sciences & Services

Biomarkers for Alzheimer's Disease Early Diagnosis

Eva Auso et al.

JOURNAL OF PERSONALIZED MEDICINE (2020)

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Review Chemistry, Medicinal

Exosomal miRNAs as Potential Diagnostic Biomarkers in Alzheimer's Disease

Ida Manna et al.

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Article Multidisciplinary Sciences

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Niklas Mattsson-Carlgren et al.

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Article Clinical Neurology

Correlations of apathy with clinical symptoms of Alzheimer's disease and olfactory dysfunctions: a cross-sectional study

Shu-yang Yu et al.

BMC NEUROLOGY (2020)

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Article Biophysics

Surface plasmon resonance biosensors for detection of Alzheimer's biomarkers; an effective step in early and accurate diagnosis

Aysa Rezabakhsh et al.

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Article Computer Science, Software Engineering

LassoNet: Deep Lasso-Selection of 3D Point Clouds

Zhutian Chen et al.

IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

The role of brain structural magnetic resonance imaging in the assessment of hippocampal subfields in Alzheimer's disease

Sameh Hany Sobhy Saad et al.

EGYPTIAN JOURNAL OF RADIOLOGY AND NUCLEAR MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Peripheral inflammatory biomarkers in Alzheimer's disease: a brief review

Jong-Chan Park et al.

BMB REPORTS (2020)

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Review Medical Laboratory Technology

Biomarkers of Alzheimer Disease

Melissa M. Budelier et al.

JOURNAL OF APPLIED LABORATORY MEDICINE (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Amyloid burden identifies neuropsychological phenotypes at increased risk of progression to Alzheimer's disease in mild cognitive impairment patients

Andrea Ciarmiello et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2019)

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Review Chemistry, Medicinal

Involvement of calpain in the neuropathogenesis of Alzheimer's disease

Yacoubou Abdoul Razak Mahaman et al.

MEDICINAL RESEARCH REVIEWS (2019)

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Article Chemistry, Multidisciplinary

A Nanoplasmonic Biosensor for Ultrasensitive Detection of Alzheimer's Disease Biomarker Using a Chaotropic Agent

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ACS SENSORS (2019)

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Free radicals in Alzheimer's disease: Lipid peroxidation biomarkers

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CLINICA CHIMICA ACTA (2019)

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Article Medicine, General & Internal

CLINICAL AND BIOMEDICAL APPLICATIONS OF SURFACE PLASMON RESONANCE SYSTEMS

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REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION (2019)

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Advantages and disadvantages of the use of the CSF Amyloid (A) 42/40 ratio in the diagnosis of Alzheimer's Disease

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Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer's disease: protocol of the BEAT-IT study

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Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease

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Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease

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IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2019)

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An electrochemical peptide-based biosensor for the Alzheimer biomarker amyloid-β(1-42) using a microporous gold nanostructure

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A combined miRNA-piRNA signature to detect Alzheimer's disease

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Analysis of regularity in the EEG background activity of Alzheimer's disease patients with Approximate Entropy

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Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

A Petzold

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Early event-related potential changes during working memory activation predict rapid decline in mild cognitive impairment

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JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2005)

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Review Neurosciences

Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease

ZZ Chong et al.

PROGRESS IN NEUROBIOLOGY (2005)

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Review Environmental Sciences

Low dose mercury toxicity and human health

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Article Geriatrics & Gerontology

Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease

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ANNUAL REVIEW OF MEDICINE (2004)

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Functional brain imaging in the dementias: role in early detection, differential diagnosis, and longitudinal studies

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EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2002)

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Review Multidisciplinary Sciences

Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics

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SCIENCE (2002)

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Article Radiology, Nuclear Medicine & Medical Imaging

Serial brain MRI at 3-6 month intervals as a surrogate marker for Alzheimer's disease

KM Bradley et al.

BRITISH JOURNAL OF RADIOLOGY (2002)

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Highly conserved and disease-specific patterns of carboxyterminally truncated Aβ peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation

J Wiltfang et al.

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Article Neurosciences

Sign of lipid peroxidation as measured in the urine of patients with probable Alzheimer's disease

EE Tuppo et al.

BRAIN RESEARCH BULLETIN (2001)

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Role of phosphorylation in the conformation of τ peptides implicated in Alzheimer's disease

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BIOCHEMISTRY (2000)

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Magnetoencephalographic analysis of cortical activity in Alzheimer's disease: a pilot study

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CLINICAL NEUROPHYSIOLOGY (2000)

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