Chemical reprogramming takes the fast lane

Article Cell & Tissue Engineering

Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming

Shijia Liuyang et al.

Summary: We have developed a robust and chemically defined reprogramming protocol that significantly shortens the induction time for generating human pluripotent stem cells from somatic cells. This protocol promotes cell proliferation and metabolic activities, leading to a more direct reprogramming process.

CELL STEM CELL (2023)

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Article Multidisciplinary Sciences

Chemical reprogramming of human somatic cells to pluripotent stem cells

Jingyang Guan et al.

Summary: This study demonstrates the chemical reprogramming of human somatic cells to human chemically induced pluripotent stem cells, which exhibit key features of embryonic stem cells. The induction of an intermediate plastic state and inhibition of the JNK pathway are crucial for successful chemical reprogramming.

NATURE (2022)

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Review Cell Biology

Direct cell reprogramming: approaches, mechanisms and progress

Haofei Wang et al.

Summary: Direct reprogramming converts cells from one lineage into another without going through a pluripotent state, and it is a promising strategy for generating functional cells for therapeutic purposes. Recent advancements include using defined factors for lineage conversion, enhancing reprogrammed cell maturation, and addressing challenges in in vivo direct reprogramming for translational applications.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Multidisciplinary Sciences

Modelling human blastocysts by reprogramming fibroblasts into iBlastoids

Xiaodong Liu et al.

Summary: The study describes a method to reprogram fibroblasts into human blastocyst models, known as iBlastoids. This model can mimic the overall structure of blastocysts, including inner cell mass, epiblast, primitive endoderm-like cells, blastocoel-like cavity, and trophectoderm-like cells. The iBlastoids system is believed to facilitate the study of early human development, the effects of gene mutations and toxins during early embryogenesis, and the development of new therapies associated with in vitro fertilization.

NATURE (2021)

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Review Cell Biology