☆ 4.7 Review

Oxidative stress in intervertebral disc degeneration: Molecular mechanisms, pathogenesis and treatment

CELL PROLIFERATION (2023)

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Review Cell Biology

Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration

Hai-Wei Chen et al.

Summary: Intervertebral disc degeneration (IDD) is an important cause of chronic low back pain (LBP) and serves as the pathological basis for various spinal degenerative diseases. Factors such as autophagy, oxidative stress, inflammatory responses, ECM homeostasis, cellular senescence, and apoptosis are involved in reducing ECM synthesis by intervertebral disc (IVD) cells and accelerating IDD progression. The mTOR signaling pathway plays a crucial role in the regulation of autophagy, oxidative stress, inflammatory responses, ECM homeostasis, cellular senescence, and apoptosis in IVD cells.

CELL PROLIFERATION (2023)

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Article Cell Biology

Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress

Wen Yang et al.

Summary: In this study, the effects of HIF-1 alpha on mouse primary nucleus pulposus cells (MNPCs) exposed to TNF-alpha were observed, the potential mechanism was explored and a rabbit IVDD model was established to verify the protective role of HIF-1 alpha on IVDD.

INFLAMMATION (2023)

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Article Clinical Neurology

miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1

Jiafang Zhang et al.

Summary: This study investigated the role of differentially expressed miRNAs in the pathogenesis of intervertebral disk degeneration (IVDD). The results showed that miR-4478 was upregulated in IVDD patients' nucleus pulposus (NP) tissues. Silencing miR-4478 inhibited hydrogen peroxide (H2O2)-induced nucleus pulposus cells (NPCs) apoptosis. miR-4478 regulated H2O2-induced NPCs apoptosis by modulating MTH1. Furthermore, downregulation of miR-4478 alleviated IVDD symptoms in a mouse model.

SPINE (2023)

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Review Oncology

An update on vitamin D signaling and cancer

Carsten Carlberg et al.

Summary: A low vitamin D status is associated with an increased risk of various cancers. The biologically active form of vitamin D, 1,25(OH)2D3, influences the epigenome and transcriptome of healthy and neoplastic cells, affecting their growth and differentiation.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Cell Biology

Role of autophagy in intervertebral disc degeneration

Rebecca Kritschil et al.

Summary: Intervertebral disc degeneration (IDD) is a major cause of low back pain, and the lack of understanding regarding nucleus pulposus (NP) cell metabolism and physiology hinders the development of effective treatments. Autophagy is a potential mechanism for NP cells to survive in the harsh microenvironment of the intervertebral disc, but further research is needed to determine its exact regulation and potential as a therapeutic target for IDD. Studies confirm the presence of autophagy markers in IDD tissue, but more in-depth research is necessary to establish the role of autophagy in maintaining NP cell health.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Article Chemistry, Multidisciplinary

Prussian Blue Nanoparticles Stabilize SOD1 from Ubiquitination-Proteasome Degradation to Rescue Intervertebral Disc Degeneration

Tangjun Zhou et al.

Summary: The study found that Prussian blue nanoparticles (PBNPs) can alleviate intracellular oxidative stress and increase the activity of antioxidant enzymes, thus improving mitochondrial structure to enhance antioxidation ability and rescuing disc degeneration caused by oxidative stress in a rat model.

ADVANCED SCIENCE (2022)

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Article Cell Biology

Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells

Chenglong Xie et al.

Summary: This study explored the effects of apigenin on intervertebral disc degeneration (IVDD) and found that it has a protective role in NP cells. It was found that apigenin can inhibit apoptosis, senescence, and ECM degradation, and also restore the blockage of autophagic flux. Mechanistically, apigenin promotes the nuclear translocation of TFEB via the AMPK/mTOR signaling pathway to alleviate autophagy dysfunction.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Cell Biology

Manual therapy regulates oxidative stress in aging rat lumbar intervertebral discs through the SIRT1/FOXO1 pathway

Chongjie Yao et al.

Summary: This study demonstrates that manual therapy intervention may delay the lumbar intervertebral disc degeneration in aging rats, improving motor function and regulating markers of senescence. Additionally, manual therapy can reduce oxidative stress through the SIRT1/FOXO1 pathway, thereby delaying disc aging. This study highlights the importance of drug-free, non-invasive mechanical interventions in improving the physical function of the elderly.

AGING-US (2022)

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Review Surgery

Intervertebral Disc Degeneration Models for Pathophysiology and Regenerative Therapy -Benefits and Limitations

Yidian Wang et al.

Summary: The best IDD model should have the features of repeatability, measurability and controllability, and the selection of different animal models should be personalized based on research purposes. Organ culture models and animal models have their own advantages and disadvantages in studying IDD.

JOURNAL OF INVESTIGATIVE SURGERY (2022)

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Article Immunology

SIRT1 alleviates IL-1β induced nucleus pulposus cells pyroptosis via mitophagy in intervertebral disc degeneration

Zhaoxin Ma et al.

Summary: Inflammatory stress of nucleus pulposus cells (NPCs) plays an important role in the pathogenesis of intervertebral disc degeneration (IVDD). Pyroptosis and NLRP3 inflammasome activation have been reported aggravating IVDD. SIRT1, by promoting PINK1/Parkin mediated mitophagy, alleviates IL-1 beta induced NLRP3 inflammasome activation in NPCs, thus may be a potential therapeutic target for IVDD.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Oncology

Combination of BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma

Sara Badodi et al.

Summary: This study identifies the therapeutic potential of a combination treatment with BMI1 and MAPK/ERK inhibitors in BMI1(High);CHD7(Low) MB cells, and elucidates the role of the CHD7-BMI1-MAPK regulatory axis in the pathogenesis of MB.

NEURO-ONCOLOGY (2022)

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Article Cell Biology

Increased Expression of Prolyl Endopeptidase Induced by Oxidative Stress in Nucleus Pulposus Cells Aggravates Intervertebral Disc Degeneration

Huo-Liang Zheng et al.

Summary: This study found that the upregulation of PREP in degenerative intervertebral disc tissues and downregulation of PREP can maintain the viability of NP cells and attenuate intervertebral disc degeneration (IVDD). Tertbutyl hydroperoxide can inhibit the expression of PREP by activating the PI3K/AKT signaling pathway and reducing p53 expression.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Engineering, Biomedical

Intervertebral Disc Degeneration: Biomaterials and Tissue Engineering Strategies toward Precision Medicine

Isma Liza Mohd Isa et al.

Summary: This review examines the understanding of intervertebral disc pathology, the concept of precision medicine, and the rationale of personalized biomaterial-based tissue engineering to enhance disc regeneration and alleviate discogenic pain.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Cell Biology

MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis

Haiwei Ma et al.

Summary: This study revealed the expression changes of MFG-E8 in intervertebral disc degeneration (IVDD) and its role in regulating NP cells. MFG-E8 can inhibit the degenerative process and protect cells from damage, suggesting its potential therapeutic value for IVDD.

CELL DEATH DISCOVERY (2022)

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Article Engineering, Biomedical

Fucoidan-loaded nanofibrous scaffolds promote annulus fibrosus repair by ameliorating the inflammatory and oxidative microenvironments in degenerative intervertebral discs

Qifan Yu et al.

Summary: In this study, researchers developed a nanofibrous scaffold loaded with fucoidan, a natural marine polysaccharide with anti-inflammatory and antioxidative functions, to alleviate the adverse microenvironment of intervertebral disc degeneration (IDD). The results showed that the fucoidan-loaded scaffold significantly decreased the expression of genes and proteins related to inflammation and oxidative stress. Moreover, it reduced the degradation of extracellular matrix and promoted disc repair, indicating promising potential for IDD treatment.

ACTA BIOMATERIALIA (2022)

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Article Biochemistry & Molecular Biology

Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes

Wenchao Wang et al.

Summary: Iron overload is strongly associated with the onset and development of intervertebral disc degeneration (IVDD) through oxidative stress and ferroptosis.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Article Cell Biology

Metformin inactivates the cGAS-STING pathway through autophagy and suppresses senescence in nucleus pulposus cells

Chenghao Ren et al.

Summary: This study found that metformin inhibits senescence in nucleus pulposus cells by inactivating the cGAS-STING pathway through autophagy. The research also revealed that metformin reduces DNA damage during oxidative stress. These findings suggest a new application for metformin in cGAS-STING pathway-related diseases.

JOURNAL OF CELL SCIENCE (2022)

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Review Pharmacology & Pharmacy

Targeting Oxidative Stress and Inflammation in Intervertebral Disc Degeneration: Therapeutic Perspectives of Phytochemicals

Liang Kang et al.

Summary: Low back pain is a major cause of disability worldwide due to intervertebral disc degeneration (IDD). Current drug treatments for IDD primarily focus on symptoms rather than the underlying causes, but phytochemicals from plants offer potential protective effects with their anti-inflammatory and antioxidant properties against IDD.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Multidisciplinary Sciences

Advanced oxidation protein products induce annulus fibrosus cell senescence through a NOX4-dependent, MAPK-mediated pathway and accelerate intervertebral disc degeneration

Xiangheng Dai et al.

Summary: This study found that AOPPs induce senescence in AF cells through a NOX4-dependent and MAPK-mediated pathway, thereby accelerating IVDD.

PEERJ (2022)

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Review Immunology

Pathophysiology of RAGE in inflammatory diseases

Hanbing Dong et al.

Summary: The receptor for advanced glycation end products (RAGE) is a versatile receptor involved in various diseases, and targeting RAGE may be an effective strategy to block its signaling.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Endocrinology & Metabolism

Sirtuin Family and Diabetic Kidney Disease

Che Bian et al.

Summary: Diabetic kidney disease (DKD) is a common complication of diabetes, and the Sirtuin family plays an important role in its regulation through various mechanisms.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Cell Biology

Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular Interactions

Zhencong Li et al.

Summary: Through single-cell transcriptome sequencing analysis, specific cell lineages and gene expression changes during degeneration of the nucleus pulposus cells were identified, providing important clues for the study of intervertebral disc degeneration mechanisms.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated intervertebral disc degeneration in vivo

Zhao Zhang et al.

Summary: The translation of the paragraph: Although considered as a major contributor to low back pain (LBP), intervertebral disc degeneration (IVDD) has poor medical and surgical treatments. Various studies have revealed that endoplasmic reticulum (ER) stress and extracellular matrix (ECM) degeneration play a vital role in initiating and developing the progression of IVDD. Moreover, restoration of SIRT1/AMPK was confirmed to prevent IVDD and damage via maintaining ER and extracellular homeostasis. In addition, orientin (Ori) has been shown to upregulate SIRT1. However, the effect of Ori in nucleus pulposus cells (NPCs) is not determined. Hence, in this study we aim to explore the function of Ori in IVDD pathological model. The results demonstrate that Ori treatment in vitro increased SIRT1/AMPK in NPCs, maintained ECM and ER balance and decreased oxidative stress (OS) response. Ori rescued the disordered homeostasis stimulated by tert-butyl hydroperoxide (TBHP), and its function can be inhibited by thapsigargin (TG). Compound C and EX-527, inhibitors of AMPK and SIRT1 counteracted the Ori-mediated ER stress elimination. These results confirm that Ori exerts its effects by upregulating AMPK and SIRT1. Puncture-stimulated IVDD rats were used to show that Ori attenuates the pathological development in vivo. In all, we partly unveil the underlying mechanisms of Ori in IVDD.

APOPTOSIS (2022)

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Article Biochemistry & Molecular Biology

Telomere Shortening and Increased Oxidative Stress in Lumbar Disc Degeneration

Manassanan Jitjumnong et al.

Summary: This study found that patients with lumbar disc degeneration (LDD) had shorter telomeres, increased oxidative stress, and decreased antioxidant levels. The telomere length was negatively correlated with the severity of LDD, while oxidative stress markers (MDA and 8-OHdG) showed positive correlations with severity. These findings suggest that telomere length, as well as MDA and 8-OHdG levels, may be potential non-invasive biomarkers for assessing the severity of LDD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biotechnology & Applied Microbiology

Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy

Linjun Yang et al.

Summary: In this study, an injectable hydrogel with antibacterial, antioxidation, rapid gelation, and self-healing characteristics was developed for the treatment of intervertebral disc degeneration (IVDD). The hydrogel showed the ability to alleviate oxidative stress trauma and demonstrated promising therapeutic effects in a rat IVDD model. The combination of smart hydrogels and nanotechnology-mediated antioxidant therapy could serve as a novel treatment strategy for IVDD and other oxidative stress-related diseases.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Pharmacology & Pharmacy

Optineurin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

Zhilei Hu et al.

Summary: OPTN plays a positive role in alleviating H2O2-induced nucleus pulposus cell senescence and matrix degradation by promoting mitophagy to scavenge damaged mitochondria and excess reactive oxygen species, thereby slowing the progression of intervertebral disc degeneration.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway

Yuandong Shao et al.

Summary: This study demonstrated that icariin (ICA) effectively inhibited apoptosis in chondrocytes, increased extracellular matrix production, and promoted mitophagy while inhibiting ferroptosis. The protective effect of ICA on cartilage endplate (CEP) was mediated through the activation of the Nrf-2/HO-1 pathway. These findings suggest that ICA may be a potential medicine for the prevention and treatment of intervertebral disc degeneration (IVDD).

FRONTIERS IN PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights

Qian Xiang et al.

Summary: Intervertebral disc degeneration (IDD) is a common cause of lower back pain, and the molecular mechanisms underlying IDD are unclear, limiting treatment options. Oxidative stress is implicated in IDD, and the regulatory protein nuclear factor E2-related factor 2 (Nrf2) has been found to play a role in regulating IDD progression. Boosting Nrf2 activity through non-coding RNA therapies may be a valuable approach to alleviate oxidative stress in intervertebral disc cells.

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Lipid Peroxidation in Atherosclerotic Cardiovascular Diseases

Erica Gianazza et al.

Summary: Atherosclerotic cardiovascular diseases (ACVDs) are a major cause of death worldwide, especially in economically underdeveloped countries. Oxidative stress, particularly lipid peroxidation, plays a significant role in ACVDs and their development.

ANTIOXIDANTS & REDOX SIGNALING (2021)

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Review Cell Biology

Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

Yi Yu et al.

Summary: Ferroptosis is a newly identified iron-dependent cell death mechanism that differs from other cell death pathways, characterized by lipid peroxidation and accumulation of redox-active iron. Studies suggest that ferroptosis plays a crucial role in various cardiovascular diseases, and targeting ferroptosis may present a novel therapeutic approach in treating these conditions.

CELL DEATH DISCOVERY (2021)

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Article Cell Biology

Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis

Run-Ze Yang et al.

Summary: The study demonstrates the involvement of ferroptosis in the pathogenesis of intervertebral disc degeneration (IVDD) by detecting changes in protein levels and lipid peroxidation during oxidative stress. Treatment with ferroptosis inhibitors and ferritinophagy supports the role of ferroptosis in IVDD.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Review Cell Biology

Ferroptosis: molecular mechanisms and health implications

Daolin Tang et al.

Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.

CELL RESEARCH (2021)

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Article Medicine, Research & Experimental

MAPK/ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration

Hai-Jun Zhang et al.

Summary: Intervertebral disc degeneration (IDD) is a chronic skeletal muscle degenerative disease that is considered the main cause of low back pain. It is mainly caused by aging, trauma, genetic susceptibility, and other factors. Current treatment focuses on alleviating symptoms rather than targeting pathological changes in the intervertebral discs.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Chemistry, Medicinal

Neuroprotective mechanisms of mangiferin in neurodegenerative diseases

Tingjun Liu et al.

Summary: This review summarizes the latest research on the neuroprotective effects of Mangiferin (MGF) and its diverse molecular mechanisms in central nervous system (CNS) disorders.

DRUG DEVELOPMENT RESEARCH (2021)

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Article Cell Biology

Tea Polyphenol Attenuates Oxidative Stress-Induced Degeneration of Intervertebral Discs by Regulating the Keap1/Nrf2/ARE Pathway

Dawei Song et al.

Summary: This study demonstrated that tea polyphenols can protect nucleus pulposus cells and delay their degeneration by activating the Keap1/Nrf2/ARE pathway.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Cell & Tissue Engineering

Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy

Liwen Luo et al.

Summary: The study revealed the therapeutic effects of exosomes on intervertebral disc degeneration (IVDD), showing that they inhibit nucleus pulposus cell (NPC) apoptosis and activate the AKT and autophagy pathways to delay the progression of IVDD.

STEM CELLS (2021)

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Review Oncology

The KEAP1-NRF2 System as a Molecular Target of Cancer Treatment

Keiko Taguchi et al.

Summary: The KEAP1-NRF2 system attracts extensive interest in cancer research due to NRF2's dual activity as an oncogene and tumor suppressor. NRF2-addicted cancers exhibit high NRF2 expression and somatic mutations stabilize and accumulate NRF2. These cancers hijack NRF2's cytoprotective roles to survive in harsh microenvironments.

CANCERS (2021)

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Article Biochemistry & Molecular Biology

Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart

Diana Bou-Teen et al.

Summary: Excessive mitochondrial ROS production is linked to aging-related heart pathologies, but also serves as a fundamental function in orchestrating signaling pathways that have cardioprotective effects. Mitochondria in cardiac myocytes are abundant and specialized in subcellular populations, with interactions with other organelles influencing their function.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Cell Biology

SIRT3 mitigates intervertebral disc degeneration by delaying oxidative stress-induced senescence of nucleus pulposus cells

Jiayi Lin et al.

Summary: The study showed that SIRT3 can delay NPC senescence, reducing oxidative stress and mitigating intervertebral disc degeneration. The activation of the AMPK/PGC-1 alpha pathway partially regulates the effects of SIRT3, indicating a potential therapeutic target for IVDD.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Review Medicine, Research & Experimental

Estrogens as regulator of hematopoietic stem cell, immune cells and bone biology

Rupali Sani Kumar et al.

Summary: Hematopoietic stem cells provide a continuous supply of all immune cells through proliferation and differentiation decisions, with these decisions being controlled by the local bone marrow environment and long-range signals. Female longevity seems to depend on the major female sex hormone, estrogen, under homeostasis and disease conditions. Estrogen has effects on HSC, immune cells, and bone biology, with Estradiol (E2) being extensively investigated while the effects of other estrogens such as E1, E3, and E4 are starting to be understood. The clinical effects of estrogen as hormone therapy on HSC and immune cells are also discussed.

LIFE SCIENCES (2021)

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Review Chemistry, Analytical

Nanostructured material-based electrochemical sensing of oxidative DNA damage biomarkers 8-oxoguanine and 8-oxodeoxyguanosine: a comprehensive review

Ana-Maria Chiorcea-Paquim et al.

Summary: Oxidative DNA damage is crucial in the pathogenesis of various diseases, with 8-oxoG and 8-oxodG being important biomarkers for predicting oxidative stress levels. Electrochemical sensors based on modified electrodes are gaining interest due to their high sensitivity, selectivity, low-cost, and easy miniaturization and automation for detecting and quantifying these biomarkers in complex samples.

MICROCHIMICA ACTA (2021)

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Review Oncology

The potential role and trend of HIF-1α in intervertebral disc degeneration: Friend or foe?

Yongjin Li et al.

Summary: The study reveals the connection between lower back pain and intervertebral disc degeneration (IDD), with HIF-1α identified as a key factor in IDD treatment. Analyzing the pathological mechanisms of IDD, the trend of IDD development is predicted, and an early precautionary diagnosis and treatment method is proposed.

MOLECULAR MEDICINE REPORTS (2021)

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Review Orthopedics

Roles of NLRP3 inflammasome in intervertebral disc degeneration

G. Chao-yang et al.

Summary: This article summarizes the role of the NLRP3 inflammasome in the pathogenesis of IVDD and its application in treatment.

OSTEOARTHRITIS AND CARTILAGE (2021)

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Article Cell Biology

Long Noncoding RNA ANPODRT Overexpression Protects Nucleus Pulposus Cells from Oxidative Stress and Apoptosis by Activating Keap1-Nrf2 Signaling

Liang Kang et al.

Summary: ANPODRT can protect NP cells from oxidative stress and apoptosis by activating the Nrf2 signaling pathway. This study suggests that ANPODRT may be a potential therapeutic target for IDD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Cell Biology

Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo

Saideng Lu et al.

Summary: This study demonstrates the important roles of ferroptosis and FPN dysfunction in the pathogenesis of IVDD, revealing the regulatory mechanism of MTF1 nuclear translocation and validating the therapeutic potential of hinokitiol in the treatment of IVDD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Cell Biology

Salvianolic Acid B Protects Intervertebral Discs from Oxidative Stress-Induced Degeneration via Activation of the JAK2/STAT3 Signaling Pathway

Shouqian Dai et al.

Summary: The results suggest that salvianolic acid B (SAB) protects intervertebral discs from oxidative stress-induced degeneration by activating the JAK2/STAT3 signaling pathway, which enhances proliferation and attenuates apoptosis. In vitro experiments show that SAB can reverse oxidative stress induced by H2O2, reduce cell apoptosis, and restore cell proliferation.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Physiology

REGULATION AND METABOLIC FUNCTIONS OF mTORC1 AND mTORC2

Angelia Szwed et al.

Summary: Cells metabolize nutrients for growth and proliferation, with mTOR playing a key role in integrating growth and metabolism through the protein complexes mTORC1 and mTORC2. Study of mTORC1 and mTORC2 has expanded our understanding of cellular metabolism regulation and functions.

PHYSIOLOGICAL REVIEWS (2021)

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Article Clinical Neurology

Targeting oxidative stress with amobarbital to prevent intervertebral disc degeneration: Part I. in vitro and ex vivo studies

Dongrim Seol et al.

Summary: The study demonstrated that Amo was slightly more protective than NAC, both agents improved mitochondrial function, reduced tBHP-induced apoptosis, necrosis, and ROS production, and significantly suppressed the activation of MAPKs by tBHP.

SPINE JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Lipid peroxidation derived reactive carbonyl species in free and conjugated forms as an index of lipid peroxidation: limits and perspectives

Alessandra Altomare et al.

Summary: The interest in protein carbonylation has grown because protein adducts are recognized as being involved in the damaging action of oxidative stress. With the latest analytical methods, a deeper understanding of the molecular mechanisms of oxidative stress can be gained.

REDOX BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Protein oxidation-Formation mechanisms, detection and relevance as biomarkers in human diseases

Richard Kehm et al.

Summary: Generation of reactive oxygen species and related oxidants during life processes can lead to irreversible modifications of proteins, potentially contributing to pathological conditions and diseases.

REDOX BIOLOGY (2021)

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Review Nutrition & Dietetics

Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin

Clayton Vasey et al.

Summary: Melatonin plays a crucial role in regulating sleep and circadian rhythms, with dysregulation potentially leading to various disorders. However, there is still a lack of extensive clinical research on the therapeutic use of melatonin in the past 5 years.

NUTRIENTS (2021)

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Review Pharmacology & Pharmacy

Sirtuin Modulators in Cellular and Animal Models of Human Diseases

Jun Young Hong et al.

Summary: Sirtuins utilize NAD(+) to regulate cellular functions, are implicated in various human diseases, and thus the development of sirtuin modulators is of significant importance.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

AGE/RAGE in diabetic kidney disease and ageing kidney

Xia-Qing Wu et al.

Summary: Diabetic kidney disease is a major cause of chronic kidney disease, and controlling blood glucose is effective in preventing it. However, the formation of AGEs related to high glucose plays a central role in the pathogenesis of DKD, causing oxidative stress and inflammation.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Cell Biology

Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation via the NF-κB Pathway

Fudong Li et al.

Summary: Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP), with oxidative stress and inflammation-induced senescence and apoptosis of nucleus pulposus cells (NPCs) being the main cellular processes. ARG2 deficiency may prevent IDD by inhibiting the dyshomeostasis of the extracellular matrix (ECM), and the oxidative stress and inflammatory response-induced senescence and apoptosis via NF-kappa B.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

AMPK as a Potential Therapeutic Target for Intervertebral Disc Degeneration

Zhen Wang et al.

Summary: Intervertebral disc degeneration (IDD) is a major cause of low back pain, leading to characteristic pathological changes. Abnormal activity of AMP-activated protein kinase (AMPK) in degenerative disc cells is associated with IDD and regulates crucial biological behaviors in IDD. Therapies targeting AMPK for alleviating IDD are analyzed for potential therapeutic use.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Orthopedics

Targeting STING attenuates ROS induced intervertebral disc degeneration

Q. Guo et al.

Summary: STING upregulation in degenerated NP tissues promotes ECM degradation, apoptosis, and senescence, contributing to IVDD progression. Mechanistically, STING activates IRF3 pathway to exert its effects on IVDD development.

OSTEOARTHRITIS AND CARTILAGE (2021)

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Article Cell Biology

Ulinastatin Ameliorates IL-1β-Induced Cell Dysfunction in Human Nucleus Pulposus Cells via Nrf2/NF-κB Pathway

Xi Luo et al.

Summary: UTI improves NP cell viability and promotes proliferation, protects NP cells through mitigating IL-1 beta-induced apoptosis, inflammatory response, oxidative stress, and ECM degradation. The protective effect is achieved by activating the Nrf2/HO-1 signaling pathway and suppressing NF-kappa B signaling pathway. UTI may be a promising therapeutic medicine for IDD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Biochemistry & Molecular Biology

Morin attenuates pyroptosis of nucleus pulposus cells and ameliorates intervertebral disc degeneration via inhibition of the TXNIP/NLRP3/Caspase-1/IL-1β signaling pathway

Yifan Zhou et al.

Summary: The study revealed that TXNIP promotes pyroptosis in NP cells via the NLRP3/Caspase-1/IL-10 signaling pathway, while Morin shows significant inhibitory effects on the TXNIP/NLRP3/Caspase-1 signaling pathway, potentially serving as an effective therapeutic agent for IDD.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Review Cell Biology

NF-κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration

Guang-Zhi Zhang et al.

Summary: NF-κB is considered a pathogenic factor of intervertebral disc degeneration (IDD), studying its role and regulatory mechanism in IDD pathology can help in developing targeted therapeutic strategies to reduce potential risks.

CELL PROLIFERATION (2021)

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Review Biochemistry & Molecular Biology

Protein carbonylation: molecular mechanisms, biological implications, and analytical approaches

Mitsugu Akagawa

Summary: Proteins can undergo oxidative modifications, leading to protein carbonylation which is considered a major hallmark of oxidative damage. Detection and quantification of protein carbonyls can be used to assess oxidative stress levels and cellular damage. Studying the molecular mechanisms and biological implications of protein carbonylation is important for understanding oxidative damage and identifying therapeutic targets.

FREE RADICAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

An Overview of the Nrf2/ARE Pathway and Its Role in Neurodegenerative Diseases

Emilia Zgorzynska et al.

Summary: Nrf2 plays a crucial role in the expression of antioxidant and detoxifying enzymes, and dysfunctions in the Nrf2/ARE pathway can lead to various neurological pathologies. Intervention in this pathway could be a potential strategy for preventing or delaying the onset of neurodegenerative diseases. Studies have shown the beneficial effects of natural and synthetic molecules that can interact with Nrf2 to enhance its protective efficacy against oxidative stress and neuroinflammation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Redox metabolism: ROS as specific molecular regulators of cell signaling and function

Claudia Lennicke et al.

Summary: Redox reactions play a crucial role in energy metabolism and physiological functions of organisms. Reactive oxygen species (ROS), such as hydrogen peroxide, are important derivatives in normal aerobic metabolism. Hydrogen peroxide can modify protein activity by oxidizing cysteine residues, affecting enzyme and transcription factor functions and cellular processes.

MOLECULAR CELL (2021)

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Article Biochemistry & Molecular Biology

CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro

Xiaoqiang Cheng et al.

Summary: The study demonstrated that CB2 activation can inhibit oxidative stress and inflammatory response in rat NPCs induced by H2O2, as well as effectively delay the development of IVDD, providing a potential therapeutic target for the disease.

MOLECULAR MEDICINE (2021)

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Article Cell Biology

Sodium Tanshinone IIA Sulfonate Ameliorates Injury-Induced Oxidative Stress and Intervertebral Disc Degeneration in Rats by Inhibiting p38 MAPK Signaling Pathway

Shouqian Dai et al.

Summary: This study investigated the effects of sodium tanshinone IIA sulfonate (STS) on injury-induced intervertebral disc degeneration (IDD) and explored the potential mechanisms. Results showed that STS effectively attenuated disc degeneration, improved levels of COL2 and aggrecan, suppressed inflammatory factors and oxidative stress, and inhibited the p38 MAPK pathway in a rat model of IDD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Cell Biology

Mangiferin Alleviates Mitochondrial ROS in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration via Suppression of NF-κB Signaling Pathway

Haichao Yu et al.

Summary: The study showed that mangiferin alleviated inflammation and reversed the loss of major intervertebral disc components in IVDD. It also reduced reactive oxygen species production, improved mitochondrial damage, and decreased apoptosis-related parameters. Additionally, mangiferin antagonized NF-kappa B signaling pathway activation induced by TNF-alpha, providing a potential therapeutic approach for IVDD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Cell Biology

FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells

Rongjin Luo et al.

Summary: This study highlights the crucial role of FAM134B-mediated ER-phagy in apoptosis and senescence induced by AGEs in intervertebral disc cells by modulating intracellular ROS accumulation. Overexpression of FAM134B can alleviate these effects, while knockdown exacerbates them. Targeting FAM134B-mediated ER-phagy could be a promising therapeutic strategy for IDD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Cell Biology

Promoting Nrf2/Sirt3-Dependent Mitophagy Suppresses Apoptosis in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration

Sunli Hu et al.

Summary: The activation of the Nrf2/Sirt3 pathway was found to inhibit cell apoptosis and mitochondrial dysfunction in IVDD, and restore autophagic flux disturbances through its potential mechanism, showing potential therapeutic effects.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Oncology

MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma

Hyuk Moon et al.

Summary: The MAPK/ERK signaling pathway is frequently activated in liver cancer, with alternative mechanisms other than genetic mutations driving its activation. Recent studies have focused on understanding the cellular and molecular mechanisms involved in the activation of the MAPK/ERK signaling pathway in HCC, suggesting potential therapeutic strategies targeting this pathway.

CANCERS (2021)

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Review Oncology

Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer

Huayi Li et al.

Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.

CANCERS (2021)

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Review Cell Biology

Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration

Zoe Krut et al.

Summary: Intervertebral disc degeneration (IVDD) is a result of imbalanced anabolic and catabolic processes in the disc, naturally occurring with age. Current treatments lack the ability to stop disease progression or restore functionality, while stem cell-derived exosomes show potential as a therapeutic option.

CELLS (2021)

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Article Oncology

Transcription factor EB mediates oxidative stress-induced intervertebral disc degeneration via the NF-κB signaling pathway

He Liang et al.

Summary: The study indicates that TFEB expression decreases as the intervertebral disc degeneration progresses, and under oxidative stress treatment, the expression of TFEB, collagen 2, and aggrecan decreases gradually. Overexpression of TFEB can increase collagen 2 and aggrecan expression, while reducing NF-kappa B expression, potentially serving as a therapeutic target.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Surgery

Mitochondria-targeted antioxidant MitoQ ameliorates ischaemia-reperfusion injury in kidney transplantation models

M. Hamed et al.

Summary: The study demonstrated the effective uptake of MitoQ by ischemic kidneys during cold storage, improving outcomes after transplantation. MitoQ was shown to effectively ameliorate ischemia-reperfusion injury in ex vivo porcine and human models of kidney transplantation.

BRITISH JOURNAL OF SURGERY (2021)

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Review Cell & Tissue Engineering

Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions

Feng-Juan Lyu et al.

Summary: Low back pain is a common musculoskeletal disorder with inflammation playing a crucial role in disc degeneration and pain. Various animal models and signaling pathways related to painful disc degeneration have been discussed, along with potential drug candidates to suppress discogenic LBP by targeting inflammation.

BONE RESEARCH (2021)

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Article Cell Biology

Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration

Kangcheng Zhao et al.

Summary: Extracellular lactate regulates intercellular reactive oxygen species (ROS) levels through ASIC1 and ASIC3, activating the NF-kappa B signaling pathway to promote NLRP3 inflammasome activation and IL-1 beta release, ultimately contributing to NP degeneration.

CELL PROLIFERATION (2021)

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Article Allergy

The AGE-RAGE Axis and RAGE Genetics in Chronic Obstructive Pulmonary Disease

Ambika Sharma et al.

Summary: Chronic obstructive pulmonary disease (COPD) is a heterogeneous group of lung diseases characterized by limited airflow, chronic bronchitis, and emphysema. Research has shown that the receptor for advanced glycation end products (RAGE) plays an important role in the pathology of COPD, and its truncated form, soluble RAGE (sRAGE), is considered a significant marker for COPD.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2021)

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Review Medicine, Research & Experimental

Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions

Amir Kamali et al.

Summary: Low back pain is a major cause of disability, with symptomatic intervertebral disc degeneration contributing to a significant portion of cases. Current treatments often fail to address the root problem, leading to a need for novel therapies. Small molecule-based therapy shows potential in treating intervertebral disc degeneration, but is still in its early stages of development.

THERANOSTICS (2021)

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Article Cell Biology

Naringin alleviates H2O2-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells

Li-Ping Nan et al.

CONNECTIVE TISSUE RESEARCH (2020)

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Article Cell Biology

TIGAR impedes compression-induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy

Zhiliang Li et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Review Cell Biology

Nrf2-ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

Pallab Shaw et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Review Endocrinology & Metabolism

Intervertebral disc degeneration: A focus on obesity and type 2 diabetes

Francesca Cannata et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2020)

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Review Cell Biology

Mitochondria regulation in ferroptosis

Hai Wang et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2020)

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Review Cell Biology

Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen

Sidong Yang et al.

AGEING RESEARCH REVIEWS (2020)

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Article Medicine, Research & Experimental

1,4-Dihydropyridine (DHP) suppresses against oxidative stress in nucleus pulposus via activating sirtuin-1

Yuxin Song et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Medicine, Research & Experimental

Pyroptosis: A new frontier in cancer

Yuan Fang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Cell Biology

The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance

Liang Kang et al.

CELL PROLIFERATION (2020)

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Article Biochemistry & Molecular Biology

Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis

Matthew J. Silva et al.

FASEB JOURNAL (2020)

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Article Immunology

Marein protects human nucleus pulposus cells against high glucose-induced injury and extracellular matrix degradation at least partly by inhibition of ROS/NF-κB pathway

Mingyan Yao et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

Shannon Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Inhibition of Rac1 activity by NSC23766 prevents cartilage endplate degeneration via Wnt/β-catenin pathway

Chao Jiang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Medicine, Research & Experimental

Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses

Liang Kang et al.

LIFE SCIENCES (2020)

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Article Biochemical Research Methods

Lycopene alleviates disc degeneration under oxidative stress through the Nrf2 signaling pathway

Yang Lu et al.

MOLECULAR AND CELLULAR PROBES (2020)

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Review Biochemistry & Molecular Biology

8-Oxo-7,8-Dihydro-2′-Deoxyguanosine (8-oxodG) and 8-Hydroxy-2′-Deoxyguanosine (8-OHdG) as a Potential Biomarker for Gestational Diabetes Mellitus (GDM) Development

Sandra K. Urbaniak et al.

MOLECULES (2020)

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Review Cell Biology

mTOR at the nexus of nutrition, growth, ageing and disease

Grace Y. Liu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Orthopedics

The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review

K. Sun et al.

OSTEOARTHRITIS AND CARTILAGE (2020)

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Article Cell Biology

Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells

Zhibiao Bai et al.

AGING-US (2020)

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Article Engineering, Biomedical

Reactive Oxygen Species-Scavenging Scaffold with Rapamycin for Treatment of Intervertebral Disk Degeneration

Jinyu Bai et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Review Oncology

Targeting the MAPK Pathway in KRAS-Driven Tumors

Matthias Drosten et al.

CANCER CELL (2020)

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Article Orthopedics

Current Treatment Options for Intervertebral Disc Pathologies

Stephen M. Eisenstein et al.

CARTILAGE (2020)

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Review Biochemistry & Molecular Biology

Understanding MAPK Signaling Pathways in Apoptosis

Jicheng Yue et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology

Petra Cazzanelli et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Multidisciplinary Sciences

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Michael A. Badgley et al.

SCIENCE (2020)

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Article Toxicology

Toxic consequences and oxidative protein carbonylation from chloropicrin exposure in human corneal epithelial cells

Dinesh G. Goswami et al.

TOXICOLOGY LETTERS (2020)

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Article Multidisciplinary Sciences

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease

Ping-Chieh Pao et al.

NATURE COMMUNICATIONS (2020)

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Review Cell Biology

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Emad H. M. Hassanein et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Pharmacology & Pharmacy

Advanced glycation end products in diabetes, cancer and phytochemical therapy

Begum Dariya et al.

DRUG DISCOVERY TODAY (2020)

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Article Biochemistry & Molecular Biology

Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell pyroptosis via NLRP3-dependent pathway

Danshuang He et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Review Medicine, Research & Experimental

The emerging role of ferroptosis in inflammation

Yitian Sun et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Cell Biology

Aging of the cells: Insight into cellular senescence and detection Methods

Nor Shaheera Mohamad Kamal et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell

Tao Bai et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Review Immunology

Role of pyroptosis in liver diseases

Abdullah Al Mamun et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Immunology

The NF-kappa B Signaling Pathway, the Microbiota, and Gastrointestinal Tumorigenesis: Recent Advances

Chao Peng et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Cell Biology

Bmi deficiency causes oxidative stress and intervertebral disc degeneration which can be alleviated by antioxidant treatment

Qunhu Zhang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Review Veterinary Sciences

Current Understanding of the Genetics of Intervertebral Disc Degeneration

Peter J. Dickinson et al.

FRONTIERS IN VETERINARY SCIENCE (2020)

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Review Medical Laboratory Technology

Sirtuins and intervertebral disc degeneration: Roles in inflammation, oxidative stress, and mitochondrial function

Guang-Zhi Zhang et al.

CLINICA CHIMICA ACTA (2020)

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Review Pharmacology & Pharmacy

Targeting the PI3K/AKT/mTOR Pathway in Hormone-Positive Breast Cancer

Sara E. Nunnery et al.

DRUGS (2020)

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Article Multidisciplinary Sciences

Negative MAPK-ERK regulation sustains CIC-DUX4 oncoprotein expression in undifferentiated sarcoma

Yone Kawe Lin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Biochemistry & Molecular Biology

Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes

Maria Tsingas et al.

MATRIX BIOLOGY (2020)

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Review Cell Biology

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

Rui Liu et al.

CELL DEATH & DISEASE (2020)

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Review Geriatrics & Gerontology

Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia

Ishan Agrawal et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

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Review Cell Biology

Senescence and the SASP: many therapeutic avenues

Jodie Birch et al.

GENES & DEVELOPMENT (2020)

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Review Biochemistry & Molecular Biology

A Molecular Perspective on Sirtuin Activity

Carla S. S. Teixeira et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Plant Sciences

The treatment of intervertebral disc degeneration using Traditional Chinese Medicine

Liguo Zhu et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Review Cell Biology

The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors

Jinghan Zhu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Cell Biology

Allicin Attenuated Advanced Oxidation Protein Product-Induced Oxidative Stress and Mitochondrial Apoptosis in Human Nucleus Pulposus Cells

Qian Xiang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Medicine, Research & Experimental

MSC-Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via the miR-31-5p/ATF6 Axis

Lin Xie et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Cell Biology

Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway

Dong Wang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver

Erika Ramos-Tovar et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

Targeting NF-κB-Inducing Kinase (NIK) in Immunity, Inflammation, and Cancer

Kathryn M. Pflug et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Targeting Lipid Peroxidation for Cancer Treatment

Sofia M. Clemente et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4

Xuyang Zhang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Review Medicine, Research & Experimental

The role of IL-1β and TNF-α in intervertebral disc degeneration

Yongjie Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Biochemistry & Molecular Biology

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Hui Yu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Geriatrics & Gerontology

Pyroptosis Plays a Role in Osteoarthritis

Senbo An et al.

AGING AND DISEASE (2020)

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Article Medicine, Research & Experimental

Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation

Yunpeng Zhao et al.

THERANOSTICS (2020)

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Review Biochemistry & Molecular Biology

Methionine oxidation within the prion protein

John Bettinger et al.

PRION (2020)

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Article Cardiac & Cardiovascular Systems

CARD9 promotes autophagy in cardiomyocytes in myocardial ischemia/reperfusion injury via interacting with Rubicon directly

Yuanbin Li et al.

BASIC RESEARCH IN CARDIOLOGY (2020)

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Article Cell Biology

The impact of oxidative DNA damage and stress on telomere homeostasis

Ryan P. Barnes et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2019)

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Review Orthopedics

Mechanisms of endogenous repair failure during intervertebral disc degeneration

K. Ma et al.

OSTEOARTHRITIS AND CARTILAGE (2019)

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Article Biochemistry & Molecular Biology

Mitochondria and oxidative stress in ovarian endometriosis

Chaolu Chen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Age-dependent expression of the vitamin D receptor and the protective effect of vitamin D receptor activation on H2O2-induced apoptosis in rat intervertebral disc cells

Tong Tong et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

Dong Xu et al.

MOLECULES (2019)

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Article Orthopedics

Nutrient supply and nucleus pulposus cell function: effects of the transport properties of the cartilage endplate and potential implications for intradiscal biologic therapy

J. Wong et al.

OSTEOARTHRITIS AND CARTILAGE (2019)

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Article Biochemistry & Molecular Biology

The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway

Junsheng He et al.

BIOSCIENCE REPORTS (2019)

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Article Endocrinology & Metabolism

Cellular senescence in bone

Joshua N. Farr et al.

BONE (2019)

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Review Cell Biology

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

Mark S. D'Arcy

CELL BIOLOGY INTERNATIONAL (2019)

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Review Biochemistry & Molecular Biology

MAPK/ERK Signaling in Regulation of Renal Differentiation

Kristen Kurtzeborn et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Physiology

CELLULAR SENESCENCE: AGING, CANCER, AND INJURY

Arianna Calcinotto et al.

PHYSIOLOGICAL REVIEWS (2019)

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Article Biochemistry & Molecular Biology

Sirtuin 2 expression suppresses oxidative stress and senescence of nucleus pulposus cells through inhibition of the p53/p21 pathway

Maojie Yang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Review Biochemistry & Molecular Biology

Autophagy-Independent Functions of the Autophagy Machinery

Lorenzo Galluzzi et al.

CELL (2019)

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Review Biochemistry & Molecular Biology

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

Nathan Kelley et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Cell Biology

Oxidative stress-induced senescence markedly increases disc cell bioenergetics

Prashanti Patila et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2019)

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Article Cell Biology

Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

Zehan Tang et al.

CELL DEATH & DISEASE (2019)

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Article Biochemistry & Molecular Biology

Oxidative damage induces apoptosis and promotes calcification in disc cartilage endplate cell through ROS/MAPK/NF-κB pathway: Implications for disc degeneration

Yingchao Han et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Review Biochemistry & Molecular Biology

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

Toshitaka Nakamura et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2019)

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Article Biochemistry & Molecular Biology

PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy

Wen-Ning Xu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Review Biochemistry & Molecular Biology

Causative Links between Protein Aggregation and Oxidative Stress: A Review

Elise Levy et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects

Chen Xia et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Detection, identification, and quantification of oxidative protein modifications

Clare L. Hawkins et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Article Medicine, Research & Experimental

Modulatory role of HMG-CoA reductase inhibitors and ezetimibe on LDL-AGEs-induced ROS generation and RAGE-associated signalling in HEK-293 Cells

Rabia Nabi et al.

LIFE SCIENCES (2019)

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Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

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Aspirin-Mediated Attenuation of Intervertebral Disc Degeneration by Ameliorating Reactive Oxygen Species In Vivo and In Vitro

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Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion

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STEM CELL RESEARCH & THERAPY (2019)

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The impact of NF-κB signaling on pathogenesis and current treatment strategies in multiple myeloma

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BLOOD REVIEWS (2019)

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Adipose oxidative stress and protein carbonylation

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Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the Sirt1-autophagy pathway

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition

Yu Chen et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Mitochondrial dysfunction and oxidative stress in heart disease

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EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Interventions targeted at oxidatively generated modifications of nucleic acids focused on urine and plasma markers

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FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Orthopedics

TFEB protects nucleus pulposus cells against apoptosis and senescence via restoring autophagic flux

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OSTEOARTHRITIS AND CARTILAGE (2019)

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Article Clinical Neurology

Estrogen Deficiency Exacerbates Intervertebral Disc Degeneration Induced by Spinal Instability in Rats

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SPINE (2019)

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Genetic Predisposition to Symptomatic Lumbar Disk Herniation in Pediatric and Young Adult Patients

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SPINE (2019)

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Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration

Liang Kang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Cysteine Disulfides (Cys-ss-X) as Sensitive Plasma Biomarkers of Oxidative Stress

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SCIENTIFIC REPORTS (2019)

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NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

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REDOX BIOLOGY (2019)

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Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation

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AMPK: guardian of metabolism and mitochondrial homeostasis

Sebastien Herzig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Targeting RAGE Signaling in Inflammatory Disease

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ANNUAL REVIEW OF MEDICINE, VOL 69 (2018)

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Carnosine and advanced glycation end products: a systematic review

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AMINO ACIDS (2018)

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Review Biochemistry & Molecular Biology

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

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Resveratrol enhances matrix biosynthesis of nucleus pulposus cells through activating autophagy via the PI3K/Akt pathway under oxidative damage

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Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

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Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway

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FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Article Peripheral Vascular Disease

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults

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HYPERTENSION (2018)

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Melatonin resists oxidative stress-induced apoptosis in nucleus pulposus cells

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LIFE SCIENCES (2018)

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Proteome oxidative carbonylation during oxidative stress-induced premature senescence of WI-38 human fibroblasts

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MECHANISMS OF AGEING AND DEVELOPMENT (2018)

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The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression

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PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2018)

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The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway

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CELL DEATH & DISEASE (2018)

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Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

Jian Chen et al.

CELL DEATH & DISEASE (2018)

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A retrospective study: Does cigarette smoking induce cervical disc degeneration?

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INTERNATIONAL JOURNAL OF SURGERY (2018)

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Progress in Applications of Prussian Blue Nanoparticles in Biomedicine

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Elevated levels of 8-oxoGuo and 8-oxodG in individuals with severe mental illness - An autopsy-based study

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Protein aggregation - Mechanisms, detection, and control

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Cellular senescence: Molecular mechanisms and pathogenicity

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Correction Clinical Neurology

Intervertebral Disk Degeneration and Repair (vol 80, pg S46, 2018)

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17 beta-Estradiol inhibits intervertebral disc degeneration by down-regulating MMP-3 and MMP-13 and up-regulating type II collagen in a rat model

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Pkcδ Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products (Ages)

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AGING AND DISEASE (2018)

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Article Biochemistry & Molecular Biology

Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration

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REDOX BIOLOGY (2018)

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Matrine Attenuates D-Galactose-Induced Aging-Related Behavior in Mice via Inhibition of Cellular Senescence an Oxidative Stress

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Estradiol Alleviates Intervertebral Disc Degeneration through Modulating the Antioxidant Enzymes and Inhibiting Autophagy in the Model of Menopause Rats

Lin-Yu Jin et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Article Biochemistry & Molecular Biology

Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway

Wenping Wang et al.

BIOSCIENCE REPORTS (2018)

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Article Integrative & Complementary Medicine

Therapeutic Potential of Naringin for Intervertebral Disc Degeneration: Involvement of Autophagy Against Oxidative Stress-Induced Apoptosis in Nucleus Pulposus Cells

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AMERICAN JOURNAL OF CHINESE MEDICINE (2018)

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Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy

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THERANOSTICS (2018)

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Association between menopause and lumbar disc degeneration: an MRI study of 1,566 women and 1,382 men

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MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2017)

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Oxidative stress, protein damage and repair in bacteria

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Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

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Review Cell Biology

ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration

Chencheng Feng et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

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Defects of the vertebral end plate: implications for disc degeneration depend on size

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SPINE JOURNAL (2017)

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Review Clinical Neurology

Treatment of chronic low back pain - new approaches on the horizon

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Review Multidisciplinary Sciences

Inflammatory biomarkers of low back pain and disc degeneration: a review

Aysha N. Khan et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

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Article Cell Biology

Salubrinal Suppresses IL-17-Induced Upregulation of MMP-13 and Extracellular Matrix Degradation Through the NF-kB Pathway in Human Nucleus Pulposus Cells

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INFLAMMATION (2016)

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Review Medicine, Research & Experimental

Molecular mechanisms of cell death in intervertebral disc degeneration (Review)

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INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

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Review Orthopedics

Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration

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OSTEOARTHRITIS AND CARTILAGE (2016)

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Article Cell Biology

The Natural Polyphenol Epigallocatechin Gallate Protects Intervertebral Disc Cells from Oxidative Stress

Olga Krupkova et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Review Cell Biology

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Review Neurosciences

The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

Heidi Martini-Stoica et al.

TRENDS IN NEUROSCIENCES (2016)

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Article Cell Biology

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

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CELL DEATH & DISEASE (2016)

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Review Medicine, Research & Experimental

mTOR: a pharmacologic target for autophagy regulation

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JOURNAL OF CLINICAL INVESTIGATION (2015)

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Review Multidisciplinary Sciences

Inflammation in intervertebral disc degeneration and regeneration

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JOURNAL OF THE ROYAL SOCIETY INTERFACE (2015)

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Review Cell Biology

Oxidative Stress and Adipocyte Biology: Focus on the Role of AGEs

Florence Boyer et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

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Article Rheumatology

Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration

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ARTHRITIS RESEARCH & THERAPY (2015)

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Review Biochemistry & Molecular Biology

Oxidative stress and autophagy: the clash between damage and metabolic needs

G. Filomeni et al.

CELL DEATH AND DIFFERENTIATION (2015)

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Article Cell & Tissue Engineering

DISC IN FLAMES: ROLES OF TNF-α AND IL-1β IN INTERVERTEBRAL DISC DEGENERATION

Z. I. Johnson et al.

EUROPEAN CELLS & MATERIALS (2015)

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Article Geriatrics & Gerontology

Oxidative stress participates in age-related changes in rat lumbar intervertebral discs

Gang Hou et al.

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2014)

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Article Biochemistry & Molecular Biology

Differential expression of extracellular-signal-regulated kinase 5 (ERK5) in normal and degenerated human nucleus pulposus tissues and cells

Weiguo Liang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

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Review Biochemistry & Molecular Biology

Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid

Henrik E. Poulsen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)

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Article Cell Biology

Glutathione protects human nucleus pulposus cells from cell apoptosis and inhibition of matrix synthesis

Dazhi Yang et al.

CONNECTIVE TISSUE RESEARCH (2014)

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Article Orthopedics

Accelerated premature stress-induced senescence of young annulus fibrosus cells of rats by high glucose-induced oxidative stress

Jong-Soo Park et al.

INTERNATIONAL ORTHOPAEDICS (2014)

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Review Biophysics

The Role Of Extracellular Matrix Elasticity and Composition In Regulating the Nucleus Pulposus Cell Phenotype in the Intervertebral Disc: A Narrative Review

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JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2014)

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Review Spectroscopy

PROTEIN CARBONYLATION AS A MAJOR HALLMARK OF OXIDATIVE DAMAGE: UPDATE OF ANALYTICAL STRATEGIES

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MASS SPECTROMETRY REVIEWS (2014)

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Review Endocrinology & Metabolism

Autophagy-a key player in cellular and body metabolism

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NATURE REVIEWS ENDOCRINOLOGY (2014)

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Review Rheumatology

Role of cytokines in intervertebral disc degeneration: pain and disc content

Makarand V. Risbud et al.

NATURE REVIEWS RHEUMATOLOGY (2014)

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Article Cell Biology

Increased Macroautophagy in the Pathological Process of Intervertebral Disc Degeneration in Rats

Wei Ye et al.

CONNECTIVE TISSUE RESEARCH (2013)

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Article Orthopedics

High glucose-induced oxidative stress promotes autophagy through mitochondrial damage in rat notochordal cells

Eun-Young Park et al.

INTERNATIONAL ORTHOPAEDICS (2013)

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Article Orthopedics

Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral disc degeneration

Libo Jiang et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2013)

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Review Cell Biology

Oxidative Stress and Nucleic Acid Oxidation in Patients with Chronic Kidney Disease

Chih-Chien Sung et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

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Review Biochemistry & Molecular Biology

Oxidative protein damage and the proteasome

S. Grimm et al.

AMINO ACIDS (2012)

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Article Cell Biology

Age-Related Oxidative Stress Compromises Endosomal Proteostasis

Elvira S. Cannizzo et al.

CELL REPORTS (2012)

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Review Chemistry, Multidisciplinary

Free Radical Lipid Peroxidation: Mechanisms and Analysis

Huiyong Yin et al.

CHEMICAL REVIEWS (2011)

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Article Orthopedics

Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes

J. Kim et al.

OSTEOARTHRITIS AND CARTILAGE (2010)

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Article Clinical Neurology

Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs

Ki-Won Kim et al.

SPINE JOURNAL (2009)

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Review Biochemistry & Molecular Biology

Many roads lead to oncogene-induced senescence

S. Courtois-Cox et al.

ONCOGENE (2008)

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Article Clinical Neurology

Senescence in cells of the aging and degenerating intervertebral disc -: Immunolocalization of senescence-associated β-galactosidase in human and sand rat discs

Helen E. Gruber et al.

SPINE (2007)

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Article Multidisciplinary Sciences

Dynamic redox control of NF-κB through glutaredoxin-regulated S-glutathionylation of inhibitory κB kinase β

Niki L. Reynaert et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Clinical Neurology

Senescence in human intervertebral discs

S. Roberts et al.

EUROPEAN SPINE JOURNAL (2006)

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Review Biochemistry & Molecular Biology

Protein aggregation and neurodegenerative disease

CA Ross et al.

NATURE MEDICINE (2004)

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