Gut microbiome lipid metabolism and its impact on host physiology

Metabolites produced by commensal gut microbes impact host health through their recognition by the im-mune system and their influence on numerous metabolic pathways. Notably, the gut microbiota can both transform and synthesize lipids as well as break down dietary lipids to generate secondary metabolites with host modulatory properties. Although lipids have largely been consigned to structural roles, particularly in cell membranes, recent research has led to an increased appreciation of their signaling activities, with po-tential impacts on host health and physiology. This review focuses on studies that highlight the functions of bioactive lipids in mammalian physiology, with a special emphasis on immunity and metabolism.

Automated summary

Metabolites from commensal gut microbes have significant impacts on host health through immune recognition and modulation of various metabolic pathways. The gut microbiota plays a dual role in transforming and synthesizing lipids, as well as breaking down dietary lipids to generate secondary metabolites with host regulatory properties. Recent research has highlighted the signaling activities of lipids, which have potential effects on host health and physiology. This review focuses on the functions of bioactive lipids in mammalian physiology, with a particular emphasis on immunity and metabolism.