☆ 4.6 Article

MiR-17-5p/RRM2 regulated gemcitabine resistance in lung cancer A549 cells

CELL CYCLE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Genetics & Heredity

MiR-421 promotes lipid metabolism by targeting PTEN via activating PI3K/AKT/mTOR pathway in non-small cell lung cancer

Yong-Jie Xu et al.

Summary: MiR-421 promotes lipid metabolism through targeting PTEN via activation of the PI3K/AKT/mTOR pathway in NSCLC. This study provides a deeper insight into the prognostic strategies for lung cancer by understanding the specific mechanism of miR-421 in lipid metabolism.

EPIGENOMICS (2022)

添加到收藏夹

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Review Oncology

Targeting cell-cycle machinery in cancer

Jan M. Suski et al.

Summary: Abnormal activity of the core cell-cycle machinery drives tumorigenesis in most tumor types, with cell-cycle proteins regulating a wide range of cellular functions in addition to cell division. Inhibiting different cell-cycle proteins shows potential as an effective anti-cancer strategy, as evidenced by the clinical success of CDK4/6 inhibitors.

CANCER CELL (2021)

添加到收藏夹

Review Cell Biology

Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability

Rafaela Fagundes et al.

Summary: DNA replication must be precisely controlled, and cell cycle transitions are regulated by the Cyclin-Dependent Kinases (CDKs) family. The Cyclin E/CDK2 complex controls cell cycle progression and DNA replication through phosphorylation of specific substrates in normal cycles, while its oncogenic activation causes replication stress and genomic instability.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Review Cell Biology

Cyclin E in normal physiology and disease states

Chen Chu et al.

Summary: E-type cyclins, especially cyclin E, play a crucial role in cell cycle progression by activating CDK2. Abnormally elevated activity of cyclin E-CDK2 has been observed in various human tumors, and cyclin E overexpression is linked to resistance of tumor cells to therapeutic agents. Beyond cell proliferation and tumorigenesis, cyclin E may regulate a diverse array of physiological and pathological processes.

TRENDS IN CELL BIOLOGY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

M1 Macrophage-Derived Exosomes Loaded with Gemcitabine and Deferasirox against Chemoresistant Pancreatic Cancer

Yongmei Zhao et al.

Summary: This study developed a specific drug delivery system based on M1 macrophage-derived exosomes for pancreatic cancer with chemoresistance. The nanoformulation combining GEM and DFX in M1Exo significantly enhanced therapeutic efficacy against GEM-resistant cancer cells.

PHARMACEUTICS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting CDK2 in cancer: challenges and opportunities for therapy

Solomon Tadesse et al.

DRUG DISCOVERY TODAY (2020)

添加到收藏夹

Review Oncology

Radiosensitising Cancer Using Phosphatidylinositol-3-Kinase (PI3K), Protein Kinase B (AKT) or Mammalian Target of Rapamycin (mTOR) Inhibitors

Kasun Wanigasooriya et al.

CANCERS (2020)

添加到收藏夹

Article Respiratory System

miRNA-425-5p enhances lung cancer growth via the PTEN/PI3K/AKT signaling axis

Jin-shan Zhou et al.

BMC PULMONARY MEDICINE (2020)

添加到收藏夹

Article Cell Biology

High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma

Cheng-Yu Jin et al.

Aging-US (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

MiR-20a-5p regulates gemcitabine chemosensitivity by targeting RRM2 in pancreatic cancer cells and serves as a predictor for gemcitabine-based chemotherapy

Huimin Lu et al.

BIOSCIENCE REPORTS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Down-regulation of CCNE1 expression suppresses cell proliferation and sensitizes gastric carcinoma cells to Cisplatin

Chao Zhang et al.

BIOSCIENCE REPORTS (2019)

添加到收藏夹

Article Oncology

Screening miRNAs associated with resistance gemcitabine from exosomes in A549 lung cancer cells

Ai-Ling Liang et al.

CANCER MANAGEMENT AND RESEARCH (2019)

添加到收藏夹

Review Oncology

Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy

Lais Osmani et al.

SEMINARS IN CANCER BIOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

EGFR-TKIs resistance via EGFR-independent signaling pathways

Qian Liu et al.

MOLECULAR CANCER (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

AKT/PKB Signaling: Navigating the Network

Brendan D. Manning et al.

CELL (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

被撤回的出版物: MiR-17-5p Up-Regulates YES1 to Modulate the Cell Cycle Progression and Apoptosis in Ovarian Cancer Cell Lines (Retracted article. See vol. 122, 2021)

Lan Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Ribonucleotide Reductase Subunit M2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma: Effects of Gender and Smoking Status

Vei Mah et al.

PLOS ONE (2015)

添加到收藏夹

Article Oncology

Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer

Swati Dhar et al.

ONCOTARGET (2015)

添加到收藏夹

Article Oncology

AKT-Induced Tamoxifen Resistance Is Overturned by RRM2 Inhibition

Khyati N. Shah et al.

MOLECULAR CANCER RESEARCH (2014)

添加到收藏夹

Review Oncology

Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway

Howard A. Burris

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2013)

添加到收藏夹

Article Oncology

miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells

Ai-Yu Gong et al.

BMC CANCER (2012)

添加到收藏夹

Article Pharmacology & Pharmacy

Checks and balances: Interplay of RTKs and PTPs in cancer progression

Sarita K. Sastry et al.

BIOCHEMICAL PHARMACOLOGY (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mammalian cyclin-dependent kinases

M Malumbres et al.

TRENDS IN BIOCHEMICAL SCIENCES (2005)

添加到收藏夹

Review Oncology

PI3K/Akt signalling pathway and cancer

JAF Vara et al.

CANCER TREATMENT REVIEWS (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.