☆ 4.4 Article

The inhibitory potential of chemical constituents of Ficus carica targeting interleukin-6 (IL-6) mediated inflammation

CELL BIOCHEMISTRY AND FUNCTION (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer's Disease

Hafsa Amat-ur-Rasool et al.

Summary: This study ranked phytochemicals with reported anti-acetylcholinesterase (AChE) activity based on in silico simulations and selected compounds with similar or higher binding affinity to AChE as galantamine. Novel dual-binding site heterodimeric drugs were designed using these compounds and showed potent inhibition of AChE and butyrylcholinesterase (BuChE) in computational experiments. The designed heterodimers displayed enhanced affinity to the target enzymes compared to the ChEI drug donepezil. In addition, the heterodimers showed drug-likeliness properties and low predicted toxicity. This study suggests that phytochemicals could be a valuable source for the development of novel ChEIs with improved efficacy and reduced toxicity.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2022)

添加到收藏夹

Review Immunology

The role of IL-6 and IL-6 blockade in COVID-19

Nicola Potere et al.

Summary: IL-6 is a key pro-inflammatory cytokine in COVID-19 patients, particularly in those with severe disease. Pharmacological blockade of the IL-6 signaling pathway has shown promising results in improving outcomes, especially when administered early in the disease course. Further research is needed to better understand the role of IL-6 in different COVID-19 phenotypes and identify patient subgroups that may benefit the most from IL-6 pathway inhibition.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Green synthesis of gold nanoparticles from Manilkara zapota L. extract and the evaluation of its intrinsic in vivo antiarthritic potential

Mahnoor Ijaz et al.

Summary: The aqueous extract and biosynthesized nanoparticles of Manilkara zapota exhibit significant anti-inflammatory and analgesic activity against arthritis in rats. Nanoparticles show more pronounced antiarthritic effects compared to the aqueous extract, with free radical scavenging and reduction of TNF-alpha playing important roles in their activity. Further research is needed to identify the active phytochemical constituents responsible for the antiarthritic effects.

RSC ADVANCES (2021)

添加到收藏夹

Article Biochemical Research Methods

Inhibitory Potential of Phytochemicals on Interleukin-6-Mediated T-Cell Reduction in COVID-19 Patients: A Computational Approach

Arif Malik et al.

Summary: The recent COVID-19 pandemic has caused a large death toll and no cure or vaccine has been found. Patients suffer from multi-organ dysfunction and acute respiratory distress syndrome, often due to cytokine storm, particularly high levels of IL-6. Blocking IL-6 has been proposed as a potential therapeutic strategy.

BIOINFORMATICS AND BIOLOGY INSIGHTS (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Tariq Khan et al.

Summary: Plant-based compounds show potential in fighting coronaviruses, with active ingredients like glycyrrhizin demonstrating promising results. These compounds act on the virus through various mechanisms, offering a potential alternative for COVID-19 treatment.

BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY (2021)

添加到收藏夹

Article Immunology

TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

Dandan Wu et al.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting cancer stem cell pathways for cancer therapy

Liqun Yang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

添加到收藏夹

Article Chemistry, Medicinal

Monoterpene indole alkaloids from Rhazya stricta

Abrar Ahmed et al.

FITOTERAPIA (2018)

添加到收藏夹

Review Cell Biology

Acute Inflammation and Metabolism

Miguel Lourenco Varela et al.

INFLAMMATION (2018)

添加到收藏夹

Review Immunology

Interleukin-6, A Cytokine Critical to Mediation of Inflammation, Autoimmunity and Allograft Rejection: Therapeutic Implications of IL-6 Receptor Blockade

Stanley C. Jordan et al.

TRANSPLANTATION (2017)

添加到收藏夹

Review Rheumatology

The biology behind interleukin-6 targeted interventions

Xiao Liu et al.

CURRENT OPINION IN RHEUMATOLOGY (2016)

添加到收藏夹

Article Chemistry, Medicinal

Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database

Jing Wang et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2016)

添加到收藏夹

Article Biochemical Research Methods

Interaction Analysis of T7 RNA Polymerase with Heparin and Its Low Molecular Weight Derivatives - An In Silico Approach

Subhomoi Borkotoky et al.

BIOINFORMATICS AND BIOLOGY INSIGHTS (2016)

添加到收藏夹

Review Immunology

IL-6 as a keystone cytokine in health and disease

Christopher A. Hunter et al.

NATURE IMMUNOLOGY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

GalaxySite: ligand-binding-site prediction by using molecular docking

Lim Heo et al.

NUCLEIC ACIDS RESEARCH (2014)

添加到收藏夹

Review Plant Sciences

Traditional uses, phytochemistry and pharmacology of Ficus carica: A review

Shamkant B. Badgujar et al.

PHARMACEUTICAL BIOLOGY (2014)

添加到收藏夹

Article Cell Biology

IL-6 in Inflammation, Immunity, and Disease

Toshio Tanaka et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

G. Madhavi Sastry et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2013)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

Inflammation 2010: New Adventures of an Old Flame

Ruslan Medzhitov

CELL (2010)

添加到收藏夹

Article Critical Care Medicine

Microvascular thrombosis and multiple organ dysfunction syndrome

Satoshi Gando

CRITICAL CARE MEDICINE (2010)

添加到收藏夹

Article Pharmacology & Pharmacy

Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. leaves

Manjit Singh et al.

PHARMACOGNOSY RESEARCH (2010)

添加到收藏夹

Review Multidisciplinary Sciences

Origin and physiological roles of inflammation

Ruslan Medzhitov

NATURE (2008)

添加到收藏夹

Article Chemistry, Medicinal

Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

Richard A. Friesner et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

添加到收藏夹

Article Chemistry, Medicinal

Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring

Paul D. Lyne et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

添加到收藏夹

Article Chemistry, Medicinal

Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

RA Friesner et al.

JOURNAL OF MEDICINAL CHEMISTRY (2004)

添加到收藏夹

Article Chemistry, Medicinal

Glide: A new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening

TA Halgren et al.

JOURNAL OF MEDICINAL CHEMISTRY (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.