PDLIM2 can inactivate the TGF-β/Smad pathway to inhibit the malignant behavior of ovarian cancer cells

Article Biotechnology & Applied Microbiology

Procyanidin B2 inhibits angiogenesis and cell growth in oral squamous cell carcinoma cells through the vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR2) pathway

Qiurong Sun et al.

Summary: This study found that PB2 can inhibit angiogenesis and cell growth in oral squamous cell carcinoma by suppressing the VEGF/VEGFR2 pathway.

BIOENGINEERED (2022)

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Review Biochemistry & Molecular Biology

PDLIM2: Signaling pathways and functions in cancer suppression and host immunity

Zong Sheng Guo et al.

Summary: PDZ and LIM domain-containing proteins, such as PDLIM2, play crucial roles in cytoskeleton organization, cell polarization, and differentiation. PDLIM2 regulates the stability and activity of transcription factors, affecting inflammation, immunity, and cancer. It acts as a tumor suppressor in various tissues but can also promote cancer cell proliferation and metastasis in certain types of cancers.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Biotechnology & Applied Microbiology

PDLIM2 prevents the malignant phenotype of hepatocellular carcinoma cells by negatively regulating β-catenin

Xiaoming Jiang et al.

Summary: Hepatocellular carcinoma (HCC) is a common and deadly malignancy worldwide. This study found that the downregulation of PDLIM2 in HCC is associated with poor prognosis, and overexpressed PDLIM2 can inhibit HCC cell proliferation, migration, invasion, and EMT by regulating beta-catenin, suggesting PDLIM2 as a promising therapeutic target for HCC.

CANCER GENE THERAPY (2021)

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Article Cell Biology

RAD51AP1 promotes progression of ovarian cancer via TGF-β/Smad signalling pathway

Hongyu Zhao et al.

Summary: This study identified RAD51AP1 as a hub gene associated with poor survival in ovarian cancer patients, with its up-regulation closely related to mutations and potential promotion of ovarian cancer progression through the TGF-beta/Smad signaling pathway.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Oncology

Lidocaine inhibits the metastatic potential of ovarian cancer by blocking NaV1.5-mediated EMT and FAK/Paxillin signaling pathway

Chang Liu et al.

Summary: Lidocaine inhibits the malignancy of ovarian cancer by blocking Na(V)1.5 and enhances the chemotherapeutic efficiency of cisplatin. Downregulation of Na(V)1.5 can inhibit the malignant properties of ovarian cancer cells through inactivating FAK/Paxillin signaling pathway. The translational value of lidocaine as an adjuvant treatment for ovarian cancer warrants further investigation.

CANCER MEDICINE (2021)

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Review Cell Biology

Targeting Myeloid-Derived Suppressor Cells in Ovarian Cancer

Seiji Mabuchi et al.

Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in ovarian cancer, with increased frequencies associated with poor prognosis. Depletion of MDSCs can significantly inhibit tumor growth and enhance the efficacy of existing anticancer therapies.

CELLS (2021)

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Review Biochemistry & Molecular Biology

Metalloproteinases in Ovarian Cancer

Preston Carey et al.

Summary: Proteases, particularly those of the matrix metalloproteinase family, play a crucial role in ovarian cancer progression and metastasis by enhancing migratory ability, ECM breakdown, and tumor support system development. Upregulation of certain proteases influences angiogenesis for tumor growth and development of metastatic implants.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Therapeutic Strategies for Targeting Ovarian Cancer Stem Cells

Wookyeom Yang et al.

Summary: Ovarian cancer is a fatal gynecological malignancy, and its treatment remains a challenge. Cancer stem cells (CSCs) play a key role in cancer relapse and treatment resistance, with their malignancy regulated by cell surface receptors and intracellular factors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Ovarian Cancer Immunotherapy and Personalized Medicine

Susan Morand et al.

Summary: Response to immunotherapy in ovarian cancer is limited, but stratification by tumor biomarkers may improve predictiveness. Future directions include utilizing these biomarkers to select ideal candidates, increasing the likelihood of success with immunotherapy in ovarian cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

PDLIM2 Suppression Inhibit Proliferation and Metastasis in Kidney Cancer

Hyeong-Dong Yuk et al.

Summary: Kidney cancer is a common malignant tumor with early detection improving, yet metastatic cases still exist. PDLIM2 plays a crucial role in cancer formation and metastasis, presenting a potential new therapeutic target for metastatic kidney cancer.

CANCERS (2021)

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Review Cell Biology

Ovarian-Cancer-Associated Extracellular Vesicles: Microenvironmental Regulation and Potential Clinical Applications

Priyakshi Kalita-de Croft et al.

Summary: Ovarian cancer is one of the most diagnosed gynecological cancers in women, often diagnosed at an advanced stage due to the lack of effective early screening. Extracellular vesicles play a crucial role in the tumor microenvironment of ovarian cancer, with potential applications in diagnosis, delivery of therapeutic agents, and disease monitoring.

CELLS (2021)

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Article Oncology