4.8 Article

HIV-1 remission and possible cure in a woman after haplo-cord blood transplant

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Population Representation in HIV Cure Research: A Review of Diversity Within HIV Cure Studies Based in the United States

Carly Roberts et al.

Summary: There is insufficient consideration and reporting of diversity in HIV cure research studies, highlighting the need to recruit diverse participants and report demographic data.

AIDS RESEARCH AND HUMAN RETROVIRUSES (2022)

Article Multidisciplinary Sciences

The major genetic risk factor for severe COVID-19 is associated with protection against HIV

Hugo Zeberg

Summary: Genetic risk factors, particularly a segment inherited from Neandertals on chromosome 3, influence the outcome of COVID-19. The risk-associated DNA segment modulates the expression of chemokine receptors, including CCR5, resulting in a lower risk of HIV infection by about 27% in carriers of the risk variant.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Virology

Autopsy Study Defines Composition and Dynamics of the HIV-1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells

Laura E. P. Huyveneers et al.

Summary: After CCR5 Delta 32/Delta 32 allo-HSCT, HIV-1-DNA became undetectable in PBMCs, but the identical variants were still present in post-mortem tissues, indicating the importance of these tissues as viral reservoirs.

VIRUSES-BASEL (2022)

Article Surgery

Association of antiviral prophylaxis and rituximab use with posttransplant lymphoproliferative disorders (PTLDs): A nationwide cohort study

Laura N. Walti et al.

Summary: Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation (SOT), mostly associated with Epstein-Barr virus (EBV) infection. The role of antiviral prophylaxis or rituximab therapy in preventing PTLD in SOT recipients is controversial. However, receiving rituximab as induction treatment was associated with a significantly longer PTLD-free survival time in patients.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Review Biochemistry & Molecular Biology

Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

Steven G. Deeks et al.

Summary: Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. Various methods including immune activators, neutralizing antibodies, therapeutic vaccines, and gene editing tools have shown promise in curing HIV in nonhuman primate models, with optimism for human clinical trials. Future HIV cure strategies may focus on in vivo delivery of gene-editing tools to target the virus, boost immunity, or protect cells from infection.

NATURE MEDICINE (2021)

Article Virology

Clinical validation of a quantitative HIV-1 DNA droplet digital PCR assay: Applications for detecting occult HIV-1 infection and monitoring cell-associated HIV-1 dynamics across different subtypes in HIV-1 prevention and cure trials

Laura Powell et al.

Summary: The study clinically validated an HIV-1 DNA quantitative assay using droplet digital PCR (ddPCR) across different HIV-1 subtypes. The assay exhibited reliability and reproducibility, with high analytical specificity and sensitivity to near single copy level, across multiple HIV-1 subtypes, and a limit of detection of 4.09 copies/ million PBMCs. This assay has applications for detecting occult HIV-1 infection in the setting of combination and long-acting regimens used for HIV-1 prevention, across different HIV-1 subtypes, in infants and adults, and in HIV-1 cure interventions.

JOURNAL OF CLINICAL VIROLOGY (2021)

Article Infectious Diseases

From Berlin to London: HIV-1 Reservoir Reduction Following Stem Cell Transplantation

Cecilia A. Prator et al.

CURRENT HIV/AIDS REPORTS (2020)

Article Immunology

Haemopoietic cell transplantation in patients living with HIV

Richard F. Ambinder et al.

LANCET HIV (2020)

Article Medicine, Research & Experimental

Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease

Sherrie J. Divito et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Multidisciplinary Sciences

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

Ravindra K. Gupta et al.

NATURE (2019)

Article Medicine, General & Internal

CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia

Lei Xu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Multidisciplinary Sciences

Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab

Carla Serra-Peinado et al.

NATURE COMMUNICATIONS (2019)

Review Immunology

HIV-1 reservoir dynamics in CD4+T cells

Katherine M. Bruner et al.

CURRENT OPINION IN HIV AND AIDS (2019)

Review Immunology

The B-Cell Follicle in HIV Infection: Barrier to a Cure

Matthew P. Bronnimann et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Immunology

Human Immunodeficiency Virus Type 1 Persistence Following Systemic Chemotherapy for Malignancy

Timothy J. Henrich et al.

JOURNAL OF INFECTIOUS DISEASES (2017)

Review Infectious Diseases

Stem cell transplantation in strategies for curing HIV/AIDS

Gero Huetter

AIDS RESEARCH AND THERAPY (2016)

Article Hematology

8/8 and 10/10 High-Resolution Match Rate for the Be The Match Unrelated Donor Registry

Jason Dehn et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2015)

Article Immunology

Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies

Amanda M. Crooks et al.

JOURNAL OF INFECTIOUS DISEASES (2015)

Article Multidisciplinary Sciences

Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

Meghan K. Rothenberger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Immunology

Changes in HIV reservoirs during long-term antiretroviral therapy

Feiyu F. Hong et al.

CURRENT OPINION IN HIV AND AIDS (2015)

Article Medicine, General & Internal

Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation Report of 2 Cases

Timothy J. Henrich et al.

ANNALS OF INTERNAL MEDICINE (2014)

Review Immunology

Immune responses in neonates

Saleem Basha et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2014)

Article Medicine, General & Internal

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

Pablo Tebas et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

HLA Match Likelihoods for Hematopoietic Stem-Cell Grafts in the US Registry

Loren Gragert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Letter Medicine, General & Internal

More on Shift of HIV Tropism in Stem-Cell Transplantation with CCR5 Delta32/Delta32 Mutation

Gero Huetter

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Letter Medicine, General & Internal

Shift of HIV Tropism in Stem-Cell Transplantation with CCR5 Delta32 Mutation

Lambros Kordelas et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Multidisciplinary Sciences

Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1

Alison L. Hill et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Hematology

Hematopoietic Cell Transplantation with Cord Blood for Cure of HIV Infections

Lawrence D. Petz et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2013)

Article Cell & Tissue Engineering

Cord Blood Transplantation for Cure of HIV Infections

Lawrence Petz

STEM CELLS TRANSLATIONAL MEDICINE (2013)

Article Biochemistry & Molecular Biology

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

Nicolas Chomont et al.

NATURE MEDICINE (2009)

Article Medicine, General & Internal

Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantaion

Gero Huetter et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Review Immunology

Immune activation and AIDS pathogenesis

Donald L. Sodora et al.

Article Biochemistry & Molecular Biology

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

JD Siliciano et al.

NATURE MEDICINE (2003)

Article Multidisciplinary Sciences

HIV preferentially infects HIV-specific CD4+ T cells

DC Douek et al.

NATURE (2002)