HDL particles and infection-related death: when size matters

Article Cardiac & Cardiovascular Systems

Lower levels of small HDL particles associated with increased infectious disease morbidity and mortality: a population-based cohort study of 30 195 individuals

Mads Harslof et al.

Summary: This study used NMR spectroscopy to measure HDL particle counts in 30,195 Danish individuals and further subdivided them according to particle size. The study found that a decrease in the number of small and medium HDL particles was associated with an increased incidence and mortality of infectious diseases. This suggests that low levels of HDL cholesterol may affect the risk of infectious diseases.

CARDIOVASCULAR RESEARCH (2023)

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Review Cardiac & Cardiovascular Systems

Cholesteryl ester transfer protein inhibitors: from high-density lipoprotein cholesterol to low-density lipoprotein cholesterol lowering agents?

Nick S. Nurmohamed et al.

Summary: Cholesteryl ester transfer protein (CETP) is a liver-synthesized glycoprotein that facilitates the transfer of cholesterol esters and triglycerides between different lipoprotein particles. Recent studies have shown that the benefit of CETP inhibitors in atherosclerotic cardiovascular disease (ASCVD) is primarily due to the reduction of LDL-C and apoB, rather than an increase in HDL-C. Genetic evidence supports the use of CETP inhibitors, as they achieve similar reductions in ASCVD risk as other lipid-lowering medications. The newest generation of CETP inhibitors not only lower LDL-C, but also reduce the risk of new-onset diabetes and improve glucose tolerance and insulin sensitivity.

CARDIOVASCULAR RESEARCH (2022)

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Article Cardiac & Cardiovascular Systems

Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis

Mark Trinder et al.

Summary: Clinical genetics and humanized mouse models suggest that inhibiting CETP may preserve high-density lipoprotein levels and improve outcomes for individuals with sepsis.

CIRCULATION (2021)

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Article Anesthesiology