N,N-dimethyl chitosan oligosaccharide (DMCOS) promotes antifungal activity by causing mitochondrial damage

Article Food Science & Technology

Synthesis and antibacterial properties of new monomethyl fumaric acid-modified chitosan oligosaccharide derivatives

Lingyu Zhao et al.

Summary: The introduction of monomethyl fumaric acid (MFA) into chitosan oligosaccharide (COS) derivatives significantly enhances their antibacterial properties, suggesting a potential avenue for the development of novel antibacterial agents.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Evaluation of Antibacterial and Antifungal Properties of Low Molecular Weight Chitosan Extracted from Hermetia illucens Relative to Crab Chitosan

Adelya Khayrova et al.

Summary: This study investigates the depolymerisation of insect and crab chitosans using novel enzymes. The resulting low molecular weight chitosans show improved biological activity, indicating the potential of Hermetia illucens as a new source.

MOLECULES (2022)

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Article Polymer Science

One step synthesis of an amino acid derived particles, poly(L-Arginine) and its biomedical application

Nurettin Sahiner

Summary: This study reported the single-step synthesis of poly(L-Arginine) (p(L-Arg)) particles using a microemulsion crosslinking method, with successful crosslinking confirmed by elemental analysis and SEM observation. The biomedical potential of p(L-Arg) particles was thoroughly investigated, including degradability, blood compatibility, antioxidant and antimicrobial properties.

POLYMERS FOR ADVANCED TECHNOLOGIES (2022)

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Article Plant Sciences

Antimicrobial and Antibiofilm Effect of Inulin-Type Fructans, Used in Synbiotic Combination with Lactobacillus spp. Against Candida albicans

Ricardo Garcia-Gamboa et al.

Summary: This study investigated the antibacterial effects of prebiotics and probiotics in combination on Candida albicans. The results showed that the combination of inulin-type fructans with Lactobacillus paracasei or Lactobacillus plantarum inhibited the growth and biofilm formation of C. albicans. Gas chromatography analysis revealed that lactic acid was the dominant metabolite produced.

PLANT FOODS FOR HUMAN NUTRITION (2022)

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Article Biochemistry & Molecular Biology

The Effect of N-Acetylation on the Anti-Inflammatory Activity of Chitooligosaccharides and Its Potential for Relieving Endotoxemia

Wentong Hao et al.

Summary: This study investigates the effect of degree of acetylation (DA) on the anti-inflammatory activity of chitooligosaccharides (COS). It found that COS with a DA of 12% exhibits the highest anti-inflammatory activity and is able to alleviate the damage caused by endotoxemia, providing a foundation for the development of COS as an anti-endotoxemia drug.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Subcritical Water Enhanced with Deep Eutectic Solvent for Extracting Polysaccharides from Lentinus edodes and Their Antioxidant Activities

Jixian Zhang et al.

Summary: In this study, subcritical water extraction assisted with deep eutectic solvent was used to extract Lentinus edodes polysaccharides, and the antioxidant activity of the polysaccharide samples was investigated. The results showed that the polysaccharides obtained with the SWE-assisted DES method had stronger antioxidant activity, making it a promising approach for various industrial applications.

MOLECULES (2022)

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Article Engineering, Biomedical

Photosensitizer-Polypeptide Conjugate for Effective Elimination of Candida albicans Biofilm

Pengqi Wan et al.

Summary: In this study, a photosensitizer-polypeptide conjugate was synthesized for effective antifungal and antibiofilm treatment. The conjugate showed enhanced binding ability to Candida albicans and fluconazole-resistant Candida albicans through electrostatic interactions. It exhibited effective antifungal efficiency and improved penetration in a Candida albicans biofilm, effectively eliminating the biofilm by photodynamic effects. In a fluconazole-resistant Candida albicans-infected rat model, the conjugate demonstrated significantly enhanced therapeutic effects with minimal side effects.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Biochemistry & Molecular Biology

Chitosan Oligosaccharide Attenuates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction through Suppressing the Inflammatory Response and Oxidative Stress in Mice

Wenjing Tao et al.

Summary: This study demonstrates that chitosan oligosaccharide (COS) has a protective effect against lipopolysaccharide (LPS)-induced intestinal injury. COS improves the mucosal morphology and tight junction protein expressions, increases goblet cells number and mucin expression, up-regulates antimicrobial peptide expressions, decreases pro-inflammatory cytokine production and neutrophil recruitment, and ameliorates intestinal oxidative stress. The beneficial effects of COS on intestinal barrier function are associated with its anti-inflammatory activities and antioxidant capacity.

ANTIOXIDANTS (2022)

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Article Chemistry, Applied

Construction of chitooligosaccharide-based nanoparticles of pH/redox cascade responsive for co-loading cyclosporin A and AZD9291

Shumin Chen et al.

Summary: A chitooligosaccharide-based nanoparticle with enhanced delivery efficiency and endocytosis was constructed in this study, which improved the therapeutic effect of AZD9291 and overcame drug resistance. The surface charge of the nanoparticles changed in the weakly acidic tumor microenvironment and released drugs in the cytoplasm.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Applied

Structural characterization and antioxidant activity of Polygonatum sibiricum polysaccharides

Shiqiang Wang et al.

Summary: Polysaccharides obtained from Polygonatum sibiricum (PSP) were purified and characterized in this study. The PSP1 sample had the highest content and best solubility. The main sugar residue linkages were identified as 1)-beta-D-Fruf-(2 -> 1)-beta-D-Fruf-(2 -> 1), 1 -> -beta-D-Fruf-(2 -> 6)alpha-D-Glcp (1 ->,-> 4)-beta-D-Manp-(1 -> 4)-beta-D-Manp-(1 -> and -> 6)-beta-D-Glcp-(1 -> 4)-beta-D-Manp-(1 ->. Branch chain analysis revealed the presence of -> 1,6)-beta-D-Fruf-(2 ->, beta-D-Fruf-(2 ->,-> 1,6)-beta-D-Fruf-(2 ->,-> 6)-beta-D-Fruf(2 -> linkages, with the link site at position C-6. In vitro antioxidant activity tests showed that PSP1 had scavenging effects on DPPH, hydroxyl radical, superoxide anion radical, and exhibited a specific chelating ability for ferrous ions. These findings suggest that P. sibiricum polysaccharides may possess potential antioxidant properties.

CARBOHYDRATE POLYMERS (2022)

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Article Toxicology

JC-10 probe as a novel method for analyzing the mitochondrial membrane potential and cell stress in whole zebrafish embryos

Nadin Younes et al.

Summary: JC-10 is a sensitive in vivo method for measuring cytotoxicity in zebrafish embryos, with higher sensitivity and specificity compared to common cytotoxicity assays.

TOXICOLOGY RESEARCH (2022)

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Article Thermodynamics

Thermal decomposition mechanism of poly(dimethyldiallylammonium chloride)

Xu Jia et al.

Summary: The thermal decomposition mechanism of PDMDAAC was studied using quantum chemical calculation and experimental methods, revealing that the C-N bond in the cyclic five member ring is the most easily broken bond. The thermal decomposition process occurs in two stages, leading to gas products NH2Cl, CH4, C2H2, and C3H8.

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY (2022)

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Review Microbiology

Candida albicans-The Virulence Factors and Clinical Manifestations of Infection

Jasminka Talapko et al.

Summary: Candida albicans is a common commensal fungus in the human body, which can cause various infections when the balance with the host immune system is disrupted. Factors such as dysbiosis of microbiota, immune dysfunction, and mucosal barrier damage contribute to the transition of C. albicans from a normal flora to a pathogenic state. The presence of C. albicans in the bloodstream can lead to invasive infections.

JOURNAL OF FUNGI (2021)

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Article Chemistry, Medicinal

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

Nayara Sousa da Silva et al.

Summary: The study focused on the enzymatic production, characterization, and in vitro evaluation of the cytotoxic, antibacterial, antifungal, and antiparasitic effects of chitooligosaccharides (COSs) obtained from the hydrolysis of chitosan. NMR and mass spectrometry analyses revealed the presence of a mixture with 81% deacetylated COS and acetylated hexamers. COSs demonstrated no cytotoxicity at concentrations below 2 mg/mL, and showed promising activity against bacteria, yeasts, and exhibited time-dependent parasitic inhibition.

MARINE DRUGS (2021)

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Article Biochemistry & Molecular Biology

A general strategy to synthesis chitosan oligosaccharide-O-Terpenol derivatives with antibacterial properties

Lin Yue et al.

Summary: The present study synthesized a series of chitosan oligosaccharide-O-Terpenol derivatives and evaluated their in vitro antibacterial activity. These derivatives showed excellent solubility and antibacterial activity, with higher sensitivity to Staphylococcus aureus than Escherichia coli, suggesting their potential application as natural antibacterial agents. This study paves the way for expanding the application scope of COS and its derivatives in the food and pharmaceutical industries.

CARBOHYDRATE RESEARCH (2021)

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Review Pharmacology & Pharmacy

Antifungal agents and the kidney: pharmacokinetics, clinical nephrotoxicity, and interactions

Athanasios Tragiannidis et al.

Summary: Invasive fungal infections remain a significant concern for severely ill and immunocompromised patients, leading to an increase in research on antifungal drugs. Nephrotoxicity is an important consideration in the use of antifungal agents, particularly for patients with compromised organ functions or receiving other potentially nephrotoxic medications. Amphotericin B deoxycholate is identified as having the highest potential for nephrotoxicity, followed by lipid formulations of amphotericin B and the antifungal triazoles to a much lesser extent.

EXPERT OPINION ON DRUG SAFETY (2021)

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Article Chemistry, Analytical

Improved detection of reactive oxygen species by DCFH-DA: New insight into self-amplification of fluorescence signal by light irradiation

Daliang Yu et al.

Summary: The study identified factors influencing the detection process of ROS by DCFH-DA and developed a new method with higher stability and sensitivity. A significant increase in fluorescence signal of DCFH-DA solution under light irradiation was observed, leading to the development of a reliable and sensitive ROS detection method. This method successfully detected ROS in HeLa cells induced by H2O2 and plastic nanoparticles, providing new insights into the proportional increase of fluorescence signal under light irradiation.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Review Materials Science, Biomaterials

Amphiphilic polymer therapeutics: an alternative platform in the fight against antibiotic resistant bacteria

Haruko Takahashi et al.

Summary: This review discusses the recent development of polymer therapeutics with antimicrobial activity, focusing on the biomimetic design of synthetic polymers to target bacterial cell membranes based on host-defense peptides. The discussion also extends to the future challenges and opportunities of antimicrobial polymers for clinical applications.

BIOMATERIALS SCIENCE (2021)

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Article Chemistry, Applied

Cinnamyl alcohol modified chitosan oligosaccharide for enhancing antimicrobial activity

Lin Yue et al.

FOOD CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

In vitro and in vivo anticandidal efficacy of green synthesized gold nanoparticles using Spirulina maxima polysaccharide

S. H. S. Dananjaya et al.

PROCESS BIOCHEMISTRY (2020)

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Review Microbiology

Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture

Matthew C. Fisher et al.

MBIO (2020)

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Article Biochemistry & Molecular Biology

Eco-friendly synthesis of an alkyl chitosan derivative

Haroldo C. B. Paula et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Polymer Science

Antibacterial activity of chitosan and its derivatives and their interaction mechanism with bacteria: Current state and perspectives

Jianhui Li et al.

EUROPEAN POLYMER JOURNAL (2020)

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Article Multidisciplinary Sciences

Amelioration of Physical Properties and Printability of Paper Coated with N-methylated Chitosan

Meiyan Wu et al.

SCIENTIFIC REPORTS (2020)

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Article Biochemistry & Molecular Biology

Screening and Matching Amphiphilic Cationic Polymers for Efficient Antibiosis

Shuyue Zhao et al.

BIOMACROMOLECULES (2020)

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Article Polymer Science

Synthesis and characterization of a ROMP-based polycationic antimicrobial hydrogel

Arzu Palantoken et al.

EUROPEAN POLYMER JOURNAL (2019)

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Review Biochemistry & Molecular Biology

Chitosan oligosaccharide (COS): An overview

Muhammad Naveed et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Review Polymer Science

Antimicrobial cationic polymers: from structural design to functional control

Yuchong Yang et al.

POLYMER JOURNAL (2018)

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Article Green & Sustainable Science & Technology

Influence of pKa on solvent performance of MAPA promoted tertiary amines

Ida M. Bernhardsen et al.

INTERNATIONAL JOURNAL OF GREENHOUSE GAS CONTROL (2018)

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Review Chemistry, Multidisciplinary

Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens

Xiaokang Ding et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Agriculture, Multidisciplinary

2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-Oxide (PTIO•) Radical Scavenging: A New and Simple Antioxidant Assay In Vitro

Xican Li

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

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Article Biotechnology & Applied Microbiology

Alginate oligosaccharides modify hyphal infiltration of Candida albicans in an invitro model of invasive human candidosis

M. F. Pritchard et al.

JOURNAL OF APPLIED MICROBIOLOGY (2017)

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Review Microbiology

Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species

Sarah G. Whaley et al.

FRONTIERS IN MICROBIOLOGY (2017)

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Article Chemistry, Applied

Geraniol grafted chitosan oligosaccharide as a potential antibacterial agent

Lin Yue et al.

CARBOHYDRATE POLYMERS (2017)

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Article Chemistry, Medicinal

Does the Use of Chitosan Contribute to Oxalate Kidney Stone Formation?

Moacir Fernandes Queiroz et al.

MARINE DRUGS (2015)

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Article Engineering, Biomedical

Effect of concentration and molecular weight of chitosan and its derivative on the free radical scavenging ability

Huili Li et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2014)

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Article Biochemistry & Molecular Biology

Antimicrobial Poly(methacrylamide) Derivatives Prepared via Aqueous RAFT Polymerization Exhibit Biocidal Efficiency Dependent upon Cation Structure

Lea C. Paslay et al.

BIOMACROMOLECULES (2012)

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Article Biochemistry & Molecular Biology

Superoxide radicals scavenging and xanthine oxidase inhibitory activity of magnesium lithospermate B from Salvia miltiorrhiza

Xiaoyu Liu et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2009)

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Review Biotechnology & Applied Microbiology

Chitosan and its antimicrobial potential - a critical literature survey

Dina Raafat et al.

MICROBIAL BIOTECHNOLOGY (2009)

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Article Biotechnology & Applied Microbiology

Quantifying metabolic activity of filamentous fungi using a colorimetric XTT assay

Bill J. Moss et al.

BIOTECHNOLOGY PROGRESS (2008)

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Article Pharmacology & Pharmacy

Antifungal effect of high- and low-molecular-weight chitosan hydrochloride, carboxymethyl chitosan, chitosan oligosaccharide and N-acetyl-D-glucosamine against Candida albicans, Candida krusei and Candida glabrata

F. Seyfarth et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

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Article Chemistry, Medicinal

Hydroxyl radicals scavenging activity of N-substituted chitosan and quaternized chitosan

Zhanyong Guo et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)

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Article Food Science & Technology

Radical scavenging activity of chitooligosaccharide with different molecular weights

YM Yang et al.

EUROPEAN FOOD RESEARCH AND TECHNOLOGY (2006)

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Article Biochemistry & Molecular Biology

Role of reactive oxygen species (ROS) in apoptosis induction

HU Simon et al.

APOPTOSIS (2000)

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N,N-dimethyl chitosan oligosaccharide (DMCOS) promotes antifungal activity by causing mitochondrial damage

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