Targeting CAFs to Improve Anti-PD-1 Checkpoint Immunotherapy

Article Oncology

Stromal Reprogramming through Dual PDGFRa/b Blockade Boosts the Efficacy of Anti-PD-1 in Fibrotic Tumors

Takahiko Akiyama et al.

Summary: Excess stroma and cancer-associated fibroblasts (CAF) promote cancer progression and immune evasion. The study demonstrates that platelet-derived growth factor C (PDGFC) and D expression are associated with poor prognosis in gastric cancer patients, and PDGF receptor beta (PDGFRI3) is predominantly expressed in diffuse-type gastric cancer stroma. By manipulating the stroma through PDGFRa/I3 blockade, the immunosuppressive microenvironment can be reversed, leading to enhanced efficacy of immune checkpoint inhibitors in fibrotic cancer.

CANCER RESEARCH (2023)

添加到收藏夹

Review Oncology

Lost in translation: Revisiting the use of tyrosine kinase inhibitors in colorectal cancer

Kirti K. Iyer et al.

Summary: Patients with advanced or metastatic colorectal cancer (mCRC) have limited effective treatment options. There is a gap in the translation of targeted therapies to the clinic, highlighting the limitations of preclinical models. Several important questions remain unresolved, including the required intracellular concentrations for anticancer efficacy, the range of intra-tumoral drug concentrations in clinical settings, the involvement of intended targeted kinases in the anti-cancer activity, and the impact of these drugs on the tumor microenvironment. An integrated approach with more sophisticated preclinical models and techniques may improve the prediction of clinical treatment efficacy.

CANCER TREATMENT REVIEWS (2022)

添加到收藏夹

Review Oncology

Overcoming TGFβ-mediated immune evasion in cancer

Daniele V. F. Tauriello et al.

Summary: This review discusses the role of TGF beta in the tumour immune microenvironment and the importance of TGF beta inhibition in restoring cancer immunity. TGF beta controls multiple cell fate decisions during development and tissue homeostasis, and dysregulation of this pathway can lead to various diseases including cancer. The context-dependent functions of TGF beta in the tumour microenvironment play a crucial role in suppressing or promoting cancer.

NATURE REVIEWS CANCER (2022)

添加到收藏夹

Article Oncology

Current treatment and recent progress in gastric cancer

Smita S. Joshi et al.

Summary: Gastric cancer is a common cause of cancer death worldwide, with treatment options including systemic chemotherapy, radiotherapy, surgery, immunotherapy, and targeted therapy. Classification and biomarkers for gastric cancer help in personalized therapy and identifying populations most likely to benefit from immunotherapy and targeted therapy.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Article Oncology

Regorafenib enhances anti-PD1 immunotherapy efficacy in murine colorectal cancers and their combination prevents tumor regrowth

Dennis Doleschel et al.

Summary: The study showed that the combination therapy of REG and aPD1 significantly improved anti-tumor activity in both colorectal cancer models. The synergistic effects of the two drugs induced sustained M1 polarization and durable reduction of Treg cells, leading to a sustained inhibition of colon cancer regrowth. This suggests the potential for clinical evaluation in colorectal cancer, including MSS tumors.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Review Oncology