Understanding Long-Term Survival of Patients with Ovarian Cancer-The Tumor Microenvironment Comes to the Forefront

Article Cell Biology

LRP5 promotes cancer stem cell traits and chemoresistance in colorectal cancer

Xiaobo Nie et al.

Summary: The activation of low-density lipoprotein receptor-related protein 5 (LRP5) promotes cancer stem cell-like phenotypes in colorectal cancer (CRC) cells through activating the canonical Wnt/beta-catenin and IL-6/STAT3 signaling pathways. The upregulation of LRP5 expression is closely associated with clinical stages of CRC patients. Silencing LRP5 gene can suppress the cancer stem cell-like phenotypes of CRC.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Article Oncology

Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner

Jinghai Wu et al.

Summary: This study found that stroma-specific loss of p53 enhances tumorigenesis driven by the oncogene Kras(G12D) in mammary glands. The loss of p53 in the stroma promotes both epithelial and fibroblast proliferation, increases DNA damage and/or replication stress in tumor cells, and decreases apoptosis. Furthermore, it affects the tumor immune landscape and has an impact on patient survival.

MOLECULAR CANCER RESEARCH (2022)

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Article Genetics & Heredity

The genomic and immune landscape of long-term survivors of high-grade serous ovarian cancer

Dale W. Garsed et al.

Summary: This study analyzed the genomic, transcriptomic, and methylomic profiles of patients with advanced-stage HGSC who survived more than 10 years after diagnosis. Long-term survivors had more alterations in DNA repair genes and higher neoantigen load. Patients were clustered into survival groups based on genomic and immune cell signatures, including different subsets of patients with BRCA1 alterations. Specific combinations of genetic and immune factors contribute to long-term survival in HGSC.

NATURE GENETICS (2022)

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Article Oncology