☆ 4.8 Editorial Material

Turning Down Oxygen to Turn Up Inflammation in CAFs

CANCER RESEARCH (2023)

Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell-Derived Cytokines

Simon Schworer et al.

Summary: Cancer-associated fibroblasts (CAF) in pancreatic ductal adenocarcinoma (PDAC) exhibit heterogeneity, with myofi-broblastic CAFs (myCAF) and inflammatory CAFs (iCAF) having opposing roles. In vivo, iCAFs show a hypoxic gene expression profile and are enriched in hypoxic regions of PDAC tumors, while myCAFs are excluded from these areas. Hypoxia induces an inflammatory gene expression signature in fibroblasts and synergizes with cancer cell-derived cytokines to promote the iCAF phenotype. HIF1a stabilization is sufficient to induce the iCAF phenotype and promote PDAC tumor growth.

CANCER RESEARCH (2023)

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Article Gastroenterology & Hepatology

Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment

Carolina J. Garcia Garcia et al.

Summary: In pancreatic ductal adenocarcinoma, stromal HIF2 appears to play a crucial role and represents a druggable target to alleviate tumor microenvironment immunosuppression and enhance immune responses.

GASTROENTEROLOGY (2022)

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Article Oncology

Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer

Ashley M. Mello et al.

Summary: Hypoxia plays a crucial role in promoting the inflammatory phenotype in cancer-associated fibroblasts (CAF) in pancreatic ductal adenocarcinoma (PDAC).

ONCOGENESIS (2022)

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Review Cell Biology

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

Pearl Lee et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Article Oncology

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

Ela Elyada et al.

CANCER DISCOVERY (2019)

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Article Immunology

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Daniel Ohlund et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Review Gastroenterology & Hepatology

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

Mert Erkan et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2012)

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Turning Down Oxygen to Turn Up Inflammation in CAFs

相关参考文献

Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell-Derived Cytokines

Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment

Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

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