Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a metabolic regulator in cytotoxic T lymphocytes in multiple myeloma

Review Cell Biology

The hallmarks of cancer metabolism: Still emerging

Natalya N. Pavlova et al.

Summary: The metabolism of cancer cells is highly adaptable, allowing them to sustain growth and proliferation. This adaptation can also influence the behavior of non-transformed cells in the tumor vicinity.

CELL METABOLISM (2022)

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Article Oncology

Single-cell transcriptome profiling reveals the key role of ZNF683 in natural killer cell exhaustion in multiple myeloma

Xin Li et al.

Summary: Our study reveals that NK cell exhaustion in MM is associated with distinct transcriptomic features, including downregulation of activating receptors and cytolytic molecules and upregulation of inhibitory receptors. We identify ZNF683 as a transcriptional suppressor that directly binds to the promoter of SH2D1B, leading to downregulation of this gene and impaired NK cell cytotoxic activity.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

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Article Immunology

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

Denis A. Mogilenko et al.

Summary: This study characterized age-associated alterations in immune cells across multiple mouse organs and identified a distinct population of age-associated GZMK-expressing CD8(+) T cells. These Taa cells, highly clonal with specific features, were found to be a potential target to address age-associated dysfunctions of the immune system. In humans, proportions of the circulating GZMK(+) CDE3(+) T cell population that shares signatures with mouse Taa cells also increased during healthy aging.

IMMUNITY (2021)

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Review Biochemistry & Molecular Biology

Metabolic Disorders in Multiple Myeloma

Maria Gavriatopoulou et al.

Summary: Multiple myeloma is characterized by monoclonal proliferation of plasma cells in the bone marrow and cancer cells deregulate metabolic pathways to ensure their proliferation, survival, and avoid immune surveillance. Metabolic syndrome, inflammatory cytokines, and the use of metformin and statins have been associated with the incidence and prognosis of MM. Targeting dysregulated pathways in MM may enhance antitumor therapeutics.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

The Role of Tumor Microenvironment in Multiple Myeloma Development and Progression

Almudena Garcia-Ortiz et al.

Summary: Multiple myeloma is a hematologic cancer characterized by clonal proliferation of plasma cells in the bone marrow, with disease progression influenced by the tumor microenvironment created by various cells and soluble factors. Understanding the elements that control the microenvironment could lead to better-targeted therapies for this incurable disease.

CANCERS (2021)

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Article Multidisciplinary Sciences

Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single-cell transcriptomics

Stephan M. Tirier et al.

Summary: Relapsed/refractory multiple myeloma (RRMM) is characterized by a remarkable heterogeneity and high drug resistance. Here, the authors analyse RRMM samples by single-cell RNA-sequencing, revealing molecular features associated with high-risk chromosomal 1q-gain and changes in the tumor microenvironment.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer

Fengying Wu et al.

Summary: This study utilized single-cell RNA sequencing to analyze 42 late-stage NSCLC patients, revealing significant heterogeneity in tumors in terms of cellular composition, chromosomal structure, developmental trajectory, and the identification of rare cell types. The research also highlighted the correlation between tumor heterogeneity and tumor-associated neutrophils.

NATURE COMMUNICATIONS (2021)

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Review Immunology

Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy

Guillermo O. Rangel Rivera et al.

Summary: The review discusses how targeting metabolic pathways can enhance the immune response of T cells to tumors, as tumors consume key metabolites in the host, depriving T cells of essential nutrients for growth and function. Furthermore, immunosuppressive molecules and checkpoint receptors further compromise the activity of T cells within tumors.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape

Madelon M. E. de Jong et al.

Summary: The progression and therapy response of multiple myeloma is influenced by the bone marrow niche. A study identified inflammatory mesenchymal stromal cells that interact with tumor cells, indicating a potential role in disease persistence. Tracking bone marrow inflammation over time revealed a link to disease persistence despite successful antitumor therapy.

NATURE IMMUNOLOGY (2021)

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Review Immunology

CD8+ T Cell Exhaustion in Cancer

Joseph S. Dolina et al.

Summary: Recent research has revealed the heterogeneity within the exhausted CD8(+) T cell lineage, which consists of multiple interconnected subpopulations with distinct characteristics and locations. This understanding calls for a re-focusing of cancer immunotherapies on targeting the driver mechanisms underlying CD8(+) T(ex) development to stabilize functional subsets.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Alterations in the Transcriptional Programs of Myeloma Cells and the Microenvironment during Extramedullary Progression Affect Proliferation and Immune Evasion

Daeun Ryu et al.

CLINICAL CANCER RESEARCH (2020)

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Review Oncology

The microenvironment in myeloma

Oliver C. Lomas et al.

CURRENT OPINION IN ONCOLOGY (2020)

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Review Pharmacology & Pharmacy

Solute carrier transporters: the metabolic gatekeepers of immune cells

Wenxin Song et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Oncology

Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma

L. Ren et al.

CANCER & METABOLISM (2020)

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Article Oncology

Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma

Oksana Zavidij et al.

NATURE CANCER (2020)

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Review Immunology

CD8+ T cell exhaustion

Makoto Kurachi

SEMINARS IN IMMUNOPATHOLOGY (2019)

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Article Multidisciplinary Sciences

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Robert D. Leone et al.

SCIENCE (2019)

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Article Multidisciplinary Sciences

IRE1 alpha-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

Minkyung Song et al.

NATURE (2018)

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Article Multidisciplinary Sciences

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

Lei Zhang et al.

NATURE (2018)

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Article Toxicology

Melatonin suppresses methamphetamine-triggered endoplasmic reticulum stress in C6 cells glioma cell lines

Wanida Tungkum et al.

JOURNAL OF TOXICOLOGICAL SCIENCES (2017)

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Article Biochemical Research Methods

Reversed graph embedding resolves complex single-cell trajectories

Xiaojie Qiu et al.

NATURE METHODS (2017)

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Review Oncology

Multiple Myeloma and the Immune Microenvironment

Yawara Kawano et al.

CURRENT CANCER DRUG TARGETS (2017)

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Review Biochemistry & Molecular Biology

Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer

Juan R. Cubillos-Ruiz et al.

CELL (2017)

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Article Hematology

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Marina Bolzoni et al.

BLOOD (2016)

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Review Biochemistry & Molecular Biology

The untold story of IFN-γ in cancer biology

M. Alper Kursunel et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2016)

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Correction Immunology

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction (vol 45, pg 374, 2016)

Nicole E. Scharping et al.

IMMUNITY (2016)

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Review Immunology

The Unfolded Protein Response in Homeostasis and Modulation of Mammalian Immune Cells

Ana Sofia Martins et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2016)

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Article Oncology

Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study

Alexander M. Lesokhin et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

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Review Oncology

International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma

Shaji Kumar et al.

LANCET ONCOLOGY (2016)

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Article Oncology

Multiple myeloma causes clonal T-cell immunosenescence: identification of potential novel targets for promoting tumour immunity and implications for checkpoint blockade

H. Suen et al.

LEUKEMIA (2016)

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Review Oncology

IRE1 α-XBP1 signaling pathway, a potential therapeutic target in multiple myeloma

Lin Chen et al.

LEUKEMIA RESEARCH (2016)

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Review Immunology

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

Joel Crespo et al.

CURRENT OPINION IN IMMUNOLOGY (2013)

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Article Biochemistry & Molecular Biology

Identification of a Novel Endoplasmic Reticulum Stress Response Element Regulated by XBP1

Michael Misiewicz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Multidisciplinary Sciences

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

E. L. Pearce et al.

SCIENCE (2013)

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Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

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Article Immunology

IFN-α Directly Promotes Programmed Cell Death-1 Transcription and Limits the Duration of T Cell-Mediated Immunity

Seigo Terawaki et al.

JOURNAL OF IMMUNOLOGY (2011)

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Article Immunology

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

Erikka L. Carr et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Geriatrics & Gerontology

KLRG1-more than a marker for T cell senescence

Sian M. Henson et al.

AGE (2009)

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Article Biochemistry & Molecular Biology

Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cells

Altin Gjymishka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Immunology

Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection

Daisuke Kamimura et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Biochemistry & Molecular Biology

XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks

Diego Acosta-Alvear et al.

MOLECULAR CELL (2007)

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Article Biochemistry & Molecular Biology

Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability

Russell Hyde et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

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Review Immunology

Interferons, immunity and cancer immunoediting

Gavin P. Dunn et al.

NATURE REVIEWS IMMUNOLOGY (2006)

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Article Immunology

Direct stimulation of T cells by type IIFN enhances the CD8+ T cell response during cross-priming

Agnes Le Bon et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Physiology

Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family

B Mackenzie et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)

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Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a metabolic regulator in cytotoxic T lymphocytes in multiple myeloma

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