4.7 Article

When N7-methyladenosine modification meets cancer: Emerging frontiers and promising therapeutic opportunities

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Structural basis of regulated m7G tRNA modification by METTL1-WDR4

Jiazhi Li et al.

Summary: Chemical modifications of RNA play a crucial role in various biological processes. N-7-methylguanosine (m(7)G) is essential for the integrity and stability of a large group of tRNAs. The METTL1-WDR4 complex acts as a methyltransferase that modifies G46 in specific tRNAs, and its dysregulation is implicated in tumorigenesis. However, the mechanism of tRNA substrate recognition and regulation of METTL1-WDR4 remains unknown.

NATURE (2023)

Article Multidisciplinary Sciences

Structures and mechanisms of tRNA methylation by METTL1–WDR4

Victor M. Ruiz-Arroyo et al.

NATURE (2023)

Article Gastroenterology & Hepatology

Targeting tumour-intrinsic N7-methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy

Haining Liu et al.

Summary: This study reveals that PMN-MDSCs, enriched in advanced ICCs, are significantly correlated with N-7-methylguanosine tRNA methyltransferase METTL1. METTL1 promotes PMN-MDSC accumulation and ICC progression by regulating translational targets like CXCL8 and Cxcl5. Furthermore, co-blockade of METTL1 and its downstream chemokine pathway enhances the efficacy of anti-PD-1 therapy.
Article Oncology

WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15

Aamir Ali Khan et al.

Summary: The study revealed that WBSCR22 plays a tumor suppressive role in pancreatic cancer by inhibiting cellular proliferation, migration, invasion, and tumor formation. WBSCR22 negatively regulates the transcription of ISG15, leading to its antitumor function, while ISG15 upregulation promotes the malignant characteristics of pancreatic cancer. Additionally, WBSCR22 and TRMT112 synergistically function in pancreatic cancer, and the concurrent overexpression of WBSCR22 and TRMT112 enhances the tumor suppressive potential of WBSCR22.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

Article Oncology

Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression

Jie Chen et al.

Summary: The study revealed that tRNA m(7)G methyltransferase METTL1 promotes the development and malignancy of head and neck squamous cell carcinoma (HNSCC) by regulating global mRNA translation, including the PI3K/AKT/mTOR signaling pathway, and alters the immune landscape.

CANCER COMMUNICATIONS (2022)

Article Biochemistry & Molecular Biology

Identification and Characterization of the Interaction Between the Methyl-7-Gua-nosine Cap Maturation Enzyme RNMT and the Cap-Binding Protein eIF4E

Michael J. Osborne et al.

Summary: The cap-binding protein eIF4E directly binds to the cap-maturation enzyme RNMT, playing a crucial role in RNA metabolism and cap processing.

JOURNAL OF MOLECULAR BIOLOGY (2022)

Article Multidisciplinary Sciences

N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis

Hui Han et al.

Summary: This study reveals the oncogenic function of mis-regulated tRNA modification in esophageal squamous cell carcinoma (ESCC) and suggests that targeting METTL1 and its downstream signaling could be a promising therapeutic strategy for ESCC treatment.

NATURE COMMUNICATIONS (2022)

Article Cell Biology

METTL1 drives tumor progression of bladder cancer via degrading ATF3 mRNA in an m7G-modified miR-760-dependent manner

Haiyun Xie et al.

Summary: The m(7)G modification is found to be present in RNA internal positions and plays a crucial role in the proliferation and metastasis of bladder cancer. METTL1 is shown to promote the processing of miR-760 in an m(7)G-dependent manner and indirectly degrade tumor suppressor ATF3 mRNA.

CELL DEATH DISCOVERY (2022)

Editorial Material Cell Biology

Role of N7-methylguanosine (m7G) in cancer

Yongping Chen et al.

Summary: This article summarizes the importance of m(7)G in cancer suppression and explores potential valuable targets for improving cancer therapy and prognoses based on research on this modification.

TRENDS IN CELL BIOLOGY (2022)

Review Oncology

Novel roles of METTL1/WDR4 in tumor via m7G methylation

Wenli Cheng et al.

Summary: As one of the prevalent posttranscriptional modifications of RNA, N-7-methylguanosine (m(7)G) plays essential roles in RNA processing, metabolism, and function, mainly regulated by the methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4) complex. Emerging evidence suggests that the METTL1/WDR4 complex promoted or inhibited the processes of many tumors, including head and neck, lung, liver, colon, bladder cancer, and teratoma, dependent on close m(7)G methylation modification of tRNA or micro-RNA (miRNA). Therefore, METTL1 and m(7)G modification can be used as biomarkers or potential intervention targets, providing new possibilities for early diagnosis and treatment of tumors. This review will mainly focus on the mechanisms of METTL1/WDR4 via m(7)G in tumorigenesis and the corresponding detection methods.

MOLECULAR THERAPY-ONCOLYTICS (2022)

Article Biochemistry & Molecular Biology

m7G-quant-seq: Quantitative Detection of RNA Internal N7-Methylguanosine

Li-Sheng Zhang et al.

Summary: m7G-quant-seq is a quantitative method for accurately detecting and quantifying internal m7G sites in human cytoplasmic tRNAs. The method converts m7G sites into RNA abasic sites through efficient chemical reduction and mild depurination, and calculates the m7G modification fraction by analyzing the variation patterns during reverse transcription. The study demonstrates that m7G-quant-seq can successfully detect internal m7G sites in human cytoplasmic tRNAs and estimate the corresponding m7G methylation stoichiometry. This method is of great importance for monitoring the change in tRNA m7G methylation levels.

ACS CHEMICAL BIOLOGY (2022)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Cell Biology

The expanding world of tRNA modifications and their disease relevance

Tsutomu Suzuki

Summary: tRNAs undergo heavy post-transcriptional modifications, which play crucial roles in accurate codon recognition and reading frame maintenance during protein synthesis. Recent studies have shown that tRNA modifications can be dynamically altered in response to cellular and environmental stresses, and deficiencies in tRNA modification can lead to mitochondrial diseases, neurological disorders, and cancer.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Oncology

METTL1-m7G-EGFR/EFEMP1 axis promotes the bladder cancer development

Xiaoling Ying et al.

Summary: The study reveals that METTL1 is highly expressed in bladder cancer (BC) and correlates with poor patient prognosis. Silencing METTL1 inhibits proliferation, migration, and invasion of BC cells by altering the expression of certain target genes, such as EGFR/EFEMP1, through m(7)G tRNA modification. Forced expression of EGFR/EFEMP1 partially rescues the effects of METTL1 deletion on BC cells, highlighting the potential therapeutic targets in BC treatment.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Article Oncology

METTL1 promotes hepatocarcinogenesis via m7G tRNA modification-dependent translation control

Zhihang Chen et al.

Summary: The N-7-methylguanosine (m(7)G) modification is a common transfer RNA (tRNA) modification in humans. Elevated levels of METTL1 and WDR4 in hepatocellular carcinoma (HCC) are associated with advanced tumor stages and poor patient survival. Mechanistically, METTL1-mediated tRNA m(7)G modification promotes the translation of target mRNAs with higher frequencies of m(7)G-related codons, providing new insights into the role of misregulated tRNA modifications in liver cancer.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Article Biochemistry & Molecular Biology

N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression

Zihao Dai et al.

Summary: Intrahepatic cholangiocarcinoma (ICC) shows upregulation of N-7-methylguanosine (m(7)G) tRNA modification and its methyltransferase complex components, METTL1 and WDR4, which are associated with poor prognosis. METTL/WDR4 play a critical role in promoting ICC cell survival and progression by selectively regulating the translation of oncogenic transcripts through m(7)G-tRNA-decoded codon-frequency-dependent mechanisms. Studies with overexpression and knockout mouse models demonstrate the crucial oncogenic function of Mettl1-mediated m(7)G tRNA modification in promoting ICC tumorigenesis and progression in vivo.

MOLECULAR CELL (2021)

Editorial Material Biochemistry & Molecular Biology

m7G tRNA modification reveals new secrets in the translational regulation of cancer development

Olga Katsara et al.

MOLECULAR CELL (2021)

Article Biochemistry & Molecular Biology

METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation

Esteban A. Orellana et al.

Summary: The study revealed that METTL1 is frequently overexpressed in cancer, affecting tRNA modification and the cell cycle, promoting oncogenesis. Additionally, it was found that overexpression of a specific tRNA can induce oncogenic transformation.

MOLECULAR CELL (2021)

Article Biotechnology & Applied Microbiology

METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression

Jieyi Ma et al.

Summary: This study found that the expression levels of tRNA N7-methylguanosine (m7G) methyltransferase complex components METTL1 and WDR4 are significantly elevated in human lung cancer samples and negatively associated with patient prognosis. METTL1 promotes lung cancer growth and invasion through regulation of m7G tRNA modifications, and tRNA modifications and codon usage play an essential function in mRNA translation regulation.

MOLECULAR THERAPY (2021)

Article Biochemistry & Molecular Biology

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

Alison Galloway et al.

Summary: The study reveals that RNMT plays a crucial role in T cell activation by regulating ribosome biogenesis, which is essential for cellular metabolic reprogramming, proliferation, and differentiation. RNMT selectively regulates the expression of mRNAs targeted by the (m7)G-cap binding protein LARP1, impacting ribosome synthesis and translation rates.

NUCLEIC ACIDS RESEARCH (2021)

Article Cell Biology

MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

Peng Xia et al.

Summary: The study identified that m7G methyltransferase WDR4 is highly expressed in hepatocellular carcinoma (HCC) and promotes HCC cell proliferation by increasing m7G methylation levels. WDR4 enhances HCC progression by regulating CCNB1 mRNA stability and translation, activating PI3K/AKT, and reducing P53 expression. Additionally, WDR4 was found to play a role in drug resistance and metastasis in HCC.

CELL DEATH & DISEASE (2021)

Article Multidisciplinary Sciences

Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer

Ion John Campeanu et al.

Summary: This study identified a subset of METTL genes that are frequently amplified or up-regulated in various human cancers, particularly METTL1, METTL7B, and NTMT1. Higher expression of METTL1 was associated with high-grade tumors and poor prognosis. Functional studies in tumor cell lines indicate the biological importance of METTL1 in cancer cell growth and survival.

SCIENTIFIC REPORTS (2021)

Review Cell Biology

Mapping the epigenetic modifications of DNA and RNA

Lin-Yong Zhao et al.

PROTEIN & CELL (2020)

Article Neurosciences

WBSCR22 confers cell survival and predicts poor prognosis in glioma

Yajie Chi et al.

BRAIN RESEARCH BULLETIN (2020)

Review Microbiology

Probing the diversity and regulation of tRNA modifications

Satoshi Kimura et al.

CURRENT OPINION IN MICROBIOLOGY (2020)

Review Cell Biology

Regulation and action of interferon-stimulated gene 15 in breast cancer cells

Angeles C. Tecalco-Cruz et al.

HUMAN CELL (2020)

Article Medicine, General & Internal

Head and neck squamous cell carcinoma

Daniel E. Johnson et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

Review Biochemistry & Molecular Biology

The chemical diversity of RNA modifications

R. Jordan Ontiveros et al.

BIOCHEMICAL JOURNAL (2019)

Article Biochemistry & Molecular Biology

Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA

Li-Sheng Zhang et al.

MOLECULAR CELL (2019)

Review Oncology

Effects of pericytes and colon cancer stem cells in the tumor microenvironment

Elsa N. Garza Trevino et al.

CANCER CELL INTERNATIONAL (2019)

Review Medicine, General & Internal

Alteration of Epigenetic Modifiers in Pancreatic Cancer and Its Clinical Implication

Yu-Hsuan Hung et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Article Biochemistry & Molecular Biology

Detection of internal N7-methylguanosine (m7G) RNA modifications by mutational profiling sequencing

Christel Enroth et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemical Research Methods

Nucleotide resolution profiling of m7 G tRNA modification by TRAC-Seq

Shuibin Lin et al.

NATURE PROTOCOLS (2019)

Article Genetics & Heredity

Mutations in WDR4 as a new cause of Galloway-Mowat syndrome

Daniela A. Braun et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2018)

Article Chemistry, Multidisciplinary

AlkAniline-Seq: Profiling of m7G and m3C RNA Modifications at Single Nucleotide Resolution

Virginie Marchand et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Review Biochemistry & Molecular Biology

7-Methylguanosine Modifications in Transfer RNA (tRNA)

Chie Tomikawa

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Multidisciplinary Sciences

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

Jan Mauer et al.

NATURE (2017)

Review Biochemistry & Molecular Biology

Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function

Katherine E. Sloan et al.

RNA BIOLOGY (2017)

Review Urology & Nephrology

Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends

Sebastien Antoni et al.

EUROPEAN UROLOGY (2017)

Review Medicine, General & Internal

Lung cancer: current therapies and new targeted treatments

Fred R. Hirsch et al.

LANCET (2017)

Review Genetics & Heredity

Detecting RNA modifications in the epitranscriptome: predict and validate

Mark Helm et al.

NATURE REVIEWS GENETICS (2017)

Review Oncology

Acute myeloid leukemia: a comprehensive review and 2016 update

I. De Kouchkovsky et al.

BLOOD CANCER JOURNAL (2016)

Article Genetics & Heredity

What Do You Mean, Epigenetic?

Carrie Deans et al.

GENETICS (2015)

Article Biochemical Research Methods

Efficient and quantitative high-throughput tRNA sequencing

Guanqun Zheng et al.

NATURE METHODS (2015)

Article Biochemical Research Methods

Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome

Bastian Linder et al.

NATURE METHODS (2015)

Review Multidisciplinary Sciences

Discovery of m7G-cap in eukaryotic mRNAs

Yasuhiro Furuichi

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2015)

Article Genetics & Heredity

What Do You Mean, Epigenetic?

Carrie Deans et al.

GENETICS (2015)

Article Biotechnology & Applied Microbiology

Mutation in WDR4 impairs tRNA m7G46 methylation and causes a distinct form of microcephalic primordial dwarfism

Ranad Shaheen et al.

GENOME BIOLOGY (2015)

Article Biochemistry & Molecular Biology

The Methyltransferase WBSCR22/Merm1 Enhances Glucocorticoid Receptor Function and Is Regulated in Lung Inflammation and Cancer

Maryam Jangani et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Chemistry, Multidisciplinary

Structure and Function of Noncanonical Nucleobases

Thomas Carell et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Article Biochemistry & Molecular Biology

Human RNA Methyltransferase BCDIN3D Regulates MicroRNA Processing

Blerta Xhemalce et al.

Article Biochemistry & Molecular Biology

Trm112 Is Required for Bud23-Mediated Methylation of the 18S rRNA at Position G1575

Sabine Figaro et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Article Medicine, General & Internal

Hepatocellular carcinoma

Alejandro Forner et al.

LANCET (2012)

Article Biochemistry & Molecular Biology

RAM/Fam103a1 Is Required for mRNA Cap Methylation

Thomas Gonatopoulos-Pournatzis et al.

MOLECULAR CELL (2011)

Article Immunology

ChIP-Seq: technical considerations for obtaining high-quality data

Benjamin L. Kidder et al.

NATURE IMMUNOLOGY (2011)

Review Biochemical Research Methods

Computational methods for transcriptome annotation and quantification using RNA-seq

Manuel Garber et al.

NATURE METHODS (2011)

Review Genetics & Heredity

Principles and challenges of genome-wide DNA methylation analysis

Peter W. Laird

NATURE REVIEWS GENETICS (2010)

Review Biochemistry & Molecular Biology

MicroRNAs: Target Recognition and Regulatory Functions

David P. Bartel

Article Biochemistry & Molecular Biology

Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of Pre-40S subunits

Joshua White et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Structure of the yeast tRNA m7G methylation complex

Nicolas Leulliot et al.

STRUCTURE (2008)

Article Gastroenterology & Hepatology

Advances in prevention and diagnosis of hepatocellular carcinoma

Hans Christian Spangenberg et al.

Expert Review of Gastroenterology & Hepatology (2008)

Article Biochemistry & Molecular Biology

The chemical stability of abasic RNA compared to abasic DNA

Pascal A. Kuepfer et al.

NUCLEIC ACIDS RESEARCH (2007)