期刊
CANCER LETTERS
卷 567, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2023.216283
关键词
PTPRO; Tyrosine phosphatase; MET; Esophageal squamous cell carcinoma; Metastasis
类别
This study demonstrates that protein tyrosine phosphatase receptor-type O (PTPRO) can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO inhibits MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. PTPROlow/p-METhigh can serve as an independent prognostic factor for patients with ESCC.
Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPROlow/ p-METhigh had significantly poor prognosis, suggesting that PTPROlow/p-METhigh can serve as an independent prognostic factor for patients with ESCC.
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