Ewing sarcoma treatment: a gene therapy approach

Ewing sarcoma (ES) is an aggressive malignant tumor, characterized by non-random chromosomal translocations that produce fusion genes. Fusion genes and fusion protein products are promising targets for gene therapy. Therapeutic approaches and strategies vary based on target molecules (nucleotides, proteins) of interest. We present an extensive literature review of active molecules for gene therapy and methods of gene therapy delivery, both of which are necessary for successful treatment.

Automated summary

Ewing sarcoma is an aggressive malignancy characterized by specific chromosomal translocations that result in fusion genes. These fusion genes and their protein products hold promise as targets for gene therapy. In this review, we discuss the active molecules and delivery methods utilized in gene therapy, both of which are essential for effective treatment.