4.7 Article

Oxaliplatin related lncRNAs prognostic models predict the prognosis of patients given oxaliplatin-based chemotherapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Neoadjuvant therapy with immune checkpoint blockade, antiangiogenesis, and chemotherapy for locally advanced gastric cancer

Song Li et al.

Summary: The combination of immune checkpoint inhibitors, antiangiogenesis agents, and chemotherapy showed activity in the neoadjuvant/conversion treatment of cT4a/bN+ gastric cancer. Pathological responses correlated with microsatellite instability status, PD-L1 expression, and tumor mutational burden. Further validation in large randomized trials is warranted.

NATURE COMMUNICATIONS (2023)

Article Cell Biology

Construction of a Necroptosis-Related lncRNA Signature for Predicting Prognosis and Immune Response in Kidney Renal Clear Cell Carcinoma

Yue Zhang et al.

Summary: In this study, we identified 6 necroptosis-related lncRNAs (NRLs) and constructed a risk model for kidney renal clear cell carcinoma (KIRC) patients. The risk score based on these NRLs can independently predict the prognosis of KIRC patients and provide a promising method to predict immune response. Our findings contribute to further research on NRLs and KIRC as well as the development of therapeutic drugs.
Article Gastroenterology & Hepatology

Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX , or chemoradiotherapy in patients with borderline resectable pancreatic cancer (ESPAC5): a four-arm, multicentre, randomised, phase 2 trial

Paula Ghaneh et al.

Summary: The study compared the feasibility and efficacy of three different types of short-course neoadjuvant therapy with immediate surgery. The findings showed that neoadjuvant chemotherapy significantly prolonged survival, with gemcitabine plus capecitabine or FOLFIRINOX regimen demonstrating the best results.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2023)

Article Biochemistry & Molecular Biology

The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity

Jinguan Lin et al.

Summary: The POU2F1-ALDOA axis promotes the progression and oxaliplatin resistance by enhancing metabolic reprogramming in colon cancer.

ONCOGENE (2022)

Article Medicine, Research & Experimental

KHDRBS3 promotes paclitaxel resistance and induces glycolysis through modulated MIR17HG/CLDN6 signaling in epithelial ovarian cancer

Xin Wu et al.

Summary: This study investigates the role of KHDRBS3 in glycolysis and increased resistance to Paclitaxel (PTX) in epithelial ovarian cancer (EOC). The results reveal a KHDRBS3-MIR17HG-CLDN6 regulatory axis that contributes to enhanced glycolysis in EOC and represents a potential target for therapy.

LIFE SCIENCES (2022)

Article Immunology

Integrated analysis of necroptosis-related genes for evaluating immune infiltration and colon cancer prognosis

Wei Yang et al.

Summary: This study constructed a prognostic model for colorectal cancer based on necroptosis-related genes. The model accurately predicted the survival rate of colorectal cancer patients and identified relevant biological processes, pathways, and potential therapeutic targets.

FRONTIERS IN IMMUNOLOGY (2022)

Article Oncology

DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy

Julie Dardare et al.

Summary: This study investigates the role of DDB2 in pancreatic ductal adenocarcinoma (PDAC). The results show that lower expression of DDB2 is associated with shorter disease-free survival in PDAC patients. Overexpression of DDB2 can decrease cell migration and invasion, and increase sensitivity to certain chemotherapy drugs.

FRONTIERS IN ONCOLOGY (2022)

Article Oncology

Silenced LINC01134 Enhances Oxaliplatin Sensitivity by Facilitating Ferroptosis Through GPX4 in Hepatocarcinoma

Xiaofeng Kang et al.

Summary: In this study, LINC01134/Nrf2/GPX4 was identified as a critical axis regulating HCC growth and progression. LINC01134 was found to be closely associated with GPX4 and poor clinical prognosis. Silencing LINC01134 enhanced OXA sensitivity and affected cell death by modulating ROS, lipid peroxidation, and MDA levels. Clinically, LINC01134 was positively correlated with GPX4 and Nrf2, highlighting the importance of this axis in OXA resistance of HCC.

FRONTIERS IN ONCOLOGY (2022)

Article Oncology

Determination of a DNA repair-related gene signature with potential implications for prognosis and therapeutic response in pancreatic adenocarcinoma

Jinzhi Lai et al.

Summary: In this study, a DNA repair-related gene signature was developed and validated to predict prognosis and drug sensitivity in patients with pancreatic adenocarcinoma (PAAD). The signature has the potential to guide personalized treatment.

FRONTIERS IN ONCOLOGY (2022)

Article Chemistry, Medicinal

Construction and Validation of an Oxaliplatin-Resistant Gene Signature in Colorectal Cancer Patients Who Underwent Chemotherapy

Yixin Yin et al.

Summary: This study identified genes associated with oxaliplatin-based chemotherapy resistance in colorectal cancer patients and established a gene signature that effectively predicted patient prognosis. The prognostic value of the gene signature was validated in independent cohorts and cell line experiments.

PHARMACEUTICALS (2022)

Review Pharmacology & Pharmacy

Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: From prediction to druggability

Giasemi C. Eptaminitaki et al.

Summary: This review discusses the current state of research on lncRNAs as regulators and predictors of drug resistance in tumors, emphasizing lncRNA patterns associated with cancer stemness, specific drug classes, and common underlying mechanisms of action. The review also reveals cutting-edge strategies for lncRNA modulation and the current progress on lncRNA-targeting molecules designed to overcome cancer resistance.

DRUG RESISTANCE UPDATES (2022)

Review Cell Biology

Gene regulation by long non-coding RNAs and its biological functions

Luisa Statello et al.

Summary: Recent studies have shed new light on the biogenesis and functions of long non-coding RNAs (lncRNAs), showcasing their diverse roles in gene regulation and signaling pathways, particularly in the contexts of neuronal disorders, immune responses, and cancer. The discovery of unique biogenesis pathways and subcellular localizations of lncRNAs has opened up potential therapeutic avenues for targeting lncRNAs in various biological and pathophysiological conditions.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Multidisciplinary Sciences

LINC00963/miR-4458 regulates the effect of oxaliplatin in gastric cancer by mediating autophagic flux through targeting of ATG16L1

Meng Hou et al.

Summary: The study suggests that LINC00963 and miR-4458 may serve as potential biomarkers for predicting the overall survival of gastric cancer patients. Inhibiting LINC00963 to reduce autophagic flux can increase the sensitivity of gastric cancer cells to oxaliplatin, providing a potential novel therapeutic target for improving oxaliplatin sensitivity.

SCIENTIFIC REPORTS (2021)

Article Cell Biology

LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome

Guozhen Wang et al.

Summary: Extracellular vesicles play a role in releasing HMGB1 in lipopolysaccharide-induced acute liver injuries, contributing to hepatocyte inflammation through the regulation of NLRP3 inflammasomes.

CELL DEATH DISCOVERY (2021)

Article Oncology

Characterization of a ferroptosis and iron-metabolism related lncRNA signature in lung adenocarcinoma

Jie Yao et al.

Summary: A 7-FIRLs signature was established to assess the overall survival of LUAD patients, showing good predictive performance in both the TCGA training set and GEO validation set. This signature proved to be an independent prognostic factor for overall survival, with implications for clinical prediction and immunotherapeutic responses in LUAD patients.

CANCER CELL INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit

Senlin Zhao et al.

Summary: The study shows that MIR17HG, a lactate-responsive lncRNA, promotes colorectal cancer liver metastasis through a glycolysis-mediated positive feedback loop, potentially serving as a novel biomarker and therapeutic target for CRLM.

ONCOGENE (2021)

Article Pharmacology & Pharmacy

L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neurotoxicity

Yaodong Yi et al.

Summary: OCT2, OCTN1, and OCTN2 are involved in the uptake of OXA in dorsal root ganglion and mitochondria. L-THP alleviates OXA-induced peripheral neurotoxicity by inhibiting OXA uptake without impairing its antitumor efficacy. L-THP may be a potential candidate drug for reducing OXA-induced peripheral neurotoxicity.

TOXICOLOGY (2021)

Article Biotechnology & Applied Microbiology

FXYD6 Regulates Chemosensitivity by Mediating the Expression of Na plus /K plus -ATPase α1 and Affecting Cell Autophagy and Apoptosis in Colorectal Cancer

Wen Luo et al.

Summary: This study identified that FXYD6 is downregulated in chemoresistant CRC patients and affects chemosensitivity by mediating the expression of Na+/K+-ATPase alpha 1, influencing cell autophagy and apoptosis. FXYD6 functions as a chemosensitivity regulator, potentially predicting the efficacy of chemotherapy in colorectal cancer.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Genetics & Heredity

Identification of a Hypoxia-Associated Signature for Lung Adenocarcinoma

Zhuomao Mo et al.

FRONTIERS IN GENETICS (2020)

Review Oncology

Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers

Le Zhang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Article Cell & Tissue Engineering

Long Non-Coding RNA LINC00525 Promotes the Stemness and Chemoresistance of Colorectal Cancer by Targeting miR-507/ELK3 Axis

Shunsheng Wang et al.

INTERNATIONAL JOURNAL OF STEM CELLS (2019)

Article Biochemistry & Molecular Biology

Tissue Expression Difference between mRNAs and lncRNAs

Lei Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Oncology

Tumor-Related Molecular Mechanisms of Oxaliplatin Resistance

Eva Martinez-Balibrea et al.

MOLECULAR CANCER THERAPEUTICS (2015)