No rest for the wicked: Tumor cell senescence reshapes the immune microenvironment

Senescence induces key phenotypic changes that can modulate immune responses. Four recent publications in Cancer Discovery, Nature, and Nature Cancer highlight how senescent cells (aged normal or chemotherapy-treated cells) express antigen presentation machinery, present antigens, and interact with T cells and dendritic cells to robustly activate the immune system and promote anti-tumor immunity.

Automated summary

Senescence triggers significant phenotypic changes that can impact immune responses. Recent publications in Cancer Discovery, Nature, and Nature Cancer demonstrate that senescent cells, including those resulting from aging or chemotherapy, express antigen presentation machinery, present antigens, and positively engage with T cells and dendritic cells, ultimately enhancing immune activation and anti-tumor immunity.