T cell dynamism and immune-related adverse events

Immune-related adverse events (irAEs) are a major complication of immune checkpoint inhibitors (ICIs) and occur in an unpredictable fashion. In a Med article, Nunez et al. profile peripheral blood markers in patients treated with ICIs, identifying that dynamic changes in proliferating T cells and cytokine upregulation are associated with irAEs.

Automated summary

Immune-related adverse events (irAEs) are a common complication of immune checkpoint inhibitors (ICIs) and occur unpredictably. In a study published in Med, Nunez et al. analyzed peripheral blood markers in patients treated with ICIs and found that dynamic changes in proliferating T cells and upregulation of cytokines are associated with irAEs.