4.8 Article

Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-? activation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps

Jose M. Adrover et al.

Summary: Neutrophils are key players in the immune system, involved in pathogen eradication and cancer progression. Cancer cells manipulate neutrophil biology, including the formation of neutrophil extracellular traps (NETs), to their advantage. This article discusses how cancer stimulates NET formation and how NETs contribute to disease progression. It also explores the link between neutrophils, NETs, vascular dysfunction, thrombosis, and increased cardiovascular risk in cancer patients. Therapeutic strategies targeting NETs in clinical settings are proposed.

CANCER CELL (2023)

Article Multidisciplinary Sciences

Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications

Xiang Xia et al.

Summary: Postoperative abdominal infectious complications are associated with metastasis in gastric cancer, and the release of neutrophil extracellular traps (NETs) by neutrophils can facilitate the extravasation and metastasis formation of gastric cancer cells.

NATURE COMMUNICATIONS (2022)

Article Medicine, Research & Experimental

Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2

Jose M. Adrover et al.

Summary: Severe acute lung injury, characterized by high mortality and limited treatment options, can be improved with the use of disulfiram, an FDA-approved drug for alcohol use disorder. Disulfiram reduces neutrophil extracellular traps (NETs), improves survival and lung function in a mouse model of transfusion-related acute lung injury, and shows potential benefits in reducing NETs and inflammation in SARS-CoV-2-infected hamsters.

JCI INSIGHT (2022)

Article Oncology

Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization

Emma Nolan et al.

Summary: The study demonstrates a pro-tumorigenic activity of neutrophils in the context of radiotherapy. Activated neutrophils enhance tumor cell growth in the lung by promoting regenerative Notch signaling. Additionally, radiation exposure enhances the stemness phenotype of arriving cancer cells. Blocking neutrophil-dependent Notch activation significantly offsets radiation-enhanced metastases.

NATURE CANCER (2022)

Article Cell Biology

Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy

Qisheng Lin et al.

Summary: This study elucidated a novel mechanism in which NLRP3 inflammasome inhibition attenuated apoptosis and upregulated HIF1A and BNIP3-mediated mitophagy in CI-AKI, indicating the potential applications of MCC950 and roxadustat in clinical CI-AKI treatment.

AUTOPHAGY (2021)

Article Oncology

Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation

Yansen Xiao et al.

Summary: The study reveals that tumor-secreted protease CTSC promotes breast-to-lung metastasis by regulating recruitment of neutrophils and formation of neutrophil extracellular traps.

CANCER CELL (2021)

Article Medicine, Research & Experimental

Neutrophil extracellular traps promote gastric cancer metastasis by inducing epithelial-mesenchymal transition

Tong Zhu et al.

Summary: Neutrophil extracellular traps (NETs) in gastric cancer (GC) are associated with tumor progression, metastasis risk, and tumor microenvironment. The study found that NETs formation is affected by the tumor microenvironment and may exacerbate GC progression through promoting epithelial-mesenchymal transition (EMT). Hence, targeting NETs may be therapeutically beneficial in GC treatment.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

Article Cell Biology

Neutrophil extracellular DNA traps promote pancreatic cancer cells migration and invasion by activating EGFR/ERK pathway

Wei Jin et al.

Summary: NETs play important roles in the progression of pancreatic cancer, promoting migration, invasion, and epithelial-mesenchymal transition of cancer cells through the IL-1 beta/EGFR/ERK pathway. Targeting NETs may provide promising therapeutic strategies for pancreatic cancer.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Multidisciplinary Sciences

Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer

Surashri Shinde-Jadhav et al.

Summary: Radioresistance in bladder cancer treatment is linked to the recruitment of neutrophil extracellular traps (NETs) to the tumor immune microenvironment post-radiation therapy, as demonstrated in a mouse model. Inhibition of NETs can improve radiation response, suggesting NETs as a potential therapeutic target to enhance radiation efficacy.

NATURE COMMUNICATIONS (2021)

Review Oncology

Therapeutic Targeting of the Tumor Microenvironment

Leire Bejarano et al.

Summary: This review provides a comprehensive analysis of the current therapies targeting the TME, combining a discussion of the underlying basic biology with clinical evaluation of different therapeutic approaches, and highlighting the challenges and future perspectives.

CANCER DISCOVERY (2021)

Review Immunology

Connecting the dots: Neutrophils at the interface of tissue regeneration and cancer

Emma Nolan et al.

Summary: Research on neutrophils has expanded rapidly in recent decades, with a focus on their multifaceted functions in immunity, cancer, and tissue repair. Neutrophils are not only involved in tissue defense and repair, but also play key roles in cancer development.

SEMINARS IN IMMUNOLOGY (2021)

Article Immunology

Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis

Laura Pandolfi et al.

Summary: This study found that NETs play a role in inducing epithelial-mesenchymal transition of lung epithelial cells after severe SARS-CoV2 infection. Analysis of samples from severe COVID-19 patients showed high concentrations of NETs correlated with neutrophil count, indicating their potential involvement in disease progression. In vitro models revealed that induction of NETosis by SARS-CoV2 and secretion of AM factors are necessary to trigger a complete EMT expression pattern, shedding light on a possible mechanism for lung fibrosis post-SARS-CoV2 infection.

FRONTIERS IN IMMUNOLOGY (2021)

Review Oncology

Chemoresistance and Metastasis in Breast Cancer Molecular Mechanisms and Novel Clinical Strategies

Jun Cao et al.

Summary: Breast cancer is the most common malignant tumor in females worldwide, and chemotherapy is the standard treatment. However, chemoresistance is a common issue with metastatic breast cancer, and the mechanisms underlying chemoresistance and metastasis have not been fully explored. Possible molecular mechanisms of chemoresistance include efflux transporters, signaling pathways, non-coding RNAs, and cancer stem cells. Novel clinical strategies like drug carriers, immunotherapy, and autophagy regulation are being researched to overcome this challenge.

FRONTIERS IN ONCOLOGY (2021)

Review Biotechnology & Applied Microbiology

Neutrophils as emerging therapeutic targets

Tamas Nemeth et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Multidisciplinary Sciences

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

Linbin Yang et al.

NATURE (2020)

Review Immunology

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

Maria Teresa Masucci et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Biochemistry & Molecular Biology

The updated landscape of tumor microenvironment and drug repurposing

Ming-Zhu Jin et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Oncology

Neutrophil diversity and plasticity in tumour progression and therapy

Sebastien Jaillon et al.

NATURE REVIEWS CANCER (2020)

Review Immunology

Neutrophil Degranulation, Plasticity, and Cancer Metastasis

Faustino Mollinedo

TRENDS IN IMMUNOLOGY (2019)

Review Immunology

Transforming Growth Factor-β Signaling in Immunity and Cancer

Eduard Batlle et al.

IMMUNITY (2019)

Review Oncology

Interaction of tumor-associated macrophages and cancer chemotherapy

Irina Larionova et al.

ONCOIMMUNOLOGY (2019)

Review Immunology

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

Florian R. Greten et al.

IMMUNITY (2019)

Article Immunology

Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum

WonJae Lee et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Hematology

Novel Role of IL (Interleukin)-1β in Neutrophil Extracellular Trap Formation and Abdominal Aortic Aneurysms

Akshaya K. Meher et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

Review Oncology

EMT in cancer

Thomas Brabletz et al.

NATURE REVIEWS CANCER (2018)

Review Immunology

Neutrophil extracellular traps in immunity and disease

Venizelos Papayannopoulos

NATURE REVIEWS IMMUNOLOGY (2018)

Article Oncology

Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies

Daniela F. Quail et al.

CLINICAL CANCER RESEARCH (2017)

Article Biochemistry & Molecular Biology

Neutrophil extracellular traps can serve as platforms for processing and activation of IL-1 family cytokines

Danielle M. Clancy et al.

FEBS JOURNAL (2017)

Article Urology & Nephrology

Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI

Daigo Nakazawa et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Review Biochemistry & Molecular Biology

An emerging role for neutrophil extracellular traps in noninfectious disease

Selina K. Jorch et al.

NATURE MEDICINE (2017)

Review Pharmacology & Pharmacy

The Different Mechanisms of Cancer Drug Resistance: A Brief Review

Behzad Mansoori et al.

ADVANCED PHARMACEUTICAL BULLETIN (2017)

Review Urology & Nephrology

Of Inflammasomes and Alarmins: IL-1β and IL-1α in Kidney Disease

Hans-Joachim Anders

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Article Biochemistry & Molecular Biology

ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization

Guangchuang Yu et al.

MOLECULAR BIOSYSTEMS (2016)

Article Cell Biology

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

Juwon Park et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Article Multidisciplinary Sciences

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

Alexandra Avgustinova et al.

NATURE COMMUNICATIONS (2016)

Article Oncology

Macrophages and Therapeutic Resistance in Cancer

Brian Ruffell et al.

CANCER CELL (2015)

Article Cell Biology

The αvβ1 integrin plays a critical in vivo role in tissue fibrosis

Nilgun I. Reed et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Review Cell Biology

Microenvironmental regulation of therapeutic response in cancer

Florian Klemm et al.

TRENDS IN CELL BIOLOGY (2015)

Review Biotechnology & Applied Microbiology

Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis

Dinesh Vyas et al.

ONCOTARGETS AND THERAPY (2014)

Review Cell Biology

Inflammasomes in cancer: a double-edged sword

Ryan Kolb et al.

PROTEIN & CELL (2014)

Article Oncology

NF-κB, an Active Player in Human Cancers

Yifeng Xia et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Review Biochemistry & Molecular Biology

Microenvironmental regulation of tumor progression and metastasis

Daniela F. Quail et al.

NATURE MEDICINE (2013)

Article Biochemistry & Molecular Biology

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

Swarnali Acharyya et al.

Review Biotechnology & Applied Microbiology

Targeting the TGFβ signalling pathway in disease

Rosemary J. Akhurst et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Cell Biology

Cross Talk among TGF-β Signaling Pathways, Integrins, and the Extracellular Matrix

John S. Munger et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Review Food Science & Technology

Mechanisms of Cisplatin Nephrotoxicity

Ronald P. Miller et al.

TOXINS (2010)

Article Cell Biology

Chemotherapy induces ATP release from tumor cells

Isabelle Martins et al.

CELL CYCLE (2009)

Review Biochemistry & Molecular Biology

The role of proteases in transforming growth factor-beta activation

Gisli Jenkins

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)

Article Cell Biology

Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice

Jean M. Daley et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2008)

Review Immunology

Neutrophil serine proteases: specific regulators of inflammation

Christine T. N. Pham

NATURE REVIEWS IMMUNOLOGY (2006)

Review Oncology

Breast cancer metastasis: Markers and models

B Weigelt et al.

NATURE REVIEWS CANCER (2005)

Article Multidisciplinary Sciences

Neutrophil extracellular traps kill bacteria

V Brinkmann et al.

SCIENCE (2004)