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Article
Medicine, General & Internal
Jeremy Smith et al.
Summary: This study identified factors associated with testing positive for SARS-CoV-2, including race, diabetes, and dementia. The results showed that Black veterans, those with diabetes or dementia, and those living in nursing homes or high-poverty areas were at the highest risk of infection, while veterans living in counties with better adherence to public health guidelines had the lowest risk.
Article
Medicine, General & Internal
Shuko Nojiri et al.
Summary: This study investigated the association between mortality and medical factors and prescription records in Japan in 2020. The results showed that age, sex, Parkinson's disease, cerebrovascular diseases, and chronic kidney diseases were risk factors for mortality. The COVID-19 mortality risk tool proposed in this study can support decision-making and resource utilization.
Article
Neurosciences
Karel Kostev et al.
Summary: This study investigated the association between dementia and mortality in COVID-19 inpatients in Germany. The results showed that although dementia was associated with COVID-19 mortality, the association was weaker than in previously published studies. Further research is needed to better understand the impact of pre-existing neuropsychiatric conditions such as dementia on the course and outcome of COVID-19.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Medicine, General & Internal
Robert J. Ellis et al.
Summary: This retrospective cohort study aimed to identify characteristics associated with hospitalization and death of people with COVID-19 in residential aged care facilities (RACFs). The study found that age and gender were associated with increased likelihood of hospitalization and death. Diseases such as dementia, heart failure, chronic kidney disease, and asthma also increased the risk of hospitalization. Receiving three doses of the COVID-19 vaccine was associated with a lower likelihood of hospitalization or death.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Editorial Material
Medicine, General & Internal
Wafaa M. M. El-Sadr et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Clinical Neurology
Juraj Secnik et al.
Summary: This study investigates the associations between dementia, medication use, and mortality in patients with COVID-19. The study finds that dementia is independently associated with higher in-hospital and overall mortality among COVID-19 patients. Furthermore, the use of antipsychotic medication is associated with an increased risk of mortality.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Geriatrics & Gerontology
Kondwani Joseph Banda et al.
Summary: Oropharyngeal dysphagia (OD) is a common health issue in older adults, associated with risks of pneumonia, malnutrition, and mortality. Early identification and management of OD are crucial for preventing adverse health outcomes in this population.
Article
Immunology
Yun Lu et al.
Summary: This study evaluated the death risk factors of nursing home residents during the prevaccine pandemic period of COVID-19. The study found that increasing age was consistently associated with COVID-19 deaths. Racial/ethnic minorities had similarly high risks of COVID-19 deaths in nursing homes compared to whites. Ownership type and low health inspection ratings of nursing facilities were associated with higher death risk. Individual characteristics such as gender, end-stage renal disease, cognitive impairment, and immunocompromised status were also identified as risk factors for death. However, these individual-level characteristics were less predictive of death compared to the general population.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Geriatrics & Gerontology
Jiyu Kim et al.
Summary: This study investigated the risk factors and outcomes of COVID-19 in community-living older adults. It found that advanced age, gender, race-ethnicity, comorbidities, and biomarkers were associated with COVID-19 hospitalization and severe outcomes. Future research should focus on the impact of frailty and dementia in community-living older adults with severe COVID-19 outcomes.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Geriatrics & Gerontology
Jose-Manuel Ramos-Rincon et al.
Summary: The study found that LTCF residents were older, more often female, had more severe functional dependence, more comorbidities, and were more likely to have dementia compared to community-dwelling patients. Risk factors for mortality in LTCF residents included severe functional dependence, dyspnea, low oxygen saturation, fever, high qSOFA index, bilateral infiltrates, and high C-reactive protein levels. The lower adjusted mortality rate in LTCF residents may be due to earlier identification, treatment, and hospitalization for COVID-19.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Clinical Neurology
Mingchao Shi et al.
Summary: This review article summarizes recent studies showing that molecular and cellular alterations involving T cells, B cells, and immune mediators of adaptive immune occur not only in the peripheral blood but also in the brain and cerebrospinal fluid of AD patients and animal models. Risk factors for AD contribute to disease progression by affecting adaptive immunity, indicating a pivotal role for adaptive immunity in AD. This suggests a potential basis for applying immunotherapy in AD and raises questions about the efficacy and potential off-target effects of such therapies.
Article
Immunology
Marco De Zuani et al.
Summary: Analysis of blood immune cell subsets in severe COVID-19 patients revealed that a low CD4-to-CD8 T cell ratio upon admission was a strong predictor of in-ICU mortality, suggesting it could be used as an early marker for identifying patients who may need enhanced monitoring or proactive intervention in the ICU.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Clinical Neurology
Uxue Lazcano et al.
Summary: This study aimed to investigate the association between previous stroke and mortality after COVID-19 infection. The results showed that previous stroke was associated with a higher mortality in individuals younger than 80 years, including both ischemic and hemorrhagic stroke but not transient ischemic attack.
Article
Geriatrics & Gerontology
Laura Soldevila et al.
Summary: This study analyzed the risk factors for Covid-19 infection and mortality in long-term care nursing home residents aged 65 years and older. The results showed that facility size and community infection rate were important factors for infection risk, while gender, age, and community infection rate were the main predictors of mortality. Additionally, low level of functional dependence, complex chronic condition, and dementia were also associated with increased risk of death. The study findings reveal a complex interplay between structural and individual factors in the transmission and impact of Covid-19 in nursing home settings.
Review
Respiratory System
Vanesa Bellou et al.
Summary: This study conducted a systematic review and meta-analysis to investigate the prognostic factors for COVID-19 patients. The results indicated that factors such as angiotensin-converting enzyme inhibitors, obstructive sleep apnoea, and pharyngalgia were associated with at least one adverse outcome. However, there were some issues identified in the risk of bias assessment.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Geriatrics & Gerontology
Noel Roig-Marin et al.
Summary: This study found that the out-of-hospital mortality of elderly patients with dementia and COVID-19 is significantly higher than those without dementia, while the in-hospital mortality is the opposite. Therefore, the importance of post-discharge care for elderly patients with dementia should be emphasized.
EXPERIMENTAL AGING RESEARCH
(2022)
Article
Infectious Diseases
Ousseny Zerbo et al.
Summary: Among approximately 4.6 million members of Kaiser Permanente Northern California, associations of severe COVID-19 with age, race, and specific comorbidities were examined. Black individuals, Hispanic ethnicity, and those with Alzheimer's disease had higher risks of hospitalization, ICU admission, and death.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2022)
Article
Medicine, General & Internal
Carmela Maniero et al.
Summary: The study described a cohort of older adults admitted to an inner-city London hospital during the first peak of the pandemic, detailing their clinical presentation, comorbidities, and outcomes. The results showed a high mortality rate among these older patients, with survivors requiring increased dependency and greater social care support.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Geriatrics & Gerontology
Roger Wong et al.
Summary: This study aimed to examine the association between dementia and COVID-19 risk and adherence to COVID-19 mitigation behaviors, and whether mitigation behaviors mediate the relationship between dementia and COVID-19 risk. The results showed that dementia significantly increased the odds of COVID-19 and decreased the odds of handwashing among older adults. The relationship between dementia and COVID-19 risk was primarily mediated by functional impairment, income, and residential setting.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Neurosciences
Seok Jong Chung et al.
Summary: This study retrospectively analyzed the data of COVID-19 patients in South Korea and observed the performance of Alzheimer's disease (AD) patients in terms of susceptibility to COVID-19 infection and severe complications. The study found that AD patients did not have an increased risk of COVID-19 infection but were at higher risk of severe complications and mortality.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Medicine, Research & Experimental
Fatemeh Rajati et al.
Summary: This systematic review and meta-analysis standardized the global prevalence of oropharyngeal dysphagia (OD) in different populations. The results showed that OD is highly prevalent in different populations and its prevalence has been increasing in recent years. Appropriate strategies should be implemented to reduce the prevalence of OD by identifying its causes, monitoring at all levels, and providing feedback to hospitals.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
M. Fathi et al.
Summary: The study compared the prognosis of inpatients with a known diagnosis of Alzheimer's or Parkinson's disease who have COVID-19 infection with other hospitalized patients with COVID-19. The findings showed that patients with Alzheimer's disease had a higher risk of mortality from COVID-19, while Parkinson's disease did not significantly predict higher mortality of COVID-19.
REVUE NEUROLOGIQUE
(2022)
Article
Multidisciplinary Sciences
Sevda Molani et al.
Summary: Risk stratification is crucial for decision-making and resource allocation in hospitalized COVID-19 patients. This study developed risk models to predict mechanical ventilation illness or death during hospitalization and found differences in the predictive value of age, BMI, vital signs, and laboratory results among different age groups.
SCIENTIFIC REPORTS
(2022)
Review
Geriatrics & Gerontology
Le-Tian Huang et al.
Summary: Inflammation and immune dysfunction play significant roles in the pathogenesis of Alzheimer's disease (AD)-related dementia. Changes in peripheral blood cell profiles, particularly involving leukocyte, lymphocyte, neutrophil, and CD8(+) T cell counts, as well as the neutrophil-lymphocyte ratio (NLR) and the CD4/CD8 ratio, are closely associated with AD. The diagnostic relevance of these profiles should be investigated in future.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Hamidreza Hatamabadi et al.
Summary: This study provides insights into the demographics and clinical characteristics of COVID-19 cases in Iran, and identifies factors associated with death and case fatality rate. The findings suggest that various factors, such as comorbidities and clinical profiles, contribute to an increased risk of death related to COVID-19. It also highlights the increasing trend of the case fatality rate during the observation period.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Immunology
Yauhen Statsenko et al.
Summary: This study found that age and sex are important factors influencing the severity of COVID-19. Older age and male sex were associated with a higher risk of severe disease. Lung involvement was more extensive in young males, but there was no significant difference in middle-aged and older adults. Middle-aged and older adults were more likely to have moderate or severe disease compared to young adults. The impact of sex on disease severity was more evident than that of age in this study.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Fernando Bartolome et al.
Summary: COVID-19 poses a greater risk to older adults and those with dementia. Lactoferrin may have antiviral and anti-inflammatory properties against SARS-CoV-2, improving immune system responses and potentially serving as a treatment for COVID-19. Reduced levels of lactoferrin in saliva may increase the susceptibility of Alzheimer's disease patients to COVID-19. Bovine lactoferrin may be a promising preventive therapeutic tool to minimize COVID-19 risk in dementia or Alzheimer's disease patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Uan- Chen et al.
Summary: This study examines the factors associated with COVID-19-related deaths using a large dataset. The findings indicate that age, sex, obesity, race, region, and various chronic diseases are associated with COVID-19-related deaths.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Clinical Neurology
Corrado Zenesini et al.
Summary: The study found that people with Parkinson's disease and parkinsonism had a higher risk of SARS-CoV-2 infection throughout the pandemic, while the risk of hospitalization for COVID-19 was increased only in patients with parkinsonism during the first wave.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Magda Bucholc et al.
Summary: This study investigated the association between various comorbidities and COVID-19 in-hospital mortality. The results showed that comorbidities such as lymphoma, metastatic cancer, liver disease, congestive heart failure, chronic obstructive pulmonary disease, obesity, renal disease, and dementia increased the risk of COVID-19 mortality, while asthma was associated with a lower risk of death. The study also found that the more comorbidities a patient had, the higher the risk of death.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Johannes A. Booij et al.
Summary: This study investigates the short- and long-term mortality and risk factors in nursing home patients with COVID-19 infection. The results show that COVID-19 infection increases the risk of death in the short and long term among nursing home patients. However, surviving COVID-19 infection does not lead to increased mortality in the long term within this population.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Medicine, General & Internal
Pratikkumar H. Vekaria et al.
Summary: Based on a retrospective cohort study, it was found that COVID-19 patients with dementia did not have significantly worse health outcomes compared to patients without dementia, and in fact, showed better outcomes in certain metrics.
FRONTIERS IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Jiyong Kim et al.
Summary: This study used real-world data from COVID-19 patients in South Korea to investigate the impact of patient demographics and comorbidities on the infection rate and severity of COVID-19. The results showed that patients with certain diseases such as pulmonary disease, diabetes, and cardiovascular disease had a higher infection rate, while patients with hyperlipidemia, autoimmune disease, and cancer had a lower infection rate. Additionally, kidney disease, hypertension, and dementia were associated with the severity of COVID-19.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Primary Health Care
Idoia Beobide Telleria et al.
Summary: This retrospective case-control study aimed to analyze the association between demographic, clinical, and pharmacological risk factors and SARS-COV-2 virus infection and identify variables related to mortality from COVID-19 in nursing home residents. The results showed that individuals with advanced dementia had a lower risk of SARS-CoV-2 infection but a higher risk of COVID-19 mortality. COPD diagnosis and chronic use of antipsychotics were also associated with mortality. These findings highlight the importance of determining the stage of diseases such as dementia and exercising caution in the use of certain drugs like antipsychotics.
Article
Medicine, General & Internal
Marko Lucijanic et al.
Summary: The study aimed to assess the long-term survival of COVID-19 patients after hospital discharge. The results showed that a substantial risk of death persisted after discharge, and factors such as age, functional impairment, treatment during hospitalization, inflammation markers, renal function, and specific comorbidities were independently associated with mortality.
CROATIAN MEDICAL JOURNAL
(2022)
Article
Psychiatry
Alexandre Descamps et al.
Summary: Pre-existing mental disorders are associated with increased in-hospital mortality and decreased ICU admission rates among adults hospitalized for COVID-19.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Alejandro Cisterna-Garcia et al.
Summary: This study develops a machine learning model using electronic medical records to predict mortality and hospitalization risk of COVID-19 patients. The model achieves high accuracy in predicting patient's final status and moderate accuracy in predicting hospitalization risk.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Chris Emmerson et al.
Summary: Dementia may increase the risk of COVID-19 among care home residents, particularly in homes with a high proportion of residents with dementia. Individual frailty is also associated with infection risk and all-cause mortality.
Review
Public, Environmental & Occupational Health
Omid Dadras et al.
Summary: Older people with COVID-19 have higher mortality rates. Age, BMI, male gender, dementia, impairment in daily activities, consolidations on chest X-ray, hypoxemic respiratory failure, and lower oxygen saturation at admission were risk factors for death. High d-dimer levels, vitamin D deficiencies, high C-reactive protein levels plus other abnormalities, higher blood urea nitrogen or lactate dehydrogenase, and higher platelet count were predictors of poor prognosis and mortality in the elderly.
HEALTH SCIENCE REPORTS
(2022)
Article
Geriatrics & Gerontology
A. de Malherbe et al.
Summary: This study aimed to determine the prevalence and serological evolution of COVID-19 in nursing homes and geriatric healthcare institutions, as well as the risk factors and clinical presentations among caregivers and residents. The results showed that the prevalence of COVID-19 was underestimated when using only one diagnostic method. Risk factors among residents included living in an Alzheimer unit and being a contact case, while the risk factor among caregivers was being a contact case and related to their profession. Both caregivers and residents showed persistent immunity during the 3-month follow-up. These findings support the French vaccination policy and suggest further research on the persistence of immunity and the potential mutations of COVID-19.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Clinical Neurology
Joseph Gaugler et al.
Summary: This article discusses the impact of Alzheimer's disease on public health, including its incidence, prevalence, mortality and morbidity rates, healthcare costs and caregivers' burden. It also addresses the perspectives of consumers and primary care physicians on mild cognitive impairment (MCI) and the need for improved awareness, diagnosis, and treatment. The article emphasizes the increasing number of individuals living with Alzheimer's and the challenges faced by caregivers and healthcare providers, particularly during the COVID-19 pandemic.
ALZHEIMERS & DEMENTIA
(2022)
Review
Clinical Neurology
Angelo Bianchetti et al.
Summary: This review discusses the complex relationship between COVID-19 and dementia, and how the pandemic has affected the management of dementia patients. Patients with dementia have a higher risk of contracting COVID-19 compared to those without dementia, and a diagnosis of dementia is an independent risk factor for hospitalization in COVID-19 patients. COVID-19 exacerbates the vulnerability of dementia patients and their caregivers, due to the higher morbidity and mortality rates, indirect effects on social support, and impacts on the healthcare system.
CURRENT TREATMENT OPTIONS IN NEUROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Man-Huei Chang et al.
Summary: The study examined the relationship between COVID-19 hospitalizations and chronic conditions among Medicare beneficiaries. Findings show that certain chronic conditions increased the risk of hospitalization, with disparities observed among different racial/ethnic groups, highlighting the need for targeted interventions in populations at higher risk.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2022)
Article
Clinical Neurology
Alberto Romagnolo et al.
Summary: This study evaluated the prevalence of neurological comorbidities in COVID-19 patients and found that neurological comorbidity is associated with COVID-19 severity. Patients with cerebrovascular diseases and cognitive impairment are particularly at higher risk for severe COVID-19.
JOURNAL OF NEUROLOGY
(2021)
Article
Immunology
Jingqi Zhou et al.
Summary: Our study found that patients with pre-existing Alzheimer's disease and dementia are at higher risk of hospital admission due to COVID-19, emphasizing the importance of providing special protective care for these individuals during the pandemic. Additionally, evidence suggests a direct association of genetic variants with COVID-19.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Daniel Munblit et al.
Summary: This study analyzed data of adult patients consecutively admitted for suspected COVID-19 infection in Moscow, revealing that age, male sex, and chronic comorbidities were risk factors for in-hospital mortality. Clinical features were sufficient for diagnosing COVID-19 infection, indicating that laboratory testing is not critical in real-life clinical practice.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Kyoung Ae Kong et al.
Summary: This study demonstrates that cardiovascular risk factors are significant risk factors for severe COVID-19. Patients with multiple cardiovascular risk factors are more likely to progress to severe COVID-19, highlighting the importance of early and appropriate treatment for these individuals.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Geriatrics & Gerontology
Mert Esme et al.
Summary: This study in Turkey focused on older adults hospitalized with COVID-19, finding significant associations between mortality and factors such as male gender, diabetes, heart failure, and dementia. Additionally, comorbidities like hypertension, chronic kidney disease, cancer, and malnutrition were identified as increasing the risk of mortality in certain age groups. The results confirmed the age-related relationship between specific comorbidities and COVID-19-related mortality.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Clinical Neurology
Katherine Holder et al.
Summary: COVID-19 is a pandemic disease caused by SARS-CoV-2, with elderly patients and those with age-related diseases like cardiovascular diseases, diabetes, and obesity being more susceptible to severe respiratory illnesses.
Article
Geriatrics & Gerontology
Victor Manuel Becerra-Munoz et al.
Summary: In elderly COVID-19 patients, those aged 75 and older are more prone to in-hospital complications and mortality, but have fewer ICU admissions. Age, chronic kidney disease, dementia, peripheral oxygen saturation, severe lymphopenia, and qSOFA score are independent predictors of mortality.
Article
Geriatrics & Gerontology
Yizhou Yu et al.
Summary: In December 2019, the COVID-19 pandemic began, resulting in over 45,000 deaths in the UK. Research indicates that elderly individuals with Alzheimer's disease face the highest risk of COVID-19 and mortality, while Parkinson's disease patients have a higher risk of SARS-CoV-2 infection.
Article
Geriatrics & Gerontology
Teodoro del Ser et al.
Summary: This study investigated the impact factors and clinical features of COVID-19 symptoms in a group of elderly volunteers aged 75-90. The study found that factors such as older age, male gender, genetic factors, and lifestyle habits may be associated with the incidence, severity, and mortality rates of COVID-19.
Article
Medicine, General & Internal
Pedro Pablo Espana et al.
Summary: Factors associated with risk of death from COVID-19 were investigated in a retrospective cohort study. Male gender, older age, hospitalization for COVID-19, and comorbidities such as cardiovascular disease, kidney disease, or dementia were found to increase mortality risk, while taking anticoagulants or lipid-lowering drugs at baseline was protective. Risk scores based on these factors could help identify high-risk individuals for targeted preventive measures and follow-up.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Immunology
Hector S. Izurieta et al.
Summary: This study found that frailty, comorbid conditions, and race/ethnicity are significant risk factors for COVID-19 hospitalization and death among elderly individuals in the United States.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Neurosciences
Mehran Ghaffari et al.
Summary: Neurological symptoms are common in patients with COVID-19, including headaches and loss of smell. Dementia may increase the risk of severe COVID-19. Patients with neurological complications have a higher mortality rate and require more intensive care.
JOURNAL OF NEUROVIROLOGY
(2021)
Article
Geriatrics & Gerontology
Paola Rebora et al.
Summary: In this study, the prevalence of delirium on admission in patients with SARS-CoV-2 infection was reported to be 14.1%, with factors such as dementia, number of chronic diseases, and chest X-ray or CT opacity being significantly associated with delirium. Patients with delirium on admission had a higher in-hospital mortality rate compared to those without delirium.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Review
Geriatrics & Gerontology
Rafael Bielza et al.
Summary: Around 45% of residents living in nursing homes with COVID-19 died within 30 days of first attention, with more than three-quarters experiencing a severe form of the disease. Atypical symptoms such as altered level of consciousness should be considered in this population.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Clinical Neurology
Luca Vignatelli et al.
Summary: The study found that Parkinson's disease per se is probably not a risk factor for COVID-19 hospitalization, while parkinsonism may be an independent risk factor. Parkinsonism patients may have a higher risk of infection due to their more severe health status, higher care dependence, and placement in high-infection-risk accommodations.
MOVEMENT DISORDERS
(2021)
Editorial Material
Clinical Neurology
Katya Numbers et al.
Summary: People with dementia are at high risk of SARS-CoV-2 infection due to cognitive symptoms and living arrangements in care homes. Once infected, they are more likely to experience severe outcomes and death. Certain genotype may increase the risk of COVID-19 hospitalization, and dementia in older adults, especially those in care homes, can lead to worsening psychiatric symptoms and severe behavioral disturbances during the pandemic.
NATURE REVIEWS NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Valentina Orlando et al.
Summary: This study identified conditions and diseases that make people more vulnerable to SARS-CoV-2 infection, supporting decision-makers in identifying high-risk individuals and adopting preventive measures to minimize the spread of further epidemic waves.
Article
Neurosciences
Qiang Zhang et al.
Summary: This study found that Alzheimer's disease is an independent risk factor for COVID-19 case fatality rate, while patients with vascular dementia did not show a similar increased risk. These findings are relevant to the evolving COVID-19 pandemic.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Orestis A. Panagiotou et al.
Summary: In this cohort study of 5256 US nursing home residents with COVID-19, older age, male gender, and impaired cognitive and physical function were independently associated with increased mortality risk. Identifying these risk factors can help in developing clinical prediction models for mortality in this population.
JAMA INTERNAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Mustafa Alsahab et al.
Summary: Age and frailty are independently associated with adverse outcomes in COVID-19. The risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age.
Article
Clinical Neurology
QuanQiu Wang et al.
Summary: Patients with dementia are at increased risk for COVID-19 compared to those without dementia, with vascular dementia carrying the highest risk. Black patients with dementia have a higher risk of COVID-19 compared to White patients.
ALZHEIMERS & DEMENTIA
(2021)
Article
Multidisciplinary Sciences
Erjia Ge et al.
Summary: The study revealed that comorbidities play a significant role in the mortality and severity of COVID-19 patients, with a higher number of comorbidities associated with increased risks. Specifically, comorbidities were found to have a greater impact on younger individuals, emphasizing the importance of prioritizing vaccination for younger populations with multiple comorbidities.
Article
Multidisciplinary Sciences
Siranush Karapetyan et al.
Summary: This study investigated predefined risk factors associated with testing positive for SARS-CoV-2 infection and cardiovascular or pulmonary complications in outpatient settings. Common risk factors for a positive PCR test result included dementia, type 2 diabetes, and obesity, while significant risk factors for cardiovascular or pulmonary complications were coronary heart disease, hypertension, tobacco consumption, chronic obstructive pulmonary disease (COPD), previous pneumonia, chronic kidney disease (CKD), and type 2 diabetes. Simple decision rules based on age, hypertension, CKD, COPD, and CHD were effective in identifying high-risk patients with a good level of sensitivity and specificity, which could help improve care for patients at risk.
Article
Medicine, General & Internal
H. Raheja et al.
Summary: The study found that age and dementia are associated with increased odds for mortality in COVID-19 patients aged >= 75 years, while presenting with diarrhea symptom was associated with lower odds for mortality. Those who were classified as having severe/very severe or critical disease also had increased odds for mortality.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Chansik An et al.
Summary: A tool was developed to predict prognosis and guide early triage of COVID-19 patients using a Korean national cohort and validated with an external cohort. Predictors included age, sex, symptoms, and underlying diseases. The tool performed well in external validation and outperformed current protocols recommended in Korea.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
C. Khatri et al.
Summary: This study included 1063 patients from 174 hospitals in 19 countries and found that patients undergoing surgery for proximal femoral fractures with perioperative SARS-CoV-2 infection have a high 30-day mortality rate of 29.4%. Factors associated with mortality included male gender, age over 80, preoperative diagnosis of dementia, kidney disease, and congestive heart failure.
Article
Environmental Sciences
Michal Chojnicki et al.
Summary: The study identified male sex, severe cognitive impairment, underlying heart disease, anemia, and elevated plasma levels of IL-6 as independent factors associated with greater mortality in older adults with COVID-19. Functional impairment was the key determinant of increased mortality during the overall 180-day observation period.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Ana C. Tahira et al.
Summary: Dementia and Alzheimer's disease are independent risk factors for disease severity and death in COVID-19.
ALZHEIMERS & DEMENTIA
(2021)
Article
Infectious Diseases
Lisa Cummins et al.
Summary: The study identified age, sex, ethnicity, obesity, CKD, and diabetes as important determinants of risk of COVID-19 hospitalisation or death, while also highlighting the need to protect individuals with learning disabilities and multi-morbidities during COVID-19 waves.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2021)
Article
Medicine, General & Internal
Sergio Venturini et al.
Summary: Using machine learning models, this study analyzed non-critically ill COVID-19 patients in a general medicine ward to identify predictors for clinical outcomes. The results found that factors such as glomerular filtration rate, creatinine, and serum sodium were promising predictors for the clinical outcome.
INTERNAL MEDICINE JOURNAL
(2021)
Article
Health Care Sciences & Services
Alexandre Worcel et al.
Summary: The COVID-19 prevention and treatment protocol implemented at a nursing facility in France resulted in lower incidence and mortality rates compared to other similar facilities, demonstrating significant effectiveness in combating the virus.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Clinical Neurology
Raphael Scherbaum et al.
Summary: The study found that hospitalizations for PD transiently decreased in 2020 compared to 2019, and the frequency of COVID-19 was significantly higher in PD patients, especially in older age groups. COVID-19(+) inpatients with PD showed higher incidences of established risk comorbidities than non-PD COVID-19(+) subjects, particularly hypertension and chronic kidney disease.
MOVEMENT DISORDERS
(2021)
Review
Clinical Neurology
Cynthia Putri et al.
Summary: The meta-analysis revealed a significant association between Parkinson's Disease and in-hospital outcomes of COVID-19, with PD patients at higher risk of severe illness and mortality. Age was identified as a factor influencing this association. Careful monitoring and preventive measures are recommended for PD patients to minimize the risks of infections.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Multidisciplinary Sciences
Avishek Chatterjee et al.
Summary: The study found that age is an important predictor of mortality risk in COVID-19 patients. Comorbidities such as smoking, male gender, hypertension, diabetes, dementia, cancer, chronic obstructive pulmonary disease, chronic cardiac disease, chronic neurological disease, and chronic kidney disease are associated with an increased risk of death. In the external validation set, the age-only model outperformed all other modeling attempts.
Article
Multidisciplinary Sciences
Ali Zakaria et al.
Summary: The study found that gender significantly modified the association between race and COVID-19 mortality, with African American females having the lowest all-cause in-hospital mortality risk compared to other gender-race groups.
Article
Immunology
Antonio Giampiero Russo et al.
Summary: Evidence from COVID-19 outbreak suggests that individuals with specific chronic diseases are at higher risk of severe prognosis, prompting public health authorities to prioritize vaccination programmes targeting the frailest subjects to minimize deaths and preserve health service resilience. Analysis of data from 146,087 COVID-19 cases in Milan identified high-risk categories for mortality, allowing for prioritization in vaccination strategies. Results showed that older age categories shared common risk factors, while younger age categories had different predictors.
Article
Environmental Sciences
Rosa Magallon-Botaya et al.
Summary: The study found that women have better prognosis in COVID-19, with most comorbidities associated with poorer prognosis. Suburban areas are linked to higher mortality and less hospital or ICU admissions. Proximity to hospitals also affects patient hospitalization.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Respiratory System
Eric Ouattara et al.
Summary: This retrospective cohort analysis of 98,366 COVID-19 patients hospitalized in France during the first half of 2020 revealed that age was the main risk factor for death in both CCU and HCU patients. Most underlying chronic conditions were also associated with mortality.
BMJ OPEN RESPIRATORY RESEARCH
(2021)
Article
Critical Care Medicine
Ashish Bhargava et al.
Summary: This study conducted a retrospective study on patients with COVID-19 infection at a tertiary care center in Detroit, Michigan, identifying age, comorbidities, and laboratory data as risk factors for in-hospital mortality.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Review
Cell Biology
Kai-Min Wu et al.
Summary: Alzheimer's disease is characterized by the accumulation of amyloid plaques and tau tangles, with increasing evidence suggesting that the immune system plays a vital role in AD etiology and pathogenesis. The recognition of misfolded proteins by immune cells can lead to neuroinflammation and neurodegeneration, while genetic susceptibility and other immune-related factors also contribute to AD development. Further research on immune cell alterations, gene susceptibility, and immune-related mechanisms may provide new insights for potential immunotherapies and biomarkers for AD.
AGEING RESEARCH REVIEWS
(2021)
Review
Cell Biology
Albin John et al.
Summary: The COVID-19 pandemic has severely strained the medical system, with elderly individuals and those with comorbidities facing higher risks. Studying the impact of COVID-19 on AD patients provides insights into how the virus affects vulnerable populations through aging.
AGEING RESEARCH REVIEWS
(2021)
Article
Emergency Medicine
Vincenzo G. Menditto et al.
Summary: This study investigated the readmission rate within 14 days of patients with COVID-19 discharged from emergency departments. It found that 22.9% of patients had a return ED visit within 14 days, with 11% of them requiring hospitalization. Age, pro-calcitonin, and D-dimer levels were identified as major predictors for return hospital admission.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Geriatrics & Gerontology
Marcello Covino et al.
Summary: Among hospitalized COVID-19 patients over 80 years old, factors such as consolidations at chest x-ray and hypoxemic respiratory failure were significant predictors of poor prognosis. Additionally, advancing age, dependency in activities of daily living, and dementia were identified as strong risk factors for in-hospital death, independent of disease severity. Various scoring systems showed good predictive value in identifying patients at risk of worse outcomes.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Review
Medicine, General & Internal
Marina Treskova-Schwarzbach et al.
Summary: This study used an umbrella review approach to summarize global evidence on the risk of severe COVID-19 outcomes in patients with pre-existing health conditions. The risk of adverse COVID-19 health outcomes is consistently increased in certain patient subgroups across geographical regions, showing high variability in others. The results can help inform COVID-19 vaccine prioritization or other intervention strategies.
Article
Psychiatry
Tim M. Gale et al.
Summary: The study presented data on outcomes associated with COVID-19 among patients receiving treatment from a mental health and learning disabilities service provider within secondary care services. A small percentage of patients died after contracting COVID-19, with males, older individuals, and those with dementia being more at risk. Higher HoNOS scores were associated with worse outcomes, but the importance of dementia diagnosis was highlighted. The study suggests the need for further research on inequalities in healthcare for individuals with severe mental health problems.
COMPREHENSIVE PSYCHIATRY
(2021)
Article
Neurosciences
Jeanine J. S. Rutten et al.
Summary: Male gender, dementia, and Parkinson's disease were significant risk factors for mortality in Dutch nursing home residents with COVID-19, while being male was also associated with higher mortality in the control group. Dementia and Parkinson's disease were unique risk factors for mortality in COVID-19 patients, indicating the importance of considering frailty in care planning for these patients.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Marcello Covino et al.
Summary: In a cohort of adults aged >80 years, factors such as clinical severity, comorbidities, cognitive impairment, and frailty overlap to stratify the in-hospital death risk of COVID-19 older patients. Comprehensive evaluation based on these factors is essential for effective prediction of outcomes in older COVID-19 patients.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Carlo Fumagalli et al.
Summary: The study found that pre-morbid functional status and frailty in COVID-19 patients aged >= 75 years were associated with mortality. Combining Barthel Index (BI), modified Frailty Index (mFI), and COVID-19 Mortality Risk Score (COVID-19 MRS) improved the accuracy of mortality prediction. This suggests that incorporating functional status and frailty assessment may be helpful in guiding clinical management of older individuals with COVID-19.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Clinical Neurology
Alberto Romagnolo et al.
Summary: This study found that patients with pre-existing neurological diseases, especially neurodegenerative diseases, had a significantly increased case fatality rate after contracting COVID-19, highlighting the importance of viral screening, access to care facilities, and vaccination for these populations.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Brad Tyson et al.
Summary: Our study found that patients with dementia and altered mental status are more likely to die in older adults hospitalized with COVID-19, highlighting the importance of early recognition and mental status assessment in the medical evaluation of COVID-19.
NEUROLOGICAL SCIENCES
(2021)
Letter
Clinical Neurology
Mehri Salari et al.
Summary: PD patients have a higher Covid-19 mortality rate compared to other hospitalized patients. Factors such as PD pathophysiology, advanced age, underlying conditions, and health systems' efficacy may contribute to this outcome.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Multidisciplinary Sciences
Yong Jun Choi et al.
Summary: This study found that patients with COVID-19 who have underlying chronic diseases have a poorer prognosis. Specific underlying diseases significantly increase treatment costs or prolong hospital stays, and even increase the risk of death.
Article
Multidisciplinary Sciences
In Sook Kang et al.
Summary: The study revealed a non-linear (U-shaped) relationship between BMI and fatal illness. Patients with a BMI of <18.5 kg/m(2) and those with a BMI >=25 kg/m(2) were at a higher risk of fatal illness. Maintaining a healthy weight is crucial for not only preventing chronic cardiometabolic diseases but also improving outcomes of COVID-19.
Article
Multidisciplinary Sciences
Uxio Meis-Pinheiro et al.
Summary: This study investigated the natural history of COVID-19 in older adults and found that some comorbidities and symptoms have a strong predictive value for mortality. The infection rate was 28%, with 71% of residents showing symptoms, including fever and dyspnea. The study provides insights into the disease progression and mortality predictors in long-term nursing homes during the early months of the pandemic.
Article
Psychiatry
Sheng-Min Wang et al.
Summary: Our study found that patients with dementia had a higher mortality rate and were more likely to require invasive ventilatory support after COVID-19 compared to those without dementia. Multivariable analysis showed that the dementia group had a significantly higher risk of mortality compared to the no dementia group.
PSYCHIATRY INVESTIGATION
(2021)
Review
Neurosciences
Jenny Lutshumba et al.
Summary: Neuroinflammation involves interactions between microglia, systemic immune cells, and cytokines, with changes orchestrated by immune cells in both the brain and peripheral system. Both innate and adaptive immune cells, such as T cells and B cells, contribute to chronic neuroinflammation and dementia. Neurodegenerative pathology, infection, or injury can combine to trigger persistent microglial and brain inflammation, with lymphocytes playing a key role in inflammation and potential dementia progression.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Julia Hippisley-Cox et al.
Summary: This study derived and validated risk prediction algorithms to estimate the risk of covid-19 related mortality and hospital admission in UK adults after one or two doses of covid-19 vaccination. The study found that the risk of covid-19 mortality and hospital admission was associated with age, sex, ethnic origin, deprivation, body mass index, a range of comorbidities, and SARS-CoV-2 infection rate. Various conditions, such as Down's syndrome, kidney transplantation, sickle cell disease, and certain other diseases, were identified as having higher risk of covid-19 mortality.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Review
Geriatrics & Gerontology
Mingchao Shi et al.
Summary: Alzheimer's disease is a global public health priority affecting over 40 million people worldwide. The role of infections in the pathogenesis of Alzheimer's disease is still unclear, but recent studies suggest that infection and chronic inflammation may be crucial risk factors. While the causal relationship between infection and Alzheimer's disease is difficult to determine, infections may act as accelerators in the progression of the disease. Conducting longitudinal studies and randomized controlled trials in humans to explore the links between infection and Alzheimer's disease could lead to more promising clinical therapeutic strategies.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Mariantonietta Pisaturo et al.
Summary: This study found that patients with dementia are more likely to develop severe illness and die when infected with COVID-19, and are more likely to experience delirium symptoms during the disease.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Environmental Sciences
Vicente Paulo Alves et al.
Summary: This meta-analysis evaluated the factors associated with mortality of elderly Italians diagnosed with COVID-19, with dementia, diabetes, chronic kidney disease, and hypertension being the main morbidities identified.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Alan P. Pan et al.
Summary: Cognitive impairment may increase susceptibility to SARS-CoV-2 infection, but does not necessarily confer a higher risk of mortality from COVID-19. Targeted prevention strategies are needed for this vulnerable sub-population.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Kristina S. Boye et al.
Summary: This study found diabetes to be an independent risk factor for COVID-19 complications, with factors such as age, gender, dementia, metastatic tumors, congestive heart failure, paraplegia, and metabolic diseases also affecting hospitalization risk. Notably, metformin was associated with lower odds of hospitalization, while sulfonylureas and insulins were associated with higher odds in T2D patients.
Article
Medicine, General & Internal
Jesus Castilla et al.
Summary: This prospective study in Spain found that certain demographic factors and chronic conditions were associated with higher risks of SARS-CoV-2 infection, hospitalization, and death. It identified groups such as the older population, nursing home residents, and individuals with specific health conditions as priorities for COVID-19 prevention and vaccination. The study also highlighted the need for additional support for immigrants in terms of preventive measures.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Mona Mahmoud et al.
Summary: The study found that older COVID-19 patients with a higher risk of in-hospital mortality were males, older patients, and patients with dementia or cerebrovascular diseases. Through clustering analysis, it was discovered that the Neurocognitive and Metabolic-renal-cancer clusters had a higher mortality rate compared to the Unspecified cluster.
FRONTIERS IN MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Yongjun Wang et al.
Summary: The study found that individuals with mental disorders have a significantly higher risk of developing COVID-19 and facing higher mortality rates, particularly in dementia patients. Late-life anxiety only increases the risk of infection, while late-life depression is associated with both higher infection risk and worse outcomes.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Tellen D. Bennett et al.
Summary: The study evaluated COVID-19 severity and risk factors in over 1.9 million US adults, finding that machine learning models can accurately predict clinical severity. It also observed a decrease in COVID-19 mortality over time in 2020 and identified associations between patient demographic characteristics and comorbidities with higher clinical severity.
Article
Public, Environmental & Occupational Health
Sarah M. Baker et al.
Summary: Dementia, old age, and residing in congregate living facilities are risk factors associated with mortality in COVID-19 patients. Implementing an operational palliative care consult service can facilitate early identification of high-risk patients and provide goal-concordant care during a pandemic.
HEALTH SCIENCE REPORTS
(2021)
Article
Psychiatry
Jeon-Yeon Seon et al.
Summary: Patients with mental illness are at higher risk for SARS-CoV-2 infection and COVID-19-related death, especially those with severe mental illness, dementia, and substance use disorder. Behavioral changes associated with cognitive deterioration and delayed treatment increase the vulnerability of these patients to the virus.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2021)
Article
Medicine, General & Internal
Hui Jeong Moon et al.
Summary: This study investigated the factors associated with mortality in COVID-19 patients and developed a nomogram for predicting mortality accurately. Differences in age, gender, underlying diseases, and symptoms were found to be closely related to survival and mortality rates in COVID-19 patients.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Critical Care Medicine
Mohammad M. Banoei et al.
Summary: The study utilized a SIMPLS-based model to analyze clinical features and comorbidities of COVID-19 patients, identifying important predictors for predicting hospital mortality, such as coronary artery disease and diabetes. By using machine learning methods, clustering analysis was performed to classify high- and low-risk patients among COVID-19 survivors.
Article
Infectious Diseases
M. Martinot et al.
Summary: This study examined 600 patients diagnosed with COVID-19 in Colmar Hospital, Northeastern France, and found that baseline independent factors associated with death included older age, male sex, oxygen supply, and other comorbidities. Factors associated with ICU hospitalization were younger age, oxygen supply, and specific comorbidities. The study also revealed a high frequency of extrapulmonary complications, especially in ICU patients.
INFECTIOUS DISEASES NOW
(2021)
Article
Medicine, General & Internal
Sohyun Bae et al.
Summary: A new mortality scoring system for inpatients with COVID-19 was developed based on simple demographic factors and laboratory findings, which was validated using data from 10 hospitals. Key predictors for the system included age, diabetes, chronic kidney disease, and others. The system showed high accuracy in predicting mortality risk, helping physicians tailor therapy and strategies for individual patients.
YONSEI MEDICAL JOURNAL
(2021)
Article
Orthopedics
B. Ajayi et al.
Summary: The study compared the impact of the first and second waves of the COVID-19 pandemic on major trauma and orthopaedic patients, showing an increase in infected patients in the second wave, doubling the number of operative cases, quadrupling the cases of ICU admissions, and a decrease in dementia and cardiovascular disease among younger patients with lower mortality rates.
Article
Geriatrics & Gerontology
Isabel Lozano-Montoya et al.
Summary: This study aimed to describe the baseline characteristics of oldest-old patients admitted with COVID-19 and determine factors associated with in-hospital mortality. Findings revealed dementia, incident delirium, and a CURB-65 score >= 3 as independent mortality risk factors, with concurrent use of angiotensin-converting enzyme inhibitors as a protective factor. Recognition of geriatric syndromes may help establish prognosis of oldest-old patients with COVID-19.
EUROPEAN GERIATRIC MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Eun Kyong Shin et al.
Summary: This study found that chronic kidney disease, chronic obstructive pulmonary disease, heart failure, malignancy, dementia, and diabetes mellitus were associated with an increased risk of death in COVID-19 patients. Asthma and hypertension did not show statistically significant associations with an increased risk of death.
EPIDEMIOLOGY AND HEALTH
(2021)
Article
Geriatrics & Gerontology
Pamela Carrillo-Garcia et al.
Summary: This study examined factors associated with mortality at 3 months and readmissions, as well as functional and cognitive decline, anorexia, and mood disorders in patients over 70 years old after hospital admission for SARS-CoV-2. Results showed that severe dependence at discharge was linked to higher risks of mortality and readmissions at 3 months. Functional deterioration post-hospitalization was associated with continued decline at 3 months, along with cognitive and affective deterioration.
EUROPEAN GERIATRIC MEDICINE
(2021)
Article
Medicine, General & Internal
Mehdi Hasani Azad et al.
Summary: This study aimed to review and evaluate evidence reporting injection site adverse effects with LAI antipsychotics, and found a low incidence of these adverse effects. Some studies compared injection site reactions between different LAI antipsychotics.
ARCHIVES OF IRANIAN MEDICINE
(2021)
Article
Health Care Sciences & Services
Jiandong Zhou et al.
Summary: This study developed a simple risk score based on clinical and laboratory variables for predicting the severity of COVID-19 disease. The risk score demonstrated excellent predictive value based on test results taken on the day of admission, even without including symptoms, blood pressure or oxygen status. External validation results also confirmed the accuracy of this scoring system.
NPJ DIGITAL MEDICINE
(2021)
Article
Health Policy & Services
Shenae Samuels et al.
Summary: This study examined characteristics, epidemiology, and predictors of outcomes among confirmed COVID-19 cases in a large community healthcare system in Florida. Results indicated that factors such as age, temperature, comorbidity, oxygen saturation, and specific diseases were associated with increased risks of hospitalization, ICU admission, readmission, and death. Demographics and vital signs at triage were found to play a significant role in determining patient outcomes.
JOURNAL OF COMMUNITY HEALTH
(2021)
Article
Medicine, General & Internal
Shin-Woo Kim et al.
Summary: The COVID-19 outbreak in Daegu, Korea was controlled by the end of March 2020. A retrospective, multicenter cohort study conducted on 7,057 laboratory-confirmed patients revealed that 77% were asymptomatic to mild. Key risk factors for 28-day mortality included age, need for O-2 supply, fever, and underlying health conditions like diabetes and cancer.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Mehmet Nuri Yakar et al.
Summary: This study found a high 28-day mortality rate in critically ill patients with COVID-19, with sepsis/septic shock, acute kidney injury, acute cardiac injury, and chest CT score higher than 15 being identified as independent risk factors for mortality. Early detection of these risk factors and the use of chest CT score may help improve outcomes in COVID-19 patients.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Editorial Material
Medicine, General & Internal
Thomas A. Bledsoe et al.
ANNALS OF INTERNAL MEDICINE
(2020)
Article
Medicine, General & Internal
Armand H. Matheny Antommaria et al.
ANNALS OF INTERNAL MEDICINE
(2020)
Review
Immunology
Michael J. Butler et al.
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Geriatrics & Gerontology
A. Bianchetti et al.
JOURNAL OF NUTRITION HEALTH & AGING
(2020)
Article
Medicine, General & Internal
Christopher M. Petrilli et al.
BMJ-BRITISH MEDICAL JOURNAL
(2020)
Article
Public, Environmental & Occupational Health
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2020)
Review
Geriatrics & Gerontology
Janko Nikolich-Zugich et al.
Article
Endocrinology & Metabolism
Luca Busetto et al.
Article
Cell Biology
Yan Wan et al.
Letter
Geriatrics & Gerontology
Satoshi Miyashita et al.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2020)
Article
Geriatrics & Gerontology
Marcello Covino et al.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2020)
Article
Medicine, General & Internal
Geehan Suleyman et al.
Article
Geriatrics & Gerontology
Robert De Smet et al.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2020)
Article
Geriatrics & Gerontology
Janice L. Atkins et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Clinical Neurology
Alfonso Fasano et al.
MOVEMENT DISORDERS
(2020)
Article
Clinical Neurology
Jong-moon Hwang et al.
NEUROLOGICAL SCIENCES
(2020)
Editorial Material
Geriatrics & Gerontology
Yat F. Shea et al.
Article
Geriatrics & Gerontology
Joy Antonelle de Marcaida et al.
Article
Geriatrics & Gerontology
Bastien Genet et al.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2020)
Review
Clinical Neurology
M. Reza Azarpazhooha et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2020)
Article
Medicine, Research & Experimental
Donogh Maguire et al.
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Medicine, General & Internal
Stephanie L. Harrison et al.
Review
Physiology
Meizi Wang et al.
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Neurosciences
Nanyang Liu et al.
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Multidisciplinary Sciences
Thomas D. Filardo et al.
Article
Medicine, General & Internal
Tayfun Caliskan et al.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2020)
Article
Respiratory System
Maria Gomez Antunez et al.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2020)
Article
Medicine, General & Internal
Gie Ken-Dror et al.
Article
Psychiatry
Gill Livingston et al.
Article
Multidisciplinary Sciences
Andrew Tsai et al.
SCIENTIFIC REPORTS
(2020)
Article
Orthopedics
B. Ajayi et al.
Review
Medicine, General & Internal
Cemal Bulut et al.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2020)
Review
Psychology, Clinical
Mike W. -L. Cheung
NEUROPSYCHOLOGY REVIEW
(2019)
Article
Health Care Sciences & Services
Paul T. von Hippel
BMC Medical Research Methodology
(2015)
Review
Medicine, General & Internal
Frances Bunn et al.
Article
Medicine, General & Internal
Robert L. Grant
BMJ-BRITISH MEDICAL JOURNAL
(2014)
Review
Respiratory System
Antoni Torres et al.
Article
Medicine, General & Internal
Susan L. Mitchell et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2009)
Review
Medicine, General & Internal
David Moher et al.
Article
Medicine, General & Internal
E von Elm et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2004)
Article
Medicine, General & Internal
DF Stroup et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2000)
