期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1111/bjh.18933
关键词
adoptive immunotherapy; antigen immunodominance; immune compromised patients; off-the-shelf; respiratory syncytial virus (RSV); virus-specific T cells
类别
RSV-associated viral infections are a significant public health concern for immunologically naive/compromised populations. This study investigates the cellular immune response to RSV and develops targeted T cell therapy for immunocompromised individuals. A clinical trial is currently ongoing to evaluate the safety and activity of these RSV-targeted T cells in haematopoietic stem cell transplant recipients as an off-the-shelf multi-respiratory virus-directed product (NCT04933968).
Respiratory syncytial virus (RSV)-associated viral infections are a major public health problem affecting the immunologically naive/compromised populations. Given the RSV-associated morbidity and the limited treatment options, we sought to characterize the cellular immune response to RSV to develop a targeted T cell therapy for off-the-shelf administration to immunocompromised individuals. Here we report on the immunological profiling, as well as manufacturing, characterization and antiviral properties of these RSV-targeted T cells. A randomized, phase 1/2 clinical trial evaluating their safety and activity in haematopoietic stem cell transplant recipients as an off-the-shelf multi-respiratory virus-directed product is currently underway (NCT04933968, ).
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