Production of functional plasmacytoid dendritic cells - targeted chimeric antigen receptor T cells from patients with immune-mediated inflammatory diseases

Our preliminary results demonstrate the feasibility of CAR123 production from the T cells of patients with autoimmune diseases and immune-mediated inflammatory diseases and their in vitro cytotoxicity towards circulating autologous plasmacytoid dendritic cells.

Automated summary

Our preliminary results indicate the potential for CAR123 production from patient T cells with autoimmune diseases and immune-mediated inflammatory diseases, and their ability to exhibit cytotoxicity towards autologous plasmacytoid dendritic cells in vitro.