Comorbidities in palmoplantar pustulosis: a Swedish population-based register study

This study investigated the comorbidity burden of Swedish patients with palmoplantar pustulosis (PPP) vs. the general population and patients with psoriasis vulgaris (PV). We found a significantly higher comorbidity burden in patients with PPP compared with the general population, represented by higher odds for disease across different categories (metabolic, cerebrovascular, cardiovascular, psychiatric). Although patients with PPP and PV showed similar comorbidity burdens overall, the comorbidity profiles differed significantly. Comorbidities such as type 2 diabetes and chronic obstructive pulmonary disorder, which showed both high prevalence (> 5%) in PPP and higher odds than PV, may be of particular importance for the specific comorbidity burden of PPP.

Automated summary

This study compared the comorbidity burden of Swedish patients with palmoplantar pustulosis (PPP) with the general population and patients with psoriasis vulgaris (PV). The results showed a significantly higher comorbidity burden in PPP patients compared to the general population, with increased odds for diseases in different categories (metabolic, cerebrovascular, cardiovascular, psychiatric). Although PPP and PV patients had similar overall comorbidity burdens, the comorbidity profiles differed significantly. Comorbidities such as type 2 diabetes and chronic obstructive pulmonary disorder, which had a high prevalence (> 5%) in PPP and higher odds than PV, may be of particular importance for the specific comorbidity burden of PPP.