4.5 Editorial Material

Medication adherence research comes of ageY

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Article Pharmacology & Pharmacy

Evaluation of adherence monitoring in buprenorphine treatment: A pilot study using timed drug assays to determine accuracy of testing

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Summary: This study aimed to identify factors associated with a negative urine drug screen for buprenorphine in opioid agonist treatment patients. The study found that 57% of tested samples yielded a negative result, but it cannot be assumed that these patients have poor adherence to treatment.

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Methodological considerations on estimating medication adherence from self-report, electronic monitoring and electronic healthcare databases using the TEOS framework

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Summary: Measuring medication adherence is complex due to various contexts. The TEOS framework offers a process to operationalize adherence. This study aims to develop recommendations for quantification of medication adherence using self-report, electronic monitoring, and electronic healthcare databases.

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Scalability of effective adherence interventions for patients using cardiovascular disease medication: A realist synthesis-inspired systematic review

Stijn Hogervorst et al.

Summary: This review study investigates the scalability of medication adherence interventions and identifies six domains that are relevant for scalability. However, there is limited reporting on scalability in effectiveness trials for cardiovascular disease medication adherence interventions.

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Major disparities in patient-reported adherence compared to objective assessment of adherence using mass spectrometry: A prospective study in a tertiary-referral hypertension clinic

James M. G. Curneen et al.

Summary: This study aimed to compare patient-reported adherence to antihypertensive medications with objective evidence. By using mass spectrometry spot urinalysis, the research found that combining spot urine mass spectrometry and self-reporting can identify higher rates of nonadherence in patients attending a tertiary hypertension clinic.

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Estimation of adherence to medication treatment in presence of censoring

Jerome Pasquier et al.

Summary: The study aims to provide a theoretical framework for the analysis of medication adherence based on longitudinal data and suggests methods for unbiased estimation of the effect of time and covariates on adherence.

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Examining nonadherence in the treatment of tuberculosis: The patterns that lead to failure

William S. Fox et al.

Summary: The pattern of medication adherence is important for treatment outcomes, and missing treatment days in clusters rather than randomly increases the risk of poor outcomes. Older patients and those who experience adverse events are associated with lower adherence.

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An allopurinol adherence tool using plasma oxypurinol concentrations

Natalia Smith-Diaz et al.

Summary: This study developed and evaluated an allopurinol adherence tool based on oxypurinol plasma concentrations, which can be used to identify gout patients who need additional support to maintain adherence. The tool showed good predictive performance and could be useful in adherence screening in clinical trials and some clinical practice settings.

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Optimizing adherence to allopurinol for gout: patients' perspectives

Jane C. J. Spragg et al.

Summary: This study aimed to explore the facilitators and barriers to allopurinol adherence among people with gout, as well as their perspectives on strategies to improve adherence, such as self-monitoring of urate concentration. The results showed that patient perceptions of the effectiveness and necessity of allopurinol influenced intentional adherence during medication initiation, implementation, and discontinuation. Providing accurate medical advice and informing patients of their urate control have the potential to improve adherence to allopurinol.

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TEOS: A framework for constructing operational definitions of medication adherence based on Timelines-Events-Objectives-Sources

Alexandra L. Dima et al.

Summary: Managing adherence to medications is a global health priority, but adherence research is limited by methodological constraints, particularly the heterogeneity and low accuracy of adherence measures. Recent guidelines suggest best practices, but operational definitions are rarely included in study reports. Therefore, to support researchers in adherence measurement decision-making, a structured approach has been developed.

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Practical Barriers to Medication Adherence: What Do Current Self- or Observer-Reported Instruments Assess?

Amy Hai Yand Chan et al.

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Improving medication adherence research reporting: ESPACOMP Medication Adherence Reporting Guideline (EMERGE)

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The myths of medication adherence

Walid F. Gellad et al.

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2017)