4.7 Review

Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pharmacology & Pharmacy

Recent advances in clinical trials targeting the kynurenine pathway

Ananda Staats Pires et al.

Summary: The kynurenine pathway (KP) is a crucial pathway for the metabolism of tryptophan, an essential amino acid. Activation of KP under inflammatory conditions produces various metabolites that have the potential to affect redox activity, immune response, and neurotoxicity. Dysregulation of this pathway has been implicated in a wide range of neurological diseases and psychiatric disorders.

PHARMACOLOGY & THERAPEUTICS (2022)

Review Oncology

The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated

Roumaissa Gouasmi et al.

Summary: The kynurenine pathway plays important roles in tumor development by protecting organs from immune reactions and providing essential metabolites to cells. Abnormal activation of this pathway promotes tumor growth, metastasis, and chemoresistance. The complex regulation of this pathway poses challenges for clinical interventions.

CANCERS (2022)

Review Oncology

Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy

Yu Fujiwara et al.

Summary: Strategies to overcome immunosuppression in the tumor microenvironment, such as IDO1 inhibition, have been explored to address resistance to immune checkpoint blockade. These strategies have shown promising results in preclinical studies and early-phase clinical trials. However, some clinical trials have yielded disappointing results, dampening enthusiasm for IDO inhibitors. Additional potential targets, such as the aryl hydrocarbon receptor and tryptophan 2,3-dioxygenase, have been proposed to enhance clinical effectiveness. The expression level of IDO1 varies among tumors and patients, highlighting the importance of patient selection based on IDO1 expression levels in clinical trials.

CANCER TREATMENT REVIEWS (2022)

Review Biochemistry & Molecular Biology

Targeting metastatic cancer

Karuna Ganesh et al.

Summary: Improved understanding of metastases biology has led to advancements in targeting and treating both micro- and macrometastases. Recent studies have identified the unique biology of metastasis-initiating cells, providing new opportunities for developing more effective treatment strategies through cancer sequencing, mechanistic studies, and clinical trials. These insights offer potential for better outcomes in targeting metastatic relapse and improving patient survival.

NATURE MEDICINE (2021)

Article Oncology

Effect of Taxane Chemotherapy With or Without Indoximod in Metastatic Breast Cancer A Randomized Clinical Trial

Veronica Mariotti et al.

Summary: In a prospective clinical trial, the addition of the IDO1 pathway inhibitor indoximod to a taxane did not improve progression-free survival in patients with ERBB2-negative metastatic breast cancer compared to a taxane alone. This study highlights the importance of exploring new treatment strategies for overcoming tumor immune suppression in breast cancer.

JAMA ONCOLOGY (2021)

Article Oncology

TDO2 Promotes the EMT of Hepatocellular Carcinoma Through Kyn-AhR Pathway

Lei Li et al.

Summary: Tryptophan 2,3-dioxygenase (TDO2) is implicated in the metastasis and invasion of hepatocellular carcinoma (HCC) by promoting epithelial to mesenchymal transition (EMT) through activating the Kyn-AhR pathway. Overexpression of TDO2 is correlated with advanced stage and malignant traits in HCC patients, while knockdown or inhibition of TDO2 suppresses migration and invasion of HCC cells.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Endocrinology & Metabolism

Quinolinate Phosphoribosyltransferase Promotes Invasiveness of Breast Cancer Through Myosin Light Chain Phosphorylation

Chien-Liang Liu et al.

Summary: This study demonstrated that upregulated QPRT expression in breast cancer enhances invasiveness through purinergic signaling, indicating that QPRT could potentially serve as a prognostic indicator and therapeutic target in breast cancer.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Oncology

Immune Checkpoint Inhibitors in Triple Negative Breast Cancer Treatment: Promising Future Prospects

Remy Thomas et al.

Summary: Immunotherapy, particularly immune checkpoint inhibitors, has revolutionized cancer treatment by leveraging a patient's own immune system to combat tumors. Triple negative breast cancer, as an immunogenic subtype, shows potential for positive responses to immunotherapy. Exploration of tumor characteristics and treatment strategies is crucial for enhancing the efficacy of immune checkpoint blockade in breast cancer treatment.

FRONTIERS IN ONCOLOGY (2021)

Article Pharmacology & Pharmacy

The Differential Selectivity of Aryl Hydrocarbon Receptor (AHR) Agonists towards AHR-Dependent Suppression of Mammosphere Formation and Gene Transcription in Human Breast Cancer Cells

Nao Saito et al.

Summary: The study showed that different AHR agonists have varying degrees of suppressive effects on mammosphere formation derived from breast cancer stem cells, which do not necessarily correlate with their abilities to induce AHR-mediated gene transcription. This suggests that different AHR functions may be differentially induced in an agonist-dependent manner.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2021)

Article Oncology

A Phase I Study of an IDO-1 Inhibitor (LY3381916) as Monotherapy and in Combination With an Anti-PD-L1 Antibody (LY3300054) in Patients With Advanced Cancer

Nuria Kotecki et al.

Summary: LY3381916 is a highly selective and potent inhibitor of indoleamine 2,3-dioxygenase 1, with potential in combination with PD-L1 inhibitors for advanced solid tumors. However, dose adjustments may be needed for optimal combination therapy efficacy based on preliminary data from this study.

JOURNAL OF IMMUNOTHERAPY (2021)

Article Health Care Sciences & Services

Integrated Molecular Characterization to Reveal the Association between Kynurenine 3-Monooxygenase Expression and Tumorigenesis in Human Breast Cancers

Yuk-Wah Tsang et al.

Summary: The study revealed that Kynurenine 3-monooxygenase (KMO) is highly expressed in various tumors, particularly in invasive ductal breast carcinoma, and positively correlated with malignant clinical features in breast cancer patients. The top ten KMO-correlated genes are chemokines and pro-inflammatory cytokines known to be involved in cancer progression, indicating that KMO may facilitate breast cancers by regulating inflammatory responses synergistically with these hub genes. These findings highlight the tumor-promoting role of KMO in breast cancers and suggest its potential as a biomarker for prognosis prediction.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Review Immunology

Detrimental activation of AhR pathway in cancer: an overview of therapeutic strategies

Delphine Leclerc et al.

Summary: Recent studies have shown that sustained activation of the AhR receptor promotes tumor growth and impairs immune defense, with the IL4I1 pathway presenting challenges for complete inhibition of AhR ligand production. Therapeutic strategies targeting the AhR signaling pathway and their potential adverse effects are being explored, with two phase I clinical trials investigating the use of AhR antagonists to reset the immune system and sensitize cancer cells to therapies.

CURRENT OPINION IN IMMUNOLOGY (2021)

Article Oncology

Anxiety and depression after breast cancer: The predictive role of monoamine levels

Joana Perez-Tejada et al.

Summary: This study aimed to investigate the predictive role of peripheral dopamine, noradrenaline, serotonin, and kynurenine in anxiety and depression among breast cancer survivors. The results showed that high kynurenine levels predicted both disorders, while low levels of noradrenaline and dopamine predicted anxiety and depression symptoms, respectively. Young women were found to be especially vulnerable to the detrimental effects of low dopamine and serotonin.

EUROPEAN JOURNAL OF ONCOLOGY NURSING (2021)

Article Genetics & Heredity

TDO2 knockdown inhibits colorectal cancer progression via TDO2-KYNU-AhR pathway

Long Zhao et al.

Summary: The study found that TDO2 expression level in colorectal cancer is associated with tumor clinical stage, with high expression correlating with poor outcome. Inhibition of TDO2 expression significantly reduces proliferation, migration, and invasion abilities of CRC cells.
Article Multidisciplinary Sciences

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

Cristina C. Clement et al.

Summary: 3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. The authors identify 3-HKA as a biogenic amine with anti-inflammatory properties, showing its protective effects against psoriasis and nephrotoxic nephritis in mice.

NATURE COMMUNICATIONS (2021)

Editorial Material Medicine, Research & Experimental

Monitoring the kynurenine system: Concentrations, ratios or what else?

Masaru Tanaka et al.

Summary: The tryptophan-kynurenine metabolic pathway is crucial in producing endogenous bioactive molecules, and its activation is linked to the pathogenesis of various diseases. Efforts have been made to calibrate the levels and ratios of kynurenines to identify biomarkers and diagnostic targets. This editorial discusses the interaction between biosystems and the kynurenine system, as well as potential measures to evaluate stress levels that may lead to illnesses.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2021)

Article Oncology

Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma

Yousef Zakharia et al.

Summary: The combination therapy of indoximod and pembrolizumab showed promising anti-tumor efficacy in advanced melanoma patients, especially in PD-L1 positive patients. The treatment was well tolerated with expected side effects similar to pembrolizumab alone.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer

Jin-Li Wei et al.

Summary: The study revealed a significant correlation between GCH1 expression and Tregs infiltration in TNBC, with high GCH1 expression associated with reduced overall survival. Experimental findings demonstrated that GCH1 increased Tregs infiltration, decreased apoptosis, and elevated PD-1-positive fraction. Metabolic reprogramming induced by GCH1 in tumor cells led to immunosuppression through IDO1 upregulation, with potential for immunometabolic strategy in TNBC.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

Surface Expression of Kynurenine 3-Monooxygenase Promotes Proliferation and Metastasis in Triple-Negative Breast Cancers

Min-Hua Lai et al.

Summary: Kynurenine 3-monooxygenase (KMO) is a key enzyme in the kynurenine pathway, located on the mitochondrial outer membrane. Dysregulation of KMO is associated with neurodegenerative diseases, but a study on canine mammary gland tumors (cMGT) found KMO can also be aberrantly expressed on cell membranes, indicating a potential therapeutic target for human breast cancers.

CANCER CONTROL (2021)

Review Oncology

Molecular Subtypes of Breast Cancer: A Review for Breast Radiologists

Karen S. Johnson et al.

Summary: Gene expression profiling has revolutionized the understanding of breast cancer, identifying four molecular subtypes with critical differences in clinical features, treatment response, and patient prognosis. Accurate identification and distinction between these subtypes is essential for guiding appropriate clinical management and improving outcomes for patients.

JOURNAL OF BREAST IMAGING (2021)

Article Biochemistry & Molecular Biology

Reliable chromatographic assay for measuring of indoleamine 2,3-dioxygenase 1 (IDO1) activity in human cancer cells

Ilona Sadok et al.

Summary: A new HPLC-DAD method for determining IDO1 activity in human cancer cells has been developed and successfully validated, demonstrating its applicability in different cancer cell types. This approach provides a useful model for studying the role of the kynurenine pathway in cancer biology.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)

Article Pathology

Gene expression of indoleamine and tryptophan dioxygenases and three long non-coding RNAs in breast cancer

Soudeh Ghafouri-Fard et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2020)

Article Oncology

Comprehensive Analysis of the Expression and Prognosis for TDO2 in Breast Cancer

Qiang Liu et al.

MOLECULAR THERAPY-ONCOLYTICS (2020)

Review Biochemistry & Molecular Biology

Searching for Peripheral Biomarkers in Neurodegenerative Diseases: The Tryptophan-Kynurenine Metabolic Pathway

Nora Torok et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, General & Internal

Breast cancer

Nadia Harbeck et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

Review Endocrinology & Metabolism

Molecular logic of mTORC1 signalling as a metabolic rheostat

Alexander J. Valvezan et al.

NATURE METABOLISM (2019)

Review Immunology

IDO1 in cancer: a Gemini of immune checkpoints

Lijie Zhai et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2018)

Review Chemistry, Medicinal

A patent review of IDO1 inhibitors for cancer

Jae Eun Cheong et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2018)

Review Immunology

The Aryl Hydrocarbon Receptor and Tumor immunity

Ping Xue et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Pharmacology & Pharmacy

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor

Benjamin J. Moyer et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)

Article Oncology

Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer

Daniel E. Carvajal-Hausdorf et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)

Article Oncology

Breast Cancer: Multiple Subtypes within a Tumor?

Syn Kok Yeo et al.

TRENDS IN CANCER (2017)

Article Neurosciences

Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects

Abdulla A-B Badawy

INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH (2017)

Review Immunology

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

David H. Munn et al.

TRENDS IN IMMUNOLOGY (2016)

Article Medicine, General & Internal

Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer

Edward B. Garon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Biochemistry & Molecular Biology

The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells

Kanae Bekki et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2015)

Article Endocrinology & Metabolism

Levels in neurotransmitter precursor amino acids correlate with mental health in patients with breast cancer

K. Huefner et al.

PSYCHONEUROENDOCRINOLOGY (2015)

Review Oncology

Treatment of HER2-positive breast cancer

Maria Cristina Figueroa-Magalhaes et al.

BREAST (2014)

Article Multidisciplinary Sciences

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

Alban Bessede et al.

NATURE (2014)

Article Multidisciplinary Sciences

Involvement of the Kynurenine Pathway in Human Glioma Pathophysiology

Seray Adams et al.

PLOS ONE (2014)

Article Oncology

A joint analysis of metabolomics and genetics of breast cancer

Xiaohu Tang et al.

BREAST CANCER RESEARCH (2014)

Article Oncology

Biological subtypes of breast cancer: Prognostic and therapeutic implications

Ozlem Yersal et al.

WORLD JOURNAL OF CLINICAL ONCOLOGY (2014)

Review Oncology

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion

Michael Platten et al.

CANCER RESEARCH (2012)

Article Radiology, Nuclear Medicine & Medical Imaging

Tryptophan metabolism in breast cancers: molecular imaging and immunohistochemistry studies

Csaba Juhasz et al.

NUCLEAR MEDICINE AND BIOLOGY (2012)

Article Multidisciplinary Sciences

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Luc Pilotte et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Oncology

IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development

Courtney Smith et al.

CANCER DISCOVERY (2012)

Review Biochemistry & Molecular Biology

Structure, mechanism, and substrate specificity of kynureninase

Robert S. Phillips

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2011)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Oncology

Deconstructing the molecular portraits of breast cancer

Aleix Prat et al.

MOLECULAR ONCOLOGY (2011)

Article Multidisciplinary Sciences

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Christiane A. Opitz et al.

NATURE (2011)

Article Medicine, General & Internal

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

F. Stephen Hodi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Multidisciplinary Sciences

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

Nam Trung Nguyen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Neurosciences

On the Biological Importance of the 3-hydroxyanthranilic Acid: Anthranilic Acid Ratio

L. Gail Darlington et al.

INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH (2010)

Article Biochemistry & Molecular Biology

Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway

Helen J. Ball et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo

Laura Amori et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Article Oncology

Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer

Maggie C. U. Cheang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2009)

Review Immunology

The aryl hydrocarbon receptor in immunity

Charlotte Esser et al.

TRENDS IN IMMUNOLOGY (2009)

Article Biotechnology & Applied Microbiology

Immune system modulation in patients with malignant and benign breast disorders: tryptophan degradation and serum neopterin

Gozde Girgin et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2009)

Review Biochemistry & Molecular Biology

Immune escape as a fundamental trait of cancer: focus on IDO

G. C. Prendergast

ONCOGENE (2008)

Article Multidisciplinary Sciences

3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis

Tolmoko Hayashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Microbiology

Tryptophan catabolism: Identification and characterization of a new degradative pathway

KL Colabroy et al.

JOURNAL OF BACTERIOLOGY (2005)

Review Biochemistry & Molecular Biology

The role of IFN-gamma and TNF-alpha-responsive regulatory elements in the synergistic induction of indoleamine dioxygenase

CM Robinson et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2005)

Article Immunology

Regulatory T cells mediate maternal tolerance to the fetus

VR Aluvihare et al.

NATURE IMMUNOLOGY (2004)

Article Biochemistry & Molecular Biology

Indoleamine 2,3-dioxygenase activity and L-tryptophan transport in human breast cancer cells

MT Travers et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2004)

Article Multidisciplinary Sciences

Breast cancer classification and prognosis based on gene expression profiles from a population-based study

C Sotiriou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Cell Biology

Tryptophan and the immune response

JR Moffett et al.

IMMUNOLOGY AND CELL BIOLOGY (2003)

Article Biochemistry & Molecular Biology

T cell apoptosis by tryptophan catabolism

I Fallarino et al.

CELL DEATH AND DIFFERENTIATION (2002)

Article Biochemistry & Molecular Biology

Heme: A regulator of rat hepatic tryptophan 2,3-dioxygenase?

SY Ren et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2000)