Characterising biological mechanisms underlying ethnicity-associated outcomes in COVID-19 through biomarker trajectories: a multicentre registry analysis

Article Medicine, General & Internal

Biomarker identification using dynamic time warping analysis: a longitudinal cohort study of patients with COVID-19 in a UK tertiary hospital

Hannah Burke et al.

Summary: This retrospective observational report describes the longitudinal changes in laboratory prognostic variables in relation to disease progression in hospitalised patients with COVID-19.

BMJ OPEN (2022)

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Article Biochemical Research Methods

Longitudinally monitored immune biomarkers predict the timing of COVID-19 outcomes

Gorka Lasso et al.

PLoS Computational Biology (2022)

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Article Anesthesiology

Prevalence, characteristics, and longer-term outcomes of patients with persistent critical illness attributable to COVID-19 in Scotland: a national cohort study

Michael C. Blayney et al.

Summary: This study investigated the prevalence, risk factors, and long-term outcomes of persistent critical illness in patients with COVID-19. The results showed that almost half of the COVID-19 patients admitted to critical care developed persistent critical illness, utilizing a significant amount of critical care resources. However, persistent critical illness was not associated with significantly worse long-term outcomes compared to patients with shorter illness duration.

BRITISH JOURNAL OF ANAESTHESIA (2022)

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Article Critical Care Medicine

Catabolism in Critical Illness: A Reanalysis of the REducing Deaths due to OXidative Stress (REDOXS) Trial*

Ryan W. Haines et al.

Summary: The catabolic phenotype measured by increased urea-to-creatinine ratio is associated with increased risk of death during prolonged ICU stay. Glutamine supplementation increases the urea-to-creatinine ratio and therefore increases the risk of death.

CRITICAL CARE MEDICINE (2022)

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Article Multidisciplinary Sciences

Ethnic disparities in hospitalisation and hospital-outcomes during the second wave of COVID-19 infection in east London

Y. Wan et al.

Summary: It remains unclear whether changes in public behaviors, developments in COVID-19 treatments, improved patient care, and directed policy initiatives have affected outcomes for minority ethnic groups in the second pandemic wave. This study analyzed patients admitted to acute NHS hospitals in east London with SARS-CoV-2 infection between September 1st, 2020 and February 17th, 2021. The results showed that Asian and Black populations experienced higher rates of age-standardized hospital admission compared to the White population. Asian patients also had a significantly higher risk of death within 30 days. This suggests a higher overall risk of COVID-19-associated death in Asian and Black communities.

SCIENTIFIC REPORTS (2022)

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Article Virology

Predictive values of blood urea nitrogen/creatinine ratio and other routine blood parameters on disease severity and survival of COVID-19 patients

Fesih Ok et al.

Summary: The study identified that the blood urea nitrogen/creatinine ratio and neutrophil to lymphocyte ratio are independent predictors for the severity and survival of COVID-19. Routine evaluation of these parameters can help in identifying high-risk cases with COVID-19.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Review Biotechnology & Applied Microbiology

Prognostic association of routinely measured biomarkers in patients admitted to critical care: a systematic review

Yize I. Wan et al.

Summary: This study examined 128 studies and found associations between parameters like red cell distribution width, neutrophil-to-lymphocyte ratio, C-reactive protein, and platelet count with mortality and length of stay in critical care patients. Most studies used regression modeling, but none validated the proposed predictive models.

BIOMARKERS (2021)

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Article Immunology

Longitudinal Profile of Laboratory Parameters and Their Application in the Prediction for Fatal Outcome Among Patients Infected With SARS-CoV-2: A Retrospective Cohort Study

Hao-Long Zeng et al.

Summary: The study conducted a retrospective cohort study on 642 patients with COVID-19 in a designated hospital in Wuhan, China, determining 3 clinical stages and analyzing laboratory parameters and cytokines at each stage. The findings indicate that factors such as age, lactate dehydrogenase, procalcitonin, lymphocyte count, and interleukin 6 play crucial roles in predicting fatal outcomes for COVID-19 patients.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Cell Biology

The Impact of COVID-19 Disease on Platelets and Coagulation

Geoffrey D. Wool et al.

Summary: COVID-19 infection can lead to a proinflammatory state and abnormalities in the coagulation mechanism, with patients often experiencing thrombosis. Elevated levels of D-dimer are positively correlated with mortality, and patients typically exhibit mild thrombocytopenia.

PATHOBIOLOGY (2021)

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Review Hematology

COVID-19 and hematology findings based on the current evidences: A puzzle with many missing pieces

Mehdi Karimi Shahri et al.

Summary: The novel coronavirus COVID-19 has spread globally, infecting millions and causing numerous deaths. Studies have shown that hematological abnormalities in COVID-19 patients may indicate disease severity, with thrombocytopenia being associated with poor prognosis. Accurate evaluation of laboratory indicators can help guide appropriate treatment and care for COVID-19 patients.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2021)

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Article Medicine, General & Internal

Ethnicity and outcomes in patients hospitalised with COVID-19 infection in East London: an observational cohort study

Vanessa J. Apea et al.

Summary: The study found that COVID-19 patients of Asian and black backgrounds had higher mortality rates despite controlling for all confounders and frailty. These patients were more likely to be admitted to the ICU and receive invasive ventilation, indicating greater disease severity.

BMJ OPEN (2021)

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Article Biology

Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

Jack Gisby et al.

Summary: Analysis of blood samples from ESKD patients with COVID-19 revealed protein markers associated with clinical severity, including epithelial damage, immune activation, and cell-cell interactions, providing potential drug targets.

ELIFE (2021)

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Letter Oncology

Thrombocytosis in COVID-19 patients without myeloproliferative neoplasms is associated with better prognosis but higher rate of venous thromboembolism

Marko Lucijanic et al.

BLOOD CANCER JOURNAL (2021)

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Article Public, Environmental & Occupational Health

Outcome-Stratified Analysis of Biomarker Trajectories for Patients Infected With Severe Acute Respiratory Syndrome Coronavirus 2

Mary G. Bowring et al.

Summary: This study analyzed the longitudinal trajectories of vital signs and biomarkers in COVID-19 patients, identifying distinct patterns leading up to different outcomes such as discharge and death. The findings can contribute to a better understanding of disease progression and could potentially help in predicting patient outcomes based on clinical data.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2021)

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Article Public, Environmental & Occupational Health

Unequal impact of the COVID-19 crisis on minority ethnic groups: a framework for understanding and addressing inequalities

Srinivasa Vittal Katikireddi et al.

Summary: The COVID-19 pandemic has disproportionately affected minority ethnic groups, with inequalities arising through six pathways: differential exposure to the virus, vulnerability to infection/disease, health consequences, social consequences, effectiveness of control measures, and adverse consequences of control measures. Current research only partially understands these pathways, highlighting the need for further investigation into the complex interplay of social and biological factors in ethnic inequalities.

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH (2021)

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Article Medicine, General & Internal

Disparities in COVID-19 Outcomes by Race, Ethnicity, and Socioeconomic Status A Systematic-Review and Meta-analysis

Shruti Magesh et al.

Summary: This study found that members of racial and ethnic minority groups had higher risks of COVID-19 positivity and disease severity. Furthermore, socioeconomic determinants were strongly associated with COVID-19 outcomes in racial and ethnic minority populations.

JAMA NETWORK OPEN (2021)

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Article Medicine, General & Internal

Ethnicity and acute hospital admissions: Multi-center analysis of routine hospital data

Yize I. Wan et al.

Summary: This study examined the impact of ethnic and social disparities on acute healthcare outcomes, revealing that non-white patients were younger and more likely to be admitted to the hospital, with a lower mortality risk compared to white patients. However, deprivation was associated with increased mortality in all ethnic groups.

ECLINICALMEDICINE (2021)

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Review Medicine, General & Internal

Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis

Preeti Malik et al.

Summary: This study found a significant association between lymphopenia, thrombocytopenia, and elevated levels of CRP, PCT, LDH, D-dimer, and COVID-19 severity. These results have the potential to be used as early biomarkers to improve the management of COVID-19 patients by identifying high-risk patients and allocating healthcare resources appropriately in the pandemic.

BMJ EVIDENCE-BASED MEDICINE (2021)

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Article Public, Environmental & Occupational Health

Thrombocytopenia as a prognostic marker in COVID-19 patients: diagnostic test accuracy meta-analysis

Raymond Pranata et al.

Summary: Thrombocytopenia was found to be associated with poor outcome in patients with COVID-19, including mortality and severity. Meta-analysis also showed a significant relationship between thrombocytopenia and composite poor outcome.

EPIDEMIOLOGY AND INFECTION (2021)

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Letter Virology