期刊
BMC MUSCULOSKELETAL DISORDERS
卷 24, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12891-023-06433-7
关键词
Knee osteoarthritis; Radiomics; Infrapatellar fat pad; Magnetic resonance imaging
This study evaluated the infrapatellar fat pad (IFP) in knee osteoarthritis (KOA) using radiomics and developed a radiomic signature for assessing IFP in KOA progression. The results showed that radiomic alterations in IFP were associated with the severity and structural abnormalities of KOA.
BackgroundThe infrapatellar fat pad (IFP) may have bilateral influence on knee osteoarthritis (KOA). IFP evaluation may be a key contributor to the diagnostic and clinical management of KOA. Few studies have evaluated KOA-related IFP alteration with radiomics. We investigated radiomic signature for the assessment of IFP for KOA progression in older adults.MethodsA total of 164 knees were enrolled and grouped based on Kellgren-Lawrence (KL) scoring. MRI-based radiomic features were calculated from IFP segmentation. The radiomic signature was developed using the most predictive subset of features and the machine-learning algorithm with minimum relative standard deviation. KOA severity and structure abnormality were assessed using a modified whole-organ magnetic resonance imaging score (WORMS). The performance of the radiomic signature was evaluated and the correlation with WORMS assessments was analyzed.ResultsThe area under the curve of the radiomic signature for diagnosing KOA was 0.83 and 0.78 in the training and test datasets, respectively. Rad-scores were 0.41 and 2.01 for the training dataset in the groups with and without KOA (P < 0.001) and 0.63 and 2.31 for the test dataset (P = 0.005), respectively. WORMS significantly and positively correlated with rad-scores.ConclusionsThe radiomic signature may be a reliable biomarker to detect IFP abnormality of KOA. Radiomic alterations in IFP were associated with severity and knee structural abnormalities of KOA in older adults.
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