4.5 Article

Health-related quality of life of men with primary osteoporosis and its changes after bisphosphonates treatment

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BMC MUSCULOSKELETAL DISORDERS
卷 24, 期 1, 页码 -

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BMC
DOI: 10.1186/s12891-023-06397-8

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Osteoporosis; Males; HRQoL; SF-36; Bisphosphonates

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Men with osteoporosis have significantly impaired health-related quality of life, and the severity of osteoporosis is negatively correlated with quality of life. Fragility fracture is an important factor contributing to decreased quality of life. Treatment with bisphosphonates can improve the health-related quality of life in men with osteopenia/osteoporosis.
IntroductionOsteoporosis leads to more serious consequences in men than in women, but less is known about its impacts on health-related quality of life (HRQoL) of men, and whether the anti-osteoporosis treatment can improve HRQoL of men with osteopenia/osteoprosis.MethodsWe enrolled men with primary osteoporosis and age-matched healthy controls. We collected medical history, serum levels of carboxyl-terminal type I collagen telopeptide, procollagen type I propeptides, and bone mineral density of patients. All patients and controls completed the short-form 36 (SF-36) questionnaires. Changes in HRQoL of osteopenia/osteoporosis men were prospectively evaluated after alendronate or zoledronic acid treatment.ResultsA total of 100 men with primary osteoporosis or osteopenia and 100 healthy men were included. The patients were divided into three subgroups: osteopenia (n = 35), osteoporosis (n = 39) and severe osteoporosis (n = 26). Men with osteoporosis or severe osteoporosis had impaired HRQoL in domains of physical health compared to healthy controls. HRQoL scores in physical health related domains of patients with severe osteoporosis were significantly lower compared to healthy controls, and were the poorest among the three subgroups of patients. Fragility fracture history was correlated with lower SF-36 scores about physical health. In 34 men with newly diagnosed osteoporosis receiving bisphosphonates treatment, HRQoL scores were significantly improved in domains of physical health after treatments.ConclusionsThe HRQoL is significantly impaired in men with osteoporosis, and the more severe the osteoporosis, the poorer the HRQoL. Fragility fracture is an important influencing factor of deteriorated HRQoL. Bisphosphonates treatment is beneficial to improve HRQoL of osteopenia/osteoporosis men.

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