4.6 Article

Analysis of connexin 43, connexin 45 and N-cadherin in the human sertoli cell line FS1 and the human seminoma-like cell line TCam-2 in comparison with human testicular biopsies

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On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro *

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Summary: GCNIS is the noninvasive precursor of testicular germ cell tumors type II, originating from embryonic germ cells blocked in their maturation. The impaired Sertoli cells associated with GCNIS are theorized to be prepubertal cells arrested in maturation due to (epi)genetic anomalies and/or environmental antiandrogens, leading to a maturational block and progression into GCNIS. Immunochemical and ultrastructural studies support the hypothesis that GCNIS-associated Sertoli cells represent adult cells undergoing progressive dedifferentiation.

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