☆ 4.6 Article

Integrated analysis of the relation to tumor immune microenvironment and predicted value of Stonin1 gene for immune checkpoint blockage and targeted treatment in kidney renal clear cell carcinoma

BMC CANCER (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

The reversion of DNA methylation-induced miRNA silence via biomimetic nanoparticles-mediated gene delivery for efficient lung adenocarcinoma therapy

Lu Liang et al.

Summary: Researchers have developed novel biomimetic nanoparticles activated by matrix metalloproteinase 2 (MMP2) to effectively deliver miRNA to lung cancer cells. These nanoparticles, camouflaged with red blood cell (RBC) membranes, have the advantages of extended circulation time, lower toxicity, better biocompatibility, and immune escape. In vitro and in vivo experiments have demonstrated the ability of these nanoparticles to induce apoptosis in lung cancer cells and inhibit the development and progression of lung adenocarcinoma by targeting ADAM9.

MOLECULAR CANCER (2022)

添加到收藏夹

Review Oncology

Varied functions of immune checkpoints during cancer metastasis

Ali Safarzadeh et al.

Summary: Immune checkpoints, including both inhibitory and costimulatory molecules, play crucial roles in regulating the immune system and hindering the development of malignancies. Inhibitory immune checkpoints are associated with increased metastatic tumors, while activating costimulatory immune checkpoints can restrain tumor metastasis. The targeting of these immune checkpoints presents novel therapeutic opportunities for cancer treatment in the future.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

添加到收藏夹

Review Oncology

The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker

Denis L. Jardim et al.

Summary: Tumor mutational burden (TMB) reflects cancer mutation quantity and correlates with better outcomes of immune checkpoint inhibitors (ICIs). However, TMB as a biomarker is imperfect and a composite predictor including critical variables is needed.

CANCER CELL (2021)

添加到收藏夹

Article Oncology

Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer

Milena Hornburg et al.

Summary: This study provides a detailed analysis of distinct T cell infiltration patterns in ovarian tumors, revealing the impact on responses to cancer immunotherapies and the underlying key determinants and biology of tumor immune phenotypes. The research highlights potential molecular mechanisms shaping these phenotypes and may inform therapeutic strategies for enhancing clinical benefit from cancer immunotherapies.

CANCER CELL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Pancancer survival analysis of cancer hallmark genes

Adam Nagy et al.

Summary: This study aimed to estimate the prognostic effect of cancer hallmark genes in multiple distinct cancer types. The results showed significant heterogeneity and tissue specificity in the correlation between these genes and survival, providing valuable information for future targeted therapy development in solid tumors.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Three-Dimensional Genome Interactions Identify Potential Adipocyte Metabolism-Associated Gene STON1 and Immune-Correlated Gene FSHR at the rs13405728 Locus in Polycystic Ovary Syndrome

Can-hui Cao et al.

Summary: In this study, STON1 and FSHR were identified as potential targets of the rs13405728 locus, with a high expression in PCOS patients and association with adipocyte metabolism and CD4 immune expression. The findings provide insight into the pathogenesis of PCOS through 3D genomic interactions.

FRONTIERS IN ENDOCRINOLOGY (2021)

添加到收藏夹

Review Immunology

Human Anti-tumor Immunity: Insights from Immunotherapy Clinical Trials

Jackson G. Egen et al.

IMMUNITY (2020)

添加到收藏夹

Article Genetics & Heredity

mRNAsi Index: Machine Learning in Mining Lung Adenocarcinoma Stem Cell Biomarkers

Yitong Zhang et al.

GENES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

Bo Zhang et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Letter Biotechnology & Applied Microbiology

Visualizing and interpreting cancer genomics data via the Xena platform

Mary J. Goldman et al.

NATURE BIOTECHNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

TIMER2.0 for analysis of tumor-infiltrating immune cells

Taiwen Li et al.

NUCLEIC ACIDS RESEARCH (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Immunomodulatory Roles of VEGF Pathway Inhibitors in Renal Cell Carcinoma

Laure Hirsch et al.

DRUGS (2020)

添加到收藏夹

Review Immunology

Cancer Stem Cells-Origins and Biomarkers: Perspectives for Targeted Personalized Therapies

Lia Walcher et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer

Melanie Desbois et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Oncology

ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach

C. Luchini et al.

ANNALS OF ONCOLOGY (2019)

添加到收藏夹

Review Immunology

Targeting Treg cells in cancer immunotherapy

Atsushi Tanaka et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2019)

添加到收藏夹

Review Oncology

Tumor Microenvironment Dynamics in Clear-Cell Renal Cell Carcinoma

Lynda Vuong et al.

CANCER DISCOVERY (2019)

添加到收藏夹

Article Oncology

Cancer statistics, 2019

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

添加到收藏夹

Article Immunology

LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers

Jing-Hua Pan et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Medicine, General & Internal

Sunitinib Alone or after Nephrectomy in Metastatic Renal-Cell Carcinoma

A. Mejean et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Article Medicine, General & Internal

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

R. J. Motzer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Article Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

添加到收藏夹

Article Oncology

TIP: A Web Server for Resolving Tumor Immunophenotype Profiling

Liwen Xu et al.

CANCER RESEARCH (2018)

添加到收藏夹

Article Multidisciplinary Sciences

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan et al.

NATURE (2018)

添加到收藏夹

Review Oncology

Renal Cell Carcinoma in the Era of Precision Medicine: From Molecular Pathology to Tissue-Based Biomarkers

Sabina Signoretti et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

添加到收藏夹

Review Immunology

The diverse functions of the PD1 inhibitory pathway

Arlene H. Sharpe et al.

NATURE REVIEWS IMMUNOLOGY (2018)

添加到收藏夹

Review Multidisciplinary Sciences

Elements of cancer immunity and the cancer-immune set point

Daniel S. Chen et al.

NATURE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

Zefang Tang et al.

NUCLEIC ACIDS RESEARCH (2017)

添加到收藏夹

Article Oncology

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

Darshan S. Chandrashekar et al.

NEOPLASIA (2017)

添加到收藏夹

Article Medicine, General & Internal

Renal cell carcinoma

James J. Hsieh et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

添加到收藏夹

Review Oncology

Treatment of renal cell carcinoma: Current status and future directions

Pedro C. Barata et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2017)

添加到收藏夹

Article Oncology

TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells

Taiwen Li et al.

CANCER RESEARCH (2017)

添加到收藏夹

Review Oncology

Microsatellite Instability as a Biomarker for PD-1 Blockade

Jonathan C. Dudley et al.

CLINICAL CANCER RESEARCH (2016)

添加到收藏夹

Article Urology & Nephrology

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours

Holger Moch et al.

EUROPEAN UROLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility

Fabian Feutlinske et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Review Medicine, General & Internal

Renal cell carcinoma

Eric Jonasch et al.

BMJ-BRITISH MEDICAL JOURNAL (2014)

添加到收藏夹

Review Immunology

Oncology Meets Immunology: The Cancer-Immunity Cycle

Daniel S. Chen et al.

IMMUNITY (2013)

添加到收藏夹

Article Oncology

Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial

Thomas E. Hutson et al.

LANCET ONCOLOGY (2013)

添加到收藏夹

Article Oncology

An immune-active tumor microenvironment favors clinical response to ipilimumab

Rui-Ru Ji et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2012)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Genome wide analysis reveals association of a FTO gene variant with epigenetic changes

Markus Sallman Almen et al.

GENOMICS (2012)

添加到收藏夹

Editorial Material Oncology

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

Ethan Cerami et al.

CANCER DISCOVERY (2012)

添加到收藏夹

Review Cell Biology

Stonins - Specialized Adaptors for Synaptic Vesicle Recycling and Beyond?

Tanja Maritzen et al.

TRAFFIC (2010)

添加到收藏夹

Article Oncology

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

David G. DeNardo et al.

CANCER CELL (2009)

添加到收藏夹

Article Oncology

Randomized Phase II Trial of First-Line Treatment With Sorafenib Versus Interferon Alfa-2a in Patients With Metastatic Renal Cell Carcinoma

Bernard Escudier et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

添加到收藏夹

Review Immunology

Multiple roles for CD4(+) T cells in anti-tumor immune responses

Richard Kennedy et al.

IMMUNOLOGICAL REVIEWS (2008)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Common and uncommon histologic subtypes of renal cell carcinoma: Imaging spectrum with pathologic correlation

Srinivasa R. Prasad et al.

RADIOGRAPHICS (2006)

添加到收藏夹

Article Cell Biology

Stonin 2: An adaptor-like protein that interacts with components of the endocytic machinery

JA Martina et al.

JOURNAL OF CELL BIOLOGY (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.