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Assessment of hypertension-mediated organ damage in children and adolescents with hypertension

BLOOD PRESSURE (2023)

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Summary: Objective: This systematic review and meta-analysis evaluated left ventricular systolic and diastolic function in children and adolescents with primary hypertension. The results showed that hypertensive children and adolescents had increased heart rate and fractional shortening, but no difference in ejection fraction. They also exhibited lower E/A values, higher E/e' values, and greater global longitudinal stress compared to normotensive controls.

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Isolated systolic hypertension is associated with increased left ventricular mass index and aortic stiffness in adolescents: a cardiac magnetic resonance study

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Summary: The clinical significance of isolated systolic hypertension (ISH) among hypertensive adolescents is still undetermined. In this study, cardiac magnetic resonance was used to evaluate a group of suspected primary hypertension patients, and it was found that ISH patients had more pronounced markers of cardiac end-organ damage, higher aortic stiffness, and stroke volume.

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Summary: This study derived carotid intima media thickness (CIMT) percentiles using improved technology and statistical techniques, and found an association between CIMT and hypertensive blood pressure (BP) and obesity in a population-based sample of adolescents and young adults.

HYPERTENSION (2022)

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Review Peripheral Vascular Disease

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Karolis Azukaitis et al.

Summary: This study aimed to investigate the early effects and independent determinants of arterial structure and function in children and young people with primary hypertension. The results revealed that elevated blood pressure was associated with higher carotid-femoral pulse wave velocity (cfPWV) and carotid intima-media thickness (cIMT), while body mass index (BMI) showed weaker associations. Improvement in carotid wall cross-sectional area (WCSA) was associated with a decrease in measures of central obesity.

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Prevalence of left ventricular hypertrophy in children and young people with primary hypertension: Meta-analysis and meta-regression

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Summary: Left ventricular hypertrophy (LVH) is a main marker of hypertensive organ damage (HMOD) in children and young people (CYP) with primary hypertension(PH). A meta-analysis of CYP with PH was conducted and it was found that the overall prevalence of LVH was 30.5%, with a predominant pattern of eccentric LVH. Increased BMI was identified as the most significant risk factor for LVH in hypertensive youth.

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Evolution of isolated systolic hypertension with normal central blood pressure in adolescents-prospective study

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Remodeling of Retinal Microcirculation Is Associated With Subclinical Arterial Injury in Hypertensive Children

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Blood Pressure and Cognitive Function in Children and Adolescents

Marc B. Lande et al.

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Isolated systolic hypertension of the young and its association with central blood pressure in a large multi-ethnic population. The HELIUS study

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Effects of Obesity and Hypertension on Pulse Wave Velocity in Children

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Hemodynamic and Mechanical Properties of the Proximal Aorta in Young and Middle-Aged Adults With Isolated Systolic Hypertension The Dallas Heart Study

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Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance The Young Finns Study

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Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents

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M Litwin et al.

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