☆ 4.6 Review

Advances in bioreactor control for production of biotherapeutic products

BIOTECHNOLOGY AND BIOENGINEERING (2023)

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Article Biotechnology & Applied Microbiology

Cole-Cole modeling of real-time capacitance data for estimation of cell physiological properties in recombinant Escherichia coli cultivation

Nivedhitha Swaminathan et al.

Summary: This study explores the application of dielectric spectroscopy to estimate physiological properties, such as cell diameter and viable cell concentration, during recombinant protein production. The Cole-Cole model predicted the cell diameter and VCC with relatively low errors, enabling real-time process decisions for desired productivity and product quality.

BIOTECHNOLOGY AND BIOENGINEERING (2022)

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Article Biotechnology & Applied Microbiology

Using MVDA with stoichiometric balances to optimize amino acid concentrations in chemically defined CHO cell culture medium for improved culture performance

Taha Salim et al.

Summary: In this study, the utilization of multivariate data analytics (MVDA) coupled with amino acid stoichiometric balances (SBs) was demonstrated to increase cell growth and monoclonal antibody (mAb) productivity in efforts to support CD media development. Stoichiometric balances measure the difference between theoretical demand of amino acids and empirically measured fluxes to identify various catabolic or anabolic states of the cell, resulting in a 55% increase in total cell growth and about an 80% increase in total mAb productivity through optimized CD media.

BIOTECHNOLOGY AND BIOENGINEERING (2022)

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Article Biotechnology & Applied Microbiology

Comparison of partial least square, artificial neural network, and support vector regressions for real-time monitoring of CHO cell culture processes using in situ near-infrared spectroscopy

Daniel A. Zavala-Ortiz et al.

Summary: Research indicates that spectroscopic models based on ANNR and SVR show superior performance in cell culture monitoring, with better management of inter-batch heterogeneity and enhanced specificity. PLSR performs less effectively, while SVR and ANNR models show better results for all monitored parameters such as glucose.

BIOTECHNOLOGY AND BIOENGINEERING (2022)

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Article Biochemical Research Methods

Real-time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using Raman spectroscopy

Julia Domjan et al.

Summary: This paper introduces an innovative monitoring and control system based on Raman spectroscopy, which enables real-time measurement of nutrient concentrations in cell culture and the design of dynamic feeding strategies to maintain an ideal level, providing a more balanced environment and economic benefits.

BIOTECHNOLOGY JOURNAL (2022)

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Article Biotechnology & Applied Microbiology

Raman based chemometric model development for glycation and glycosylation real time monitoring in a manufacturing scale CHO cell bioreactor process

Luke A. Gibbons et al.

Summary: The QbD approach emphasizes understanding the production process for therapeutic mAbs to maintain product quality; Current methods for measuring CQAs are time and resource intensive, while PAT tools can provide real time measurements and align with QbD approach. Models developed with PAT tools showed good performance at small scale, but higher error rates at manufacturing scale suggest scale as a key consideration.

BIOTECHNOLOGY PROGRESS (2022)

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Article Energy & Fuels

Multi-objective optimization of monoclonal antibody production in bioreactor

Deepak Kumar et al.

Summary: This study developed a mathematical model to predict and optimize the production of monoclonal antibodies, and used optimization algorithms to find the optimal operating conditions for increased yield. The study also compared the effectiveness of different flow strategies in continuous production.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2022)

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Article Biotechnology & Applied Microbiology

On-line monitoring of industrial interest Bacillus fermentations, using impedance spectroscopy

Adrian Diaz Pacheco et al.

Summary: Impedance spectroscopy is a useful technique for characterizing electrochemical systems and monitoring cell cultures. This study used impedance spectroscopy to monitor batch fermentations of different Bacillus species and identified fixed frequencies that corresponded to different fermentation phases based on correlations with kinetic profiles.

JOURNAL OF BIOTECHNOLOGY (2022)

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Review Medicine, Research & Experimental

Harnessing the potential of machine learning for advancing Quality by Design in biomanufacturing

Ian Walsh et al.

Summary: Ensuring consistent high yields and product quality is a key challenge in biomanufacturing. Machine learning approaches have the potential to identify the impact of critical process parameters on product quality, enabling rational design and control of bioprocesses.

MABS (2022)

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Review Biotechnology & Applied Microbiology

Enablers of continuous processing of biotherapeutic products

Anurag S. Rathore et al.

Summary: Continuous processing is widely acknowledged in the biopharmaceutical industry for its higher productivity and greater consistency in product quality compared to batch manufacturing. Technology enablers play a crucial role in the transition from batch to continuous processing, including new bioreactors, cell retention devices, continuous flow refolding, continuous chromatography, and single-pass filtration systems.

TRENDS IN BIOTECHNOLOGY (2022)

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Article Engineering, Chemical

Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes

Sebastian Juan Reyes et al.

Summary: The growing biopharmaceutical industry has enabled the monitoring of key variables for process characterization and outcome predictions. Technological innovation in sensing technologies allows for continuous online monitoring of quality attributes, leading to improved process control and outcome prediction. This paper reviews state-of-the-art sensing technologies and their applications in cell culture monitoring, emphasizing the push towards industry 4.0 and smart manufacturing in the biopharmaceutical sector.

PROCESSES (2022)

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Article Engineering, Chemical

Advances in Bioreactor Systems for the Production of Biologicals in Mammalian Cells

Rajesh Sharma et al.

Summary: This paper focuses on evaluating the engineering aspects of currently available bioreactor designs and their suitability for mammalian cell cultures, aiming to find a comprehensive design that is suitable for a wide variety of cell lines, can produce high-yielding products at low cost and risk, in the shortest span of time.

CHEMBIOENG REVIEWS (2022)

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Article Chemistry, Analytical

Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-Linked Glycosylation

Aron Gyorgypal et al.

Summary: The biopharmaceutical industry is adopting continuous biomanufacturing practices and advanced process analytical technology to improve flexibility and efficiency in production. N-GLYcanyzer, an online sequential-injection-based PAT system, has been developed to monitor mAb glycosylation during biomanufacturing, allowing for real-time analysis and optimization.

ANALYTICAL CHEMISTRY (2022)

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Article Engineering, Chemical

Predicting the hydrodynamic properties of a bioreactor: Conditional density estimation as a surrogate model for CFD simulations

Umut Kaya et al.

Summary: The rising demands in biopharmaceutical manufacturing call for a deep understanding of the underlying bioprocesses, which can be achieved through computational fluid dynamics (CFD) simulations. This approach allows for the prediction of hydrodynamics properties and process design. However, CFD simulations are computationally demanding and limited to a small set of input parameters. To address this limitation, the proposed approach offers a computationally tractable model that can interpolate the volume-averaged distributions of hydrodynamic properties, providing a balance between the expressiveness of a CFD simulation and a basic regression model.

CHEMICAL ENGINEERING RESEARCH & DESIGN (2022)

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Article Biochemical Research Methods

Demonstration of a compact deep UV Raman spatial heterodyne spectrometer for biologics analysis

Michael Foster et al.

Summary: This paper introduces a new deep UV Raman instrument that can provide high specificity and accuracy for biopharmaceutical products, with the potential for online measurement.

JOURNAL OF BIOPHOTONICS (2022)

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Article Biochemical Research Methods

Real-time monitoring of antibody quality attributes for cell culture production processes in bioreactors via integration of an automated sampling technology with multi-dimensional liquid chromatography mass spectrometry

Sanket Dahotre et al.

Summary: The development of technologies to enable online monitoring of quality attributes (QAs) within bioreactors has been challenging. This study presents a fully automated and highly flexible method for direct monitoring of QAs using an automated sampling system and mD LC-MS/MS technology. The method allows for real-time quantification of post-translational modifications (PTMs) and making process decisions based on the resulting data, showing potential for monitoring multiple attributes.

JOURNAL OF CHROMATOGRAPHY A (2022)

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Article Biotechnology & Applied Microbiology

A Novel Approach for Non-Invasive Continuous In-Line Control of Perfusion Cell Cultivations by Raman Spectroscopy

A. Graf et al.

Summary: Continuous manufacturing is gaining importance in the biopharmaceutical industry for its efficiency, flexibility, and potential to produce higher and more consistent product quality. However, there are challenges in cell culture that require advanced process analytical technologies. Raman spectroscopy has proven to be advantageous for process monitoring and control, as demonstrated in this study using a perfusion process.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Engineering, Chemical

Monitoring of Oxygen, pH, CO2, and Biomass in Smart Single-Use Shake Flasks

Ruediger W. Maschke et al.

Summary: This article discusses the application of optical sensors in single-use shake flasks for measuring oxygen, carbon dioxide, pH, and biomass.

CHEMIE INGENIEUR TECHNIK (2022)

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Article Biotechnology & Applied Microbiology

Design and engineering characterization of a horizontal tubular bioreactor with spiral impeller for cell cultivation

Rajesh Sharma et al.

BIOCHEMICAL ENGINEERING JOURNAL (2022)

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Article Biotechnology & Applied Microbiology

Architectural and Technological Improvements to Integrated Bioprocess Models towards Real-Time Applications

Christopher Taylor et al.

Summary: Integrated process models can serve as the engine of a digital asset in a multistep-process digital twin, but face limitations in their deployment. This study improves integrated process models by introducing a simplified data model, increasing statistical robustness, adding a new simulation flow for scale-dependent variables, and describing a novel algorithm for data-driven environments. The proposed architectural and procedural requirements for a deployed digital twin provide a final framework for a digital asset in bioprocessing.

BIOENGINEERING-BASEL (2022)

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Article Biotechnology & Applied Microbiology

Feedback control of two supplemental feeds during fed-batch culture on a platform process using inline Raman models for glucose and phenylalanine concentration

Thaddaeus A. Webster et al.

Summary: Utilizing Raman models for glucose and phenylalanine concentrations to adjust feed rates in a fed-batch culture of a CHOK1SV GS-KO (R) cell line resulted in maintaining target concentrations and reducing feed additions compared to manual adjustments. This novel automation strategy also led to lower osmolality, more consistent nutrient environment, and higher harvest product concentration, demonstrating its potential for improved control in mammalian cell culture processes.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2021)

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Article Biotechnology & Applied Microbiology

Spectroscopy integration to miniature bioreactors and large scale production bioreactors-Increasing current capabilities and model transfer

Ruth C. Rowland-Jones et al.

Summary: The study evaluates a prototype that integrates spectroscopy into miniature bioreactor systems, demonstrating the potential value of applying spectroscopy at a small scale in the biopharmaceutical industry.

BIOTECHNOLOGY PROGRESS (2021)

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Article Biotechnology & Applied Microbiology

Tuning monoclonal antibody galactosylation using Ramanspectroscopy-controlledlactic acid feeding

Thomas W. Eyster et al.

Summary: The study developed a nutrient control strategy for CHO cell culture process based on Raman spectroscopy, achieving dual control of lactate and glucose levels. The third feeding strategy resulted in a significant reduction in ammonium levels (68%) while increasing mAb galactosylation levels by approximately 50%.

BIOTECHNOLOGY PROGRESS (2021)

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Review Chemistry, Analytical

Recent Advances in Electrochemical Biosensors: Applications, Challenges, and Future Scope

Anoop Singh et al.

Summary: Electrochemical biosensors are a class of sensors that convert biological information into current or voltage, with applications in medical, food industry, and other fields. Machine learning is essential for interpreting large sensing data and improving sensors' sensitivity.

BIOSENSORS-BASEL (2021)

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Review Biology

Bioprocess Control: Current Progress and Future Perspectives

Anurag S. Rathore et al.

Summary: Bioprocess control involves unique challenges such as non-linearity, variability, and complexity, requiring the use of modern control strategies. In addition to automation, control also includes aspects such as system architecture, software applications, hardware, and interfaces, all of which need to be optimized according to actual needs.

LIFE-BASEL (2021)

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Article Engineering, Environmental

CFD based mass transfer modeling of a single use bioreactor for production of monoclonal antibody biotherapeutics

Somesh Mishra et al.

Summary: Multiple models and methods were used in this study to simulate mAb production in a single use bioreactor, showing that bubble size distribution becomes more dispersed with increasing agitation speed. The predicted mass transfer coefficient values were within a small error range of the experimental data.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Biochemical Research Methods

Single in-line biomass probe detects CHO cell growth by capacitance and bacterial contamination by conductivity in bioreactor

Caitlin Morris et al.

Summary: Real-time monitoring of CHO cell growth using an inline conductivity/capacitance probe showed that abnormal increases in conductivity can be an indicator of bacterial contamination in bioreactors. Early detection of contamination using conductivity measurements can be beneficial for pharmaceutical liquid handling processes.

BIOTECHNOLOGY JOURNAL (2021)

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Article Engineering, Chemical

Mechanistic modelling of Chinese hamster ovary cell clarification using acoustic wave separator

Shantanu Banerjee et al.

Summary: Acoustic wave separation (AWS) is an effective method for continuous clarification of CHO cells, and a mechanistic model along with acoustic agglomeration kernel can predict cell size distribution. Experimental results show that flowrate and acoustic power are key factors affecting CSE, and the mechanistic model and Buckingham Pi theorem can accurately predict the CHO agglomeration process.

CHEMICAL ENGINEERING SCIENCE (2021)

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Article Computer Science, Interdisciplinary Applications

Synergising stoichiometric modelling with artificial neural networks to predict antibody glycosylation patterns in Chinese hamster ovary cells

Athanasios Antonakoudis et al.

Summary: In-process quality control of biotherapeutics requires computationally efficient process models. Existing kinetic cell culture models are effective but require considerable development effort. Integrating a stoichiometric model with an artificial neural network provides an accurate platform for product quality prediction.

COMPUTERS & CHEMICAL ENGINEERING (2021)

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Review Biochemical Research Methods

Practical monitoring technologies for cells and substrates in biomanufacturing

Kenneth F. Reardon

Summary: Precise control over bioreactor operation is crucial for optimal productivity and product quality, leading to an increased drive towards automation in biomanufacturing. Sensors are essential for monitoring parameters and substrate concentrations in order to achieve this automation in a wider array of bioreactors as the bioeconomy continues to grow.

CURRENT OPINION IN BIOTECHNOLOGY (2021)

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Review Biochemical Research Methods

Enabling development, manufacturing, and regulatory approval of biotherapeutics through advances in mass spectrometry

Izydor Apostol et al.

Summary: Mass spectrometers have become central to the development, characterization, and regulatory filings of biopharmaceuticals, with rapid technological advances improving their capabilities. These improvements have enabled their application across the entire drug development continuum and beyond, leading to a broader understanding of product quality and attribute-focused product development.

CURRENT OPINION IN BIOTECHNOLOGY (2021)

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Article Biochemical Research Methods

Towards a simple on-line coupling of ion exchange chromatography and native mass spectrometry for the detailed characterization of monoclonal antibodies

Amarande Murisier et al.

Summary: This study successfully demonstrated the direct hyphenation of cation exchange chromatography with a compact Time of Flight mass spectrometer for analyzing monoclonal antibodies. By testing various buffers and column dimensions, optimal chromatographic conditions were identified for rapid analysis of charge variants.

JOURNAL OF CHROMATOGRAPHY A (2021)

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Article Biotechnology & Applied Microbiology

Monitoring of heat- and light exposure of cell culture media by RAMAN spectroscopy: Towards an analytical tool for cell culture media quality control

Patrick Mayrhofer et al.

Summary: Cell culture media are complex solutions used for mammalian cells, crucial for protein expression quality and bioprocess performance. Chemometric analysis of RAMAN spectra can identify different media and track degradation conditions. RAMAN spectroscopy is a rapid, non-destructive method to distinguish media and find minor differences, suitable for quality control in bioprocessing.

BIOCHEMICAL ENGINEERING JOURNAL (2021)

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Article Biotechnology & Applied Microbiology

Development of a rapid polarized total synchronous fluorescence spectroscopy (pTSFS) method for protein quantification in a model bioreactor broth

Bernard O. Boateng et al.

Summary: This study developed a new method for protein quantification in bioreactor broth using polarized total synchronous fluorescence spectroscopy, which showed better analytical performance compared to traditional methods. By optimizing the process, faster online measurements and more accurate results were achieved.

BIOTECHNOLOGY AND BIOENGINEERING (2021)

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Article Biotechnology & Applied Microbiology

A genome-scale metabolic network model and machine learning predict amino acid concentrations in Chinese Hamster Ovary cell cultures

Song-Min Schinn et al.

Summary: Genome-scale metabolic models can accurately predict individual amino acid concentrations in culture medium throughout the production process by integrating machine learning, enabling real-time control of nutrient feeding.

BIOTECHNOLOGY AND BIOENGINEERING (2021)

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Article Engineering, Chemical

Reinforcement learning based optimization of process chromatography for continuous processing of biopharmaceuticals

Saxena Nikita et al.

Summary: This study introduces a novel approach based on reinforcement learning to separate charge variants in biopharmaceutical industry by optimizing flow rate, achieving good results in experimental validation. Compared to traditional trial and error methods, this approach shows higher efficiency in both optimization and computational aspects.

CHEMICAL ENGINEERING SCIENCE (2021)

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Article Computer Science, Interdisciplinary Applications

Data intelligence for process perf ormance prediction in biologics manufacturing

Nishanthi Gangadharan et al.

Summary: This study presents a tailored knowledge discovery integrative framework for handling historical bioprocess datasets, successfully predicting process performance at harvest from early time points. The proposed multi-model system utilizing machine learning can accurately predict performance at harvest after two weeks of operation using data generated as early as on the sixth day of the culture.

COMPUTERS & CHEMICAL ENGINEERING (2021)

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Article Engineering, Environmental

Performance prediction of ZVI-based anaerobic digestion reactor using machine learning algorithms

Weichao Xu et al.

Summary: The study evaluates three machine learning algorithms for predicting the performance of ZVI-based AD reactors and finds XGBoost to have the highest accuracy. Parameters like total solid of feedstock, sCOD, ZVI dosage, and particle size were identified as dominant factors affecting methane production. Deep learning outperformed XGBoost and random forest with the lowest root mean squared errors for predicting cumulative methane production.

WASTE MANAGEMENT (2021)

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Review Virology

Lentiviral Vector Bioprocessing

Christopher Perry et al.

Summary: This comprehensive review discusses the importance of individual bioprocess operations in lentiviral vector (LV) production, emphasizing the role of envelope proteins and bioprocessing on LVs. It explores considerations for optimization and scalability during production, as well as key steps such as purification and quantification of LVs.

VIRUSES-BASEL (2021)

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Article Engineering, Chemical

Process Analytical Technology for Precipitation Process Integration into Biologics Manufacturing towards Autonomous Operation-mAb Case Study

Lara Julia Lohmann et al.

Summary: The research demonstrated the feasibility of online measurement techniques such as Raman spectroscopy within the framework of process analytical technology. By combining DAD and Raman, higher process robustness and accuracy were achieved.

PROCESSES (2021)

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Article Biotechnology & Applied Microbiology

The application of Raman spectroscopy for monitoring product quality attributes in perfusion cell culture

Zimin Liu et al.

Summary: In-situ Raman spectroscopy can enhance real-time monitoring and control in cell culture processes, aligning with FDA guidelines and improving product quality control. By integrating real-time monitoring of product quality attributes, the system ensures stability and control of product quality during cell culture processes.

BIOCHEMICAL ENGINEERING JOURNAL (2021)

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Review Biotechnology & Applied Microbiology

A decade in review: use of data analytics within the biopharmaceutical sector

Matthew Banner et al.

Summary: This article evaluates the adoption of data analysis techniques within the biopharmaceutical sector, identifying the most dominant algorithms applied across different application areas and exploring any trends between data set size and algorithm adoption.

CURRENT OPINION IN CHEMICAL ENGINEERING (2021)

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Article Biotechnology & Applied Microbiology

Hybrid modeling-a key enabler towards realizing digital twins in biopharma?

Michael Sokolov et al.

Summary: Digital twins are an emerging technology in the manufacturing industry, aiming to achieve smart factories. In the biopharma sector, they have broad potential but face technological and organizational challenges. Hybrid modeling is seen as a key technology to realize the capabilities of digital twins in this environment.

CURRENT OPINION IN CHEMICAL ENGINEERING (2021)

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Article Biochemical Research Methods

Sequential Ion-Ion Reactions for Enhanced Gas-Phase Sequencing of Large Intact Proteins in a Tribrid Orbitrap Mass Spectrometer

Jake T. Kline et al.

Summary: Obtaining extensive sequencing of intact proteins is crucial for determining different proteoforms arising from the same gene. Advanced ion dissociation techniques, such as electron transfer dissociation and ultraviolet photodissociation, can improve sequencing results but have limitations for proteins >= 30 kDa. Proton transfer charge reduction (PTCR) combined with other ion activation techniques can enhance sequencing coverage for large proteins, addressing issues of signal overlap and low signal-to-noise fragments in mass spectrometry analysis.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)

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Article Engineering, Chemical

Digital Twin of mRNA-Based SARS-COVID-19 Vaccine Manufacturing towards Autonomous Operation for Improvements in Speed, Scale, Robustness, Flexibility and Real-Time Release Testing

Axel Schmidt et al.

Summary: The bottleneck in vaccine manufacturing capacity highlights the need for digital twins enabled by process analytical technology to improve efficiency and reduce failure rates. Additional technologies such as multisensory process analytical technology are proposed to further enhance manufacturing capabilities.

PROCESSES (2021)

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Article Biotechnology & Applied Microbiology

Online monitoring and control of upstream cell culture process using 1D and 2D-LC with SegFlow interface

Letha Chemmalil et al.

Summary: The biopharmaceutical industry is shifting towards continuous bioprocessing to reduce costs and improve efficiency, with the support of process analytical technologies (PAT). Knowledge-based operations can integrate product quality into processes to achieve desired critical quality attributes and reduce variability.

BIOTECHNOLOGY AND BIOENGINEERING (2021)

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Article Biotechnology & Applied Microbiology

Mechanistic and data-driven modeling of protein glycosylation

Coral Fung Shek et al.

Summary: Modulation of glycosylation is crucial in the development of therapeutic proteins, as different glycan moieties can significantly affect efficacy and safety. Computational tools, including mechanistic models and data-driven models, are used to understand and quantify the impact of glycosylation on therapeutic proteins. These tools help researchers gain insights into the glycosylation pathway and identify process levers for glycosylation.

CURRENT OPINION IN CHEMICAL ENGINEERING (2021)

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Article Biotechnology & Applied Microbiology

Bioprocess systems analysis, modeling, estimation, and control

Yu Luo et al.

Summary: The production of monoclonal antibody therapeutics is a rapidly growing multi-billion-dollar enterprise in the biopharmaceutical industry, but faces challenges in achieving consistent productivity and product quality. These challenges are now being addressed with process systems engineering techniques to achieve optimal bioprocess operations.

CURRENT OPINION IN CHEMICAL ENGINEERING (2021)

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Reprint Engineering, Manufacturing

Basic considerations for a digital twin of biointelligent systems: Applying technical design patterns to biological systems (Reprinted from CIRP Journal of Manufacturing Science and Technology, vol 31, pg 548-560, 2020)

R. Miehe et al.

Summary: This paper discusses the basic considerations of applying the asset administration shell and the RAMI4.0 architecture to biological subsystems, aiming to ensure the interoperability of biointelligent manufacturing systems. The paper seeks to initiate a scientific discourse across disciplinary boundaries.

CIRP JOURNAL OF MANUFACTURING SCIENCE AND TECHNOLOGY (2021)

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Review Automation & Control Systems

Reinforcement learning for batch process control: Review and perspectives

Haeun Yoo et al.

Summary: Batch or semi-batch processing in industrial chemical manufacturing is facing challenges in control technology. Reinforcement learning offers a potential alternative with significant improvements. This paper discusses the advantages of reinforcement learning over traditional control methods and its applications in industrial chemical process control.

ANNUAL REVIEWS IN CONTROL (2021)

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Review Computer Science, Artificial Intelligence

Literature review of Industry 4.0 and related technologies

Ercan Oztemel et al.

JOURNAL OF INTELLIGENT MANUFACTURING (2020)

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Article Biotechnology & Applied Microbiology

Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors

S. Metze et al.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2020)

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Article Biochemical Research Methods

Neural network-based fingerprinting of monoclonal antibody aggregation using biolayer interferometry

Niharika Budholiya et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

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Article Biotechnology & Applied Microbiology

Applications of off-gas mass spectrometry in fed-batch mammalian cell culture

Hai-Yuan Goh et al.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2020)

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Article Biotechnology & Applied Microbiology

Automatic real-time calibration, assessment, and maintenance of generic Raman models for online monitoring of cell culture processes

Aditya Tulsyan et al.

BIOTECHNOLOGY AND BIOENGINEERING (2020)

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Article Biotechnology & Applied Microbiology

Raman spectroscopy as a method to replace off-line pH during mammalian cell culture processes

Carl Rafferty et al.

BIOTECHNOLOGY AND BIOENGINEERING (2020)

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Article Biochemical Research Methods

Multivariate Data Analysis Methodology to Solve Data Challenges Related to Scale-Up Model Validation and Missing Data on a Micro-Bioreactor System

Stephen Goldrick et al.

BIOTECHNOLOGY JOURNAL (2020)

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Article Automation & Control Systems

Linearized min-max robust model predictive control: Application to the control of a bioprocess

S. E. Benattia et al.

INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL (2020)

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Article Biotechnology & Applied Microbiology

A novel method based on nonparametric regression with a Gaussian kernel algorithm identifies the critical components in CHO media and feed optimization

Mao Zou et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2020)

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Article Biochemical Research Methods

Online monitoring of the cell-specific oxygen uptake rate with an in situ combi-sensor

Katharina Dahlmann et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

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Article Biochemical Research Methods

Current and future requirements to industrial analytical infrastructure-part 2: smart sensors

Tobias Eifert et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

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Article Biochemical Research Methods

Comparison of Modeling Methods for DoE-Based Holistic Upstream Process Characterization

Benjamin Bayer et al.

BIOTECHNOLOGY JOURNAL (2020)

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Article Biotechnology & Applied Microbiology

Analysis of chemometric models applied to Raman spectroscopy for monitoring key metabolites of cell culture

Carl Rafferty et al.

BIOTECHNOLOGY PROGRESS (2020)

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Article Computer Science, Interdisciplinary Applications

Reinforcement learning for batch bioprocess optimization

P. Petsagkourakis et al.

COMPUTERS & CHEMICAL ENGINEERING (2020)

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Review Biotechnology & Applied Microbiology

Kinetic modeling of Chinese hamster ovary cell culture: factors and principles

Peifeng Tang et al.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators

Baowei Wang et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Raman spectroscopic based chemometric models to support a dynamic capacitance based cell culture feeding strategy

Carl Rafferty et al.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2020)

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Article Biotechnology & Applied Microbiology

Hybrid-EKF: Hybrid model coupled with extended Kalman filter for real-time monitoring and control of mammalian cell culture

Harini Narayanan et al.

BIOTECHNOLOGY AND BIOENGINEERING (2020)

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Article Biotechnology & Applied Microbiology

Cell culture process metabolomics together with multivariate data analysis tools opens new routes for bioprocess development and glycosylation prediction

Philipp Zurcher et al.

BIOTECHNOLOGY PROGRESS (2020)

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Article Chemistry, Analytical

Electrochemical Dissolved Oxygen Sensor-Integrated Platform for Wireless In Situ Bioprocess Monitoring

Justin M. Stine et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Biotechnology & Applied Microbiology

Kinetic Modeling and Numerical Simulation as Tools to Scale Microalgae Cell Membrane Permeabilization by Means of Pulsed Electric Fields (PEF) From Lab to Pilot Plants

Justus Knappert et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Technology outlook for real-time quality attribute and process parameter monitoring in biopharmaceutical development-A review

Dhanuka P. Wasalathanthri et al.

BIOTECHNOLOGY AND BIOENGINEERING (2020)

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Review Biotechnology & Applied Microbiology

Toward in silico CMC: An industrial collaborative approach to model-based process development

David Roush et al.

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Validation of an optical sensor-based high-throughput bioreactor system for mammalian cell culture

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