期刊
BIOTECHNOLOGY ADVANCES
卷 67, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2023.108206
关键词
Glycosylation; Glycoengineering; Biologic; Therapeutic protein; Gene therapy; Cell-based therapy; Monoclonal antibody
Glycosylation, a critical quality attribute, significantly influences the physical properties, safety profile, and biological activity of therapeutic proteins. Optimizing protein glycosylation is important for developing more effective therapies.
Over recent decades, therapeutic proteins have had widespread success in treating a myriad of diseases. Glycosylation, a near universal feature of this class of drugs, is a critical quality attribute that significantly influences the physical properties, safety profile and biological activity of therapeutic proteins. Optimizing protein glycosylation, therefore, offers an important avenue to developing more efficacious therapies. In this review, we discuss specific examples of how variations in glycan structure and glycoengineering impacts the stability, safety, and clinical efficacy of protein-based drugs that are already in the market as well as those that are still in preclinical development. We also highlight the impact of glycosylation on next generation biologics such as T cellbased cancer therapy and gene therapy.
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