Overview of nanozymes with phosphatase-like activity

Nanomaterials with intrinsic enzyme activity, referred to as nanozymes, have attracted substantial attention in recent years. Among them, phosphatase-mimicking nanozymes have become an increasingly important focus for future research, considering that phosphatase is not only one of key enzymes for phosphorous metabolism, which is essential for many biological processes (e.g., cellular regulation and signaling), but also one of extensively used biocatalytic labels in the enzyme-linked assays as well as a powerful tool enzyme in molecular biology labora-tories. Nevertheless, compared with extensive oxidoreductase-mimicking nanozymes, there are a very limited number of nanozymes with phosphatase-like activity have been explored at present. The increasing demand of complex and individualized phosphatase-involved catalytic behaviors is pushing the development of more advanced phosphatase-mimicking nanozymes. Thus, we present an overview on recently reported phosphatase-like nanozymes, providing guidelines and new insights for designing more advanced phosphatase-mimicking nanozyme with superior properties.

Automated summary

Nanomaterials with intrinsic enzyme activity, known as nanozymes, have gained considerable attention in recent years. Among them, phosphatase-mimicking nanozymes have become increasingly important for future research. However, the number of nanozymes with phosphatase-like activity is limited compared to extensively studied oxidoreductase-mimicking nanozymes. The increasing demand for complex and individualized phosphatase-involved catalytic behaviors is driving the development of more advanced phosphatase-mimicking nanozymes. This overview provides guidelines and insights for designing superior phosphatase-mimicking nanozymes.