Electrochemical DNAzyme-based biosensors for disease diagnosis

DNAzyme-based electrochemical biosensors provide exceptional analytical sensitivity and high target recognition specificity for disease diagnosis. This review provides a critical perspective on the fundamental and applied impact of incorporating DNAzymes in the field of electrochemical biosensing. Specifically, we highlight recent advances in creating DNAzyme-based electrochemical biosensors for diagnosing infectious diseases, cancer and regulatory diseases. We also develop an understanding of challenges around translating the research in the field of DNAzyme-based electrochemical biosensors from labs to clinics, followed by a discussion on different strategies that can be applied to enhance the performance of the currently existing technologies to create truly pointof-care electrochemical DNAzyme biosensors.

Automated summary

DNAzyme-based electrochemical biosensors exhibit excellent sensitivity and specificity for disease diagnosis. This review critically discusses the impact of incorporating DNAzymes in electrochemical biosensing, focusing on the recent advances in developing DNAzyme-based electrochemical biosensors for infectious diseases, cancer, and regulatory diseases. It also addresses the challenges in translating these technologies from labs to clinics and discusses strategies to enhance the performance of existing technologies to create point-of-care electrochemical DNAzyme biosensors.