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Microneedle arrays integrated with microfluidic systems: Emerging applications and fluid flow modeling

BIOMICROFLUIDICS (2023)

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Summary: Organ-on-a-chip (OOC) platforms provide a more realistic environment compared to animal models and conventional cell cultures, offering continuous perfusion of cell cultures, integration of biosensors, and 3D structures fabricated through bioprinting. These platforms have great potential for understanding organ functions, studying disease impacts, and drug screening. This review presents an overview of bioprinting techniques, their advantages and limitations, recent advancements, applications, and future prospects of the 3D-bioprinted OOC platforms, as well as current challenges and future directions.

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Review Chemistry, Multidisciplinary

Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration

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Summary: Microneedles have been extensively studied for transdermal delivery and sampling, but many patches fail to fully penetrate the skin surface. It is crucial to consider skin mechanics for improving microneedle design and insertion practice, enhancing penetration efficiency.

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Kai Takeuchi et al.

Summary: The study developed a fluidic system that directly interfaces porous microneedles with a microfluidic chip for continuous sampling of ISF. Porous and flexible microneedles made of PDMS are connected to the microfluidic chip, showing continuous flow of phosphate buffered saline (PBS). This integrated device offers minimally invasive and continuous biosampling for long-term healthcare monitoring.

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3D-Printed Microneedles for Point-of-Care Biosensing Applications

Misagh Rezapour Sarabi et al.

Summary: Microneedles are a promising technology for painless and minimally invasive injections, offering lower tissue damage. By combining biosensors and samples collected with microneedles, portable biosensing applications can be enabled.

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The Finite Element Analysis Research on Microneedle Design Strategy and Transdermal Drug Delivery System

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Machine Learning-Enabled Prediction of 3D-Printed Microneedle Features

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ISCIENCE (2022)

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Microfluidic Invasion Chemotaxis Platform for 3D Neurovascular Co-Culture

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Summary: Advances in microfabrication and biomaterials have led to the development of microfluidic chips for studying tissue and organ models. In this study, a fabrication protocol for GelMA hydrogel inside a microfluidic chip was proposed, and its chemical composition, surface morphology, structural properties, and cell localization were analyzed. The results showed that GelMA displayed stable structure and the ability to mimic the natural cell environment, making it suitable for tissue engineering applications and 3D cell culture studies.

FLUIDS (2022)

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Bingbing Gao et al.

Summary: The i-SMD is an intelligent dressing with drug release and biochemical analysis capabilities, showing promise in facilitating wound healing.

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Microneedle system: a modulated approach for penetration enhancement

Nirupma Khare et al.

Summary: Microneedles combined with penetration enhancement techniques can improve drug permeation through the skin by enhancing skin penetration through physical and chemical methods, while reducing pain. The combination of microneedles with these techniques can significantly increase the speed and efficiency of drug permeation through the skin.

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Mikail Temirel et al.

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Characterization method for calculating diffusion coefficient of drug from polylactic acid (PLA) microneedles into the skin

Libo Wu et al.

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Microneedle for transdermal drug delivery: current trends and fabrication

Jae Hwan Jung et al.

Summary: Transdermal drug delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. Microneedles are a painless, less invasive, and easy to self-administer transdermal drug delivery system with high drug bioavailability. With advancements in formulation technologies, the drug-loading capability of microneedles can be improved.

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