Maresin1 can be a potential therapeutic target for nerve injury

Nerve injury significantly affects human motor and sensory function due to destruction of the integrity of nerve structure. In the wake of nerve injury, glial cells are activated, and synaptic integrity is destroyed, causing inflammation and pain hypersensitivity. Maresin1, an omega-3 fatty acid, is a derivative of docosahexaenoic acid. It has showed beneficial effects in several animal models of central and peripheral nerve injuries. In this review, we summarize the anti-inflammatory, neuroprotective and pain hypersensitivity effects of maresin1 in nerve injury and provide a theoretical basis for the clinical treatment of nerve injury using maresin1.

Automated summary

Nerve injury has detrimental effects on human motor and sensory function, disrupting nerve structure integrity. Activation of glial cells and disruption of synaptic integrity lead to inflammation and pain hypersensitivity. Maresin1, an omega-3 fatty acid derivative, has shown beneficial effects in various animal models of nerve injury. This review summarizes the anti-inflammatory, neuroprotective, and pain hypersensitivity effects of maresin1 and provides the theoretical basis for its clinical application in treating nerve injury.